Conelius Ngwa
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View article: Retraction notice to “Brain endothelial CD200 signaling protects brain against ischemic damage” [Brain Res. Bull. 207 (2024) 110864]
Retraction notice to “Brain endothelial CD200 signaling protects brain against ischemic damage” [Brain Res. Bull. 207 (2024) 110864] Open
View article: Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling
Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling Open
View article: Escape of Kdm6a from X chromosome is detrimental to ischemic brains via IRF5 signaling
Escape of Kdm6a from X chromosome is detrimental to ischemic brains via IRF5 signaling Open
The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our prior research has su…
View article: RETRACTED: Brain endothelial CD200 signaling protects brain against ischemic damage
RETRACTED: Brain endothelial CD200 signaling protects brain against ischemic damage Open
View article: Central IRF4/5 Signaling Are Critical for Microglial Activation and Impact on Stroke Outcomes
Central IRF4/5 Signaling Are Critical for Microglial Activation and Impact on Stroke Outcomes Open
View article: Regulation of microglial activation in stroke in aged mice: a translational study
Regulation of microglial activation in stroke in aged mice: a translational study Open
Numerous neurochemical changes occur with aging and stroke mainly affects the elderly. Our previous study has found interferon regulatory factor 5 (IRF5) and 4 (IRF4) regulate neuroinflammation in young stroke mice. However, whether the IR…
View article: X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals
X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals Open
View article: X, but not Y, chromosomal complement contributes to stroke sensitivity in aged animals
X, but not Y, chromosomal complement contributes to stroke sensitivity in aged animals Open
Post-menopausal women become vulnerable to stroke and have poorer outcomes and higher mortality than age-matched men and previous studies suggested that sex chromosomes play a vital role in mediating stroke sensitivity in the aged. It is u…
View article: Sex differences in the immune response to acute COVID-19 respiratory tract infection
Sex differences in the immune response to acute COVID-19 respiratory tract infection Open
View article: Age and sex differences in primary microglia culture: A comparative study
Age and sex differences in primary microglia culture: A comparative study Open
View article: Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke
Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke Open
Background and Purpose: CD200 (cluster of differentiation 200), a highly glycosylated protein primarily expressed on neurons in the central nervous system, binds with its receptor CD200R to form an endogenous inhibitory signal against immu…
View article: Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization
Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization Open
The G-quadruplex (G4-DNA or G4) is a secondary DNA structure formed by DNA sequences containing multiple runs of guanines. While it is now firmly established that stabilized G4s lead to enhanced genomic instability in cancer cells, whether…
View article: X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals
X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals Open
View article: Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia
Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia Open
Background: Interferon Regulatory Factor (IRF) 5 and 4 play a determinant role in regulating microglial pro- and anti-inflammatory responses to cerebral ischemia. How microglial IRF5 and IRF4 signaling are activated has been elusive. We hy…
View article: Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes
Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes Open
Significance Cerebral ischemia is a powerful stimulus to induce pro- and antiinflammatory responses, with the former destructive and the latter reparative in the disease progress. Microglia, the resident immune cells in the brain, are the …
View article: CD200-CD200R signaling and diseases: a potential therapeutic target?
CD200-CD200R signaling and diseases: a potential therapeutic target? Open
CD200 and its receptor, CD200R, constitutes an endogenous inhibitory signaling, and is being increasingly recognized in studies of various central nervous system (CNS) disorders. Emerging data have demonstrated that neuronal CD200 binds to…
View article: A Hyperfluorinated Hydrophilic Molecule for Aqueous <sup>19</sup>F MRI Contrast Media
A Hyperfluorinated Hydrophilic Molecule for Aqueous <sup>19</sup>F MRI Contrast Media Open
Fluorine-19 ( 19 F) magnetic resonance imaging (MRI) has the potential for a wide range of in vivo applications but is limited by lack of flexibility in exogenous probe formulation. Most 19 F MRI probes are composed of perfluorocarbons (PF…