Conghui Shen
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Author Swipe
View article: Development of an efficient mice model of cancer‐associated cardiac cachexia
Development of an efficient mice model of cancer‐associated cardiac cachexia Open
Background Cancer‐associated cardiac cachexia (CACC) refers to cardiac injury in cancer patients in a malignant state, but preclinical animal models remain inadequately developed. Methods This study established CACC models in C57BL/6J and …
View article: Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport
Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport Open
View article: SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice
SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice Open
Statins therapy is efficacious in diminishing the risk of major cardiovascular events in diabetic patients. However, our research has uncovered a correlation between the prolonged administration of statins and an elevated risk of myocardia…
View article: Expression Pattern and Function of Cardiac Pigment Epithelium-derived Factor During Cardiac Development
Expression Pattern and Function of Cardiac Pigment Epithelium-derived Factor During Cardiac Development Open
Objective: This study aims to describe the expression profile and role of cardiac pigment epithelium-derived factor (PEDF) during cardiac development.
View article: A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis
A novel mouse model of PEDF-associated serious liver inflammation, hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis Open
View article: Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice
Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice Open
Diabetic cardiomyopathy is a primary myocardial injury induced by diabetes with complex pathogenesis. In this study, we identify disordered cardiac retinol metabolism in type 2 diabetic male mice and patients characterized by retinol overl…
View article: Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice
Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice Open
View article: Expression Patterns and Functions of Cardiac Pigment Epithelium-Derived Factor During Cardiac Development
Expression Patterns and Functions of Cardiac Pigment Epithelium-Derived Factor During Cardiac Development Open
Objective: This study describes the expression profiles and roles of cardiac pigment epithelium-derived factor (PEDF) during cardiac development. Methods: Gene datasets from the Gene Expression Omnibus (GEO) database were used to analyze t…
View article: Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch Open
As a biological pump, the heart needs to consume a substantial amount of energy to maintain sustained beating. Myocardial energy metabolism was recently reported to be related to the loss of proliferative capacity in cardiomyocytes (CMs). …
View article: Limited Heart Rate Reduction Promotes Cardiac Regeneration Through Stimulation of the Metabolic Pattern Switch
Limited Heart Rate Reduction Promotes Cardiac Regeneration Through Stimulation of the Metabolic Pattern Switch Open