Congjing Wang
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View article: The role of SRPK1-mediated phosphorylation of SR proteins in the chromatin configuration transition of mouse germinal vesicle oocytes
The role of SRPK1-mediated phosphorylation of SR proteins in the chromatin configuration transition of mouse germinal vesicle oocytes Open
Meiotic resumption in mammalian oocytes involves nuclear and organelle structural changes, notably the chromatin configuration transition from a non-surrounding nucleolus (NSN) to surrounding nucleolus (SN) in germinal vesicle oocytes. In …
View article: Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages
Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages Open
Background Oocyte maturation arrest results in female infertility and the genetic etiology of this phenotype remains largely unknown. Previous studies have proven that cyclins play a significant role in the cell cycle both in meiosis and m…
View article: Integrative proteome analysis implicates aberrant RNA splicing in impaired developmental potential of aged mouse oocytes
Integrative proteome analysis implicates aberrant RNA splicing in impaired developmental potential of aged mouse oocytes Open
Aging has many effects on the female reproductive system, among which decreased oocyte quality and impaired embryo developmental potential are the most important factors affecting female fertility. However, the mechanisms underlying oocyte…
View article: Correction to: Expanding the Genetic and Phenotypic Spectrum of Female Infertility Caused by TUBB8 Mutations
Correction to: Expanding the Genetic and Phenotypic Spectrum of Female Infertility Caused by TUBB8 Mutations Open
View article: Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos
Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos Open
Zygotic genomic activation (ZGA) is a landmark event in the maternal-to-zygotic transition (MZT), and the regulation of ZGA by maternal factors remains to be elucidated. In this study, the depletion of maternal ring finger protein 114 (RNF…
View article: The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway
The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway Open
PAT1 homolog 2 (PATL2), encoding an RNA-binding protein, is a repressor involved in the translational regulation of maternal mRNAs during oocyte maturation. Previous studies have reported mutations in PATL2 those led to female infertility …
View article: Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human
Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human Open
The human zona pellucida (ZP) is a highly organized glycoprotein matrix that encircles oocytes and plays an essential role in successful reproduction. Previous studies have reported that mutations in human ZP1, ZP2 and ZP3 influence their …