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View article: Orphan broadly RBD-binding antibodies annotate three remaining conserved RBD epitopes along SARS-CoV-2 evolution
Orphan broadly RBD-binding antibodies annotate three remaining conserved RBD epitopes along SARS-CoV-2 evolution Open
The receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein continues to evolve, facilitating antibody evasion. It remains unclear whether any conserved RBD epitopes persist across SARS-CoV-2 variants and whether vaccination and/…
View article: Progressive Retinal Vascular and Neuronal Degeneration in BXD32 Mice: A Model for Age-Dependent Neurovascular Pathology
Progressive Retinal Vascular and Neuronal Degeneration in BXD32 Mice: A Model for Age-Dependent Neurovascular Pathology Open
Retinal vasculature is essential for maintaining visual function by supporting metabolically active neurons. However, the retina lacks redundant blood supply, rendering it highly susceptible to vascular dysfunction. Understanding mechanism…
View article: MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors
MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors Open
Unlike preceding MERS-related coronaviruses, the recently identified MjHKU4r-CoV-1 strain can directly infect human cells. Nonetheless, its potential pathogenic attributes and underlying molecular mechanisms remain unclear. We find that Mj…
View article: Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts
Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts Open
Objectives: Understanding the antibody response in monkeypox virus (MPXV)-infected and uninfected individuals is essential for developing next-generation MPXV vaccines. This study aimed to characterize neutralizing antibody (NAb) and antib…
View article: Structure-guided bispecific antibody engineering confers broad protection against KP.3.1.1 and sarbecoviruses
Structure-guided bispecific antibody engineering confers broad protection against KP.3.1.1 and sarbecoviruses Open
The emergence of SARS-CoV-2 variants like KP.2 and KP.3.1.1 challenges COVID-19 countermeasures. Bispecific antibodies (bsAbs) targeting two antigens show promise, but the impact of scFv sequence arrangement on functionality remains unclea…
View article: Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza
Ferritin-Based HA DNA Vaccine Outperforms Conventional Designs in Inducing Protective Immunity Against Seasonal Influenza Open
Background: Influenza remains a persistent public health challenge due to antigenic drift and shift, necessitating vaccines capable of eliciting broad and durable immunity. Hemagglutinin (HA) antigen serves as the critical target for elici…
View article: Artificial Intelligence in Orthopedic Surgery: Current Applications, Challenges, and Future Directions
Artificial Intelligence in Orthopedic Surgery: Current Applications, Challenges, and Future Directions Open
Artificial intelligence (AI) drives transformative changes in orthopedic surgery, steering it toward precision and personalization through intelligent applications in preoperative planning, intraoperative assistance, and postoperative reha…
View article: The relationship between pregnancy stress and antepartum depression in Chinese pregnant women: the mediating effect of social support and maternal health literacy
The relationship between pregnancy stress and antepartum depression in Chinese pregnant women: the mediating effect of social support and maternal health literacy Open
Objective This study aims to explore the relationship between pregnancy stress (PS) and antenatal depression (AD) among Chinese pregnant women and to investigate whether maternal health literacy (MHL) and social support (SS) mediate the re…
View article: Education Management For Inclusive Arts Curriculum In Schools
Education Management For Inclusive Arts Curriculum In Schools Open
An inclusion of an arts curriculum in the schools is a great step toward an equitable and holistic education. The purpose of this paper is to explore the role that education management plays in designing, implementation and evaluation of a…
View article: Gamification In Arts Education: A Modern Teaching Strategy
Gamification In Arts Education: A Modern Teaching Strategy Open
In various other fields including education, gamification, the use of game elements in the non-game context, has become more and more popular. Gamification has proven to be a novel and engaging way of teaching and learning in the field of …
View article: Public-Private Partnerships In Education: A Management Perspective On Achieving SDG Targets
Public-Private Partnerships In Education: A Management Perspective On Achieving SDG Targets Open
Public-Private Partnerships (PPPs) function as vital mechanisms which drive achievement of global development goals especially in educational contexts. PPPs represent a potential framework for SDG 4 which aims to provide all people with in…
View article: The Evolution Of Management Themes In Contemporary Visual Arts
The Evolution Of Management Themes In Contemporary Visual Arts Open
The connection between art management and contemporary visual arts becomes more vital because art world directives change according to modern economic and cultural standards. This report details the transformation of management concepts in…
View article: The Role Of Arts In Enhancing Critical Thinking In Education
The Role Of Arts In Enhancing Critical Thinking In Education Open
The role that arts play in education is of much more than creative expression and aesthetic development. Cognitive skills and, increasingly, arts studies stress the importance of arts in enhancing thinking, including critical thinking skil…
View article: Immunocytochemical Profiling of CD4+, CD8+, and CD3+ T Cell Subsets: Clinical Implications in Rheumatic Diseases, Respiratory Disorders, and Oncology
Immunocytochemical Profiling of CD4+, CD8+, and CD3+ T Cell Subsets: Clinical Implications in Rheumatic Diseases, Respiratory Disorders, and Oncology Open
Immunocytochemical staining has emerged as a cost-effective and minimally invasive method for profiling T cell subsets (CD4+, CD8+, and CD3+) in the clinical setting. The quantification of T lymphocyte subsets has become a critical tool fo…
View article: Herpesvirus-associated diseases: biomarkers and advancements in clinical research
Herpesvirus-associated diseases: biomarkers and advancements in clinical research Open
Herpesviruses are responsible for a broad spectrum of diseases that impact various tissues and organs, which could lead to complex pathological manifestations and severe complications. These infections represent a significant burden on glo…
View article: Educational Leadership And Its Influence On Art-Based Learning
Educational Leadership And Its Influence On Art-Based Learning Open
This paper analyzes the art-based learning with an educational leadership in primary and secondary educational institutions. This study seeks into the ways in which leadership decisions in art-based teaching and learning can be fostered to…
View article: Prediction of induction chemotherapy efficacy in patients with locally advanced nasopharyngeal carcinoma using habitat subregions derived from multi-modal MRI radiomics
Prediction of induction chemotherapy efficacy in patients with locally advanced nasopharyngeal carcinoma using habitat subregions derived from multi-modal MRI radiomics Open
Objective This study aims to predict the early efficacy of induction chemotherapy (ICT) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) through habitat subregion analysis and multimodal MRI radiomics techniques. Methods…
View article: Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs
Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs Open
The dynamics of lifespan are shaped by DNA variants that exert effects at different ages. We have mapped genetic loci that modulate age-specific mortality using an actuarial approach. We started with an initial population of 6,438 pubescen…
View article: Anti-S2 antibodies responsible for the SARS-CoV-2 infection-induced serological cross-reactivity against MERS-CoV and MERS-related coronaviruses
Anti-S2 antibodies responsible for the SARS-CoV-2 infection-induced serological cross-reactivity against MERS-CoV and MERS-related coronaviruses Open
Sarbecoviruses, such as SARS-CoV-2, utilize angiotensin-converting enzyme 2 (ACE2) as the entry receptor; while merbecoviruses, such as MERS-CoV, use dipeptidyl peptidase 4 (DPP4) for viral entry. Recently, several MERS-related coronavirus…
View article: Independent Mobility GPT (IDM-GPT): A Self-Supervised Multi-Agent Large Language Model Framework for Customized Traffic Mobility Analysis Using Machine Learning Models
Independent Mobility GPT (IDM-GPT): A Self-Supervised Multi-Agent Large Language Model Framework for Customized Traffic Mobility Analysis Using Machine Learning Models Open
With the urbanization process, an increasing number of sensors are being deployed in transportation systems, leading to an explosion of big data. To harness the power of this vast transportation data, various machine learning (ML) and arti…
View article: Paediatric varicella epidemiology in urban Beijing, China, 2014–2023
Paediatric varicella epidemiology in urban Beijing, China, 2014–2023 Open
Data on the clinical epidemiology of varicella in Beijing, China, remain limited. Here, we present an analysis of paediatric varicella cases from 2014 to 2023, including 10,049 cases from two children's hospitals. A gradual decline in the …
View article: ADEPT: A Noninvasive Method for Determining Elastic Parameters of Valve Tissue.
ADEPT: A Noninvasive Method for Determining Elastic Parameters of Valve Tissue. Open
Computer simulation of "virtual interventions" may inform optimal valve repair for a given patient prior to intervention. However, the paucity of noninvasive methods to determine in vivo mechanical parameters of valves limits the accuracy …
View article: MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma
MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma Open
Cholesterol metabolism is abnormally active in tumour cells. Metabolic enzymes related to cholesterol metabolism are upregulated in tumours, but their nonmetabolic functions remain unclear. We found that MVK (mevalonate kinase) is upregula…