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View article: Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases
Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases Open
View article: Low LDL-Cholesterol and Hemorrhagic Risk: Mechanistic Insights and Clinical Perspectives
Low LDL-Cholesterol and Hemorrhagic Risk: Mechanistic Insights and Clinical Perspectives Open
Low-density lipoprotein cholesterol (LDL-C) plays a central role in lipid metabolism and is a well-established therapeutic target for the prevention of atherosclerotic cardiovascular diseases (CVDs). In recent years, increasingly aggressiv…
View article: DNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation
DNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation Open
For the first time, we showed that DNA methylation changes are associated with regulation of MED complex subunits in early diagnosis of AF patients. Clinically, MED1 and MED23 hypermethylation showed a diagnostic value not inferior to circ…
View article: Acute kidney failure due to varicella-zoster virus solved by early antiviral treatment based on brivudin
Acute kidney failure due to varicella-zoster virus solved by early antiviral treatment based on brivudin Open
A relation between acute kidney failure (AKF) and recent infection is well known in the medical community. Recent viral infections are rarer than bacterial infections in adults and patients. Here, we report a case of a 65-year-old woman wh…
View article: Predicting exercise intolerance in elderly individuals with heart failure using the 30-second chair stand test
Predicting exercise intolerance in elderly individuals with heart failure using the 30-second chair stand test Open
View article: Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification
Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification Open
Familial dilated cardiomyopathy (DCM) is among the leading indications for heart transplantation. DCM alters the transcriptomic profile. The alteration or activation/silencing of physiologically operating transcripts may explain the onset …
View article: Alternative splicing in cardiomyopathy insights
Alternative splicing in cardiomyopathy insights Open
View article: Mediator complex in neurological disease
Mediator complex in neurological disease Open
Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator compl…
View article: Basic Pathogenic Mechanisms and Epigenetic Players Promoted by Extracellular Vesicles in Vascular Damage
Basic Pathogenic Mechanisms and Epigenetic Players Promoted by Extracellular Vesicles in Vascular Damage Open
Both progression from the early pathogenic events to clinically manifest cardiovascular diseases (CVD) and cancer impact the integrity of the vascular system. Pathological vascular modifications are affected by interplay between endothelia…
View article: Supplementary Figure 1 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Supplementary Figure 1 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis Open
Supplementary Figure 1 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
View article: Data from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Data from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis Open
We know that the Yin Yang 1 protein (YY1) overexpression is positively and strongly correlated with the degree of malignancy of bone tumors. Therefore, we questioned whether we could influence cell invasiveness by deleting YY1 in human ost…
View article: Data from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Data from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis Open
We know that the Yin Yang 1 protein (YY1) overexpression is positively and strongly correlated with the degree of malignancy of bone tumors. Therefore, we questioned whether we could influence cell invasiveness by deleting YY1 in human ost…
View article: Supplementary Tables 1-2 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Supplementary Tables 1-2 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis Open
Supplementary Tables 1-2 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
View article: Supplementary Figure 1 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Supplementary Figure 1 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis Open
Supplementary Figure 1 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
View article: Supplementary Tables 1-2 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Supplementary Tables 1-2 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis Open
Supplementary Tables 1-2 from Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
View article: Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension
Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension Open
Pathogenic DNA methylation changes may be involved in pulmonary arterial hypertension (PAH) onset and its progression, but there is no data on potential associations with patient-derived hemodynamic parameters. The reduced representation b…
View article: MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia
MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia Open
Central post-stroke pain (CPSP) and associated depression remain poorly understood and pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested to be involved in CPSP pathophysiology. The goal of this stu…
View article: Machine Learning and Bioinformatics Framework Integration to Potential Familial DCM-Related Markers Discovery
Machine Learning and Bioinformatics Framework Integration to Potential Familial DCM-Related Markers Discovery Open
Objectives: Dilated cardiomyopathy (DCM) is characterized by a specific transcriptome. Since the DCM molecular network is largely unknown, the aim was to identify specific disease-related molecular targets combining an original machine lea…
View article: Circulating CD4+T/methylation signatures of network-oriented SOCS3, ITGAL, NFIC, NCOR2, PGK1 genes associate with hemodynamics in pulmonary arterial hypertension patients
Circulating CD4+T/methylation signatures of network-oriented SOCS3, ITGAL, NFIC, NCOR2, PGK1 genes associate with hemodynamics in pulmonary arterial hypertension patients Open
Background CD4+ T cells are associated with pulmonary arterial hypertension (PAH) pathogenesis but mechanistic insights are limited. Purpose To identify differential CD4+ T methylation signatures in healthy controls vs PAH and evaluate a p…
View article: <i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis
<i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis Open
Acute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease.We performed an epigenome-wide analysis of circulating CD4+ and CD8+ T cells isolated from ACS patients and healthy sub…
View article: Soft drinks and sweeteners intake: Possible contribution to the development of metabolic syndrome and cardiovascular diseases. Beneficial or detrimental action of alternative sweeteners?
Soft drinks and sweeteners intake: Possible contribution to the development of metabolic syndrome and cardiovascular diseases. Beneficial or detrimental action of alternative sweeteners? Open
View article: The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia
The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia Open
View article: <i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis
<i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis Open
Acute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease. We performed an epigenome-wide analysis of circulating CD4+ and CD8+ T cells isolated from ACS patients and healthy su…
View article: Supplementary Material for: DNA Methylation Profile of the <b><i>SREBF2</i></b> Gene in Human Fetal Aortas
Supplementary Material for: DNA Methylation Profile of the <b><i>SREBF2</i></b> Gene in Human Fetal Aortas Open
Increasing evidence suggests that maternal cholesterol represents an important risk factor for atherosclerotic disease in offspring already during pregnancy, although the underlying mechanisms have not yet been elucidated. Eighteen human f…
View article: Integrated analysis of DNA methylation profile in HLA-G gene and imaging in coronary heart disease
Integrated analysis of DNA methylation profile in HLA-G gene and imaging in coronary heart disease Open
Aims Immune endothelial inflammation, underlie coronary heart disease (CHD) related phenotypes, could provide new insight into the pathobiology of the disease. We investigated DNA methylation level of the unique CpG island of HLA-G gene in…
View article: DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in increasing hyperglycemia: PIRAMIDE pilot study
DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in increasing hyperglycemia: PIRAMIDE pilot study Open
SPARC hypomethylation in CD08+ T cells may be a useful biomarker of vascular complications in Pre-Diab with a possible role for primary prevention warranting further multicenter clinical trials to validate our findings.
View article: Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study
Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study Open
Reduced levels of circulating HLA-G molecules could derive from epigenetic marks. Epigenetics phenomena induce hypomethylation of specific regions into 5'UTR-CpG island of HLA-G gene in CHD patients with obstructive non critical stenosis v…
View article: Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells
Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells Open
Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the reg…
View article: Early targeted DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in different stages of impaired glucose homeostasis Cardiovascular Diabetology
Early targeted DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in different stages of impaired glucose homeostasis Cardiovascular Diabetology Open
Background: Despite current intensive treatments, hyperglycemic patients have an unfavorable prognosis due to severe CHD and development of complications. The interplay between hyperglycemia and systemic inflammation can modify patterns of…
View article: Strengths and Opportunities of Network Medicine in Cardiovascular Diseases
Strengths and Opportunities of Network Medicine in Cardiovascular Diseases Open
Network medicine can advance current medical practice by arising as response to the limitations of a reductionist approach focusing on cardiovascular (CV) diseases as a direct consequence of a single defect. This molecular-bioinformatic ap…