Congai Chen
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View article: From Brain Imaging Phenotypes to Vascular Dementia Subtypes: A Comprehensive Mendelian Randomization Study
From Brain Imaging Phenotypes to Vascular Dementia Subtypes: A Comprehensive Mendelian Randomization Study Open
View article: Huanglian Jiedu decoction alleviates ischemia‐induced cerebral injury in rats by mitigating <scp>NET</scp> formation and activiting <scp>GABAergic</scp> synapses
Huanglian Jiedu decoction alleviates ischemia‐induced cerebral injury in rats by mitigating <span>NET</span> formation and activiting <span>GABAergic</span> synapses Open
Huanglian Jiedu decoction (HLJD) has been used to treat ischemic stroke in clinic. However, the detailed protective mechanisms of HLJD on ischemic stroke have yet to be elucidated. The aim of this study is to elucidate the underlying pharm…
View article: Refined Qingkailing protects the in vitro neurovascular unit against oxygen–glucose deprivation and re-oxygenation-induced injury
Refined Qingkailing protects the in vitro neurovascular unit against oxygen–glucose deprivation and re-oxygenation-induced injury Open
Since the proposal of the neurovascular unit (NVU) theory, it has become almost mandatory for neuroprotective medicines against ischaemic stroke (IS) to focus on this unit. Refined Qingkailing (RQKL) is a compound composed of hyodeoxycholi…
View article: Qinzhizhudan Formula Attenuates Inflammation in Microglia Polarization of Vascular Dementia Rats by Inhibiting MyD88/NFκB Signaling Pathway: Through Integrating Net-Work Pharmacology and Experimental Validation
Qinzhizhudan Formula Attenuates Inflammation in Microglia Polarization of Vascular Dementia Rats by Inhibiting MyD88/NFκB Signaling Pathway: Through Integrating Net-Work Pharmacology and Experimental Validation Open
View article: Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods
Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods Open
Background: Qinzhi Zhudan Formula (QZZD), optimized from Angong Niuhuang Wan, consists of Radix Scutellariae , Fructus Gardeniae and Pulvis Fellis Suis . We had investigated the neuroprotective effects of QZZD and its active components, an…
View article: Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway
Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway Open
Ischemic stroke (IS) can disrupt various types of brain cells in the neurovascular unit (NVU) at both the structural and functional levels. Therefore, NVU is considered to be a more comprehensive target for the treatment of IS. It is neces…
View article: Exploring the Pharmacological Mechanism of Bezoar on Cerebral Ischemic Stroke using a Network Pharmacology Approach
Exploring the Pharmacological Mechanism of Bezoar on Cerebral Ischemic Stroke using a Network Pharmacology Approach Open
Background Ischemic stroke is a common clinical disease limited by its time window for treatment. In addition to its high mortality rate, only one treatment currently exists for ischemic stroke. Nonetheless, traditional Chinese medicine is…