Mincong Huang
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View article: Isolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitis
Isolinderalactone regulates macrophage polarization and efferocytosis by activating the LXRα pathway against ulcerative colitis Open
Background Ulcerative colitis (UC), a chronic inflammatory bowel disease, remains an unmet medical need. Lindera aggregata, a traditional Chinese medicine used in treating gastrointestinal disorders, has demonstrated anti-UC efficacy, thou…
View article: Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages
Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases the incidence of colorectal cancer (CRC). In the pathophysiology of IBD, ubiquitination/deubiquitination plays a critical re…
View article: First Activations Matter: Training-Free Methods for Dynamic Activation in Large Language Models
First Activations Matter: Training-Free Methods for Dynamic Activation in Large Language Models Open
Dynamic activation (DA) techniques, such as DejaVu and MoEfication, have demonstrated their potential to significantly enhance the inference efficiency of large language models (LLMs). However, these techniques often rely on ReLU activatio…
View article: Linderanine C regulates macrophage polarization by inhibiting the MAPK signaling pathway against ulcerative colitis
Linderanine C regulates macrophage polarization by inhibiting the MAPK signaling pathway against ulcerative colitis Open
Ulcerative colitis (UC) is a chronic non-specific inflammatory disease involving the mucosa and submucosa of the rectum and colon. Lindera aggregate (Sims) Kosterm is a traditional Chinese herb used for thousands of years in the treatment …
View article: QQQ: Quality Quattuor-Bit Quantization for Large Language Models
QQQ: Quality Quattuor-Bit Quantization for Large Language Models Open
Quantization is a proven effective method for compressing large language models. Although popular techniques like W8A8 and W4A16 effectively maintain model performance, they often fail to concurrently speed up the prefill and decoding stag…
View article: Re-evaluating the Memory-balanced Pipeline Parallelism: BPipe
Re-evaluating the Memory-balanced Pipeline Parallelism: BPipe Open
Pipeline parallelism is an essential technique in the training of large-scale Transformer models. However, it suffers from imbalanced memory consumption, leading to insufficient memory utilization. The BPipe technique was proposed to addre…
View article: Peach gum polysaccharides promotes epithelial proliferation to attenuate ulcerative colitis by PI3K/AKT pathway
Peach gum polysaccharides promotes epithelial proliferation to attenuate ulcerative colitis by PI3K/AKT pathway Open
Peach gum is a homologous substance of medicine and food, mainly composed of polysaccharides. This study aimed to investigate the effectiveness of Peach gum polysaccharides (PGP) in treatment of ulcerative colitis (UC) and explore its mech…
View article: Panoptic Reconstruction of Immersive Virtual Soundscapes Using Human-Scale Panoramic Imagery with Visual Recognition
Panoptic Reconstruction of Immersive Virtual Soundscapes Using Human-Scale Panoramic Imagery with Visual Recognition Open
This work, situated at Rensselaer’s Collaborative-Research Augmented Immersive Virtual Environment Laboratory (CRAIVE-Lab), uses panoramic image datasets for spatial audio display. A system is developed for the room-centered immersive virt…
View article: Root Extract of Lindera aggregata (Sims) Kosterm. Modulates the Th17/Treg Balance to Attenuate DSS-Induced Colitis in Mice by IL-6/STAT3 Signaling Pathway
Root Extract of Lindera aggregata (Sims) Kosterm. Modulates the Th17/Treg Balance to Attenuate DSS-Induced Colitis in Mice by IL-6/STAT3 Signaling Pathway Open
Ulcerative colitis (UC) is a chronic, idiopathic and relapsing inflammatory disease of the gastrointestinal tract that has a prolonged disease duration. Lindera aggregata (Sims) Kosterm. is a traditional Chinese herb which has been used to…
View article: Cyproterone acetate acts as a disruptor of the aryl hydrocarbon receptor
Cyproterone acetate acts as a disruptor of the aryl hydrocarbon receptor Open
View article: Ethyl acetate extract from Inula�helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway
Ethyl acetate extract from Inula�helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway Open
Sesquiterpene lactones are bioactive compounds that have been identified as responsible for the anticancer activity of the medicinal herb, Inula helenium L. (IHL). However, the mechanisms of action involved in the anti‑pancreatic cancer ac…
View article: Effects of Linderae radix extracts on a rat model of alcoholic liver injury
Effects of Linderae radix extracts on a rat model of alcoholic liver injury Open
Traditional treatments have a poor effect on alcoholic liver diseases. Linderae radix (LR), the dried root of Lindera aggregata (Sims) Kosterm., has been frequently used in traditional Chinese medicine for treating various diseases,…