Congjun Yu
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View article: Catalytic C-Demethylation of Phenols and Anilines Enabled by a Removable Mono-Directing Group
Catalytic C-Demethylation of Phenols and Anilines Enabled by a Removable Mono-Directing Group Open
The activation of inert carbon–carbon (C–C) bonds remains a major challenge in organic synthesis, particularly for unstrained and nonpolar systems such as aryl–methyl (Ar–Me) bonds. Existing strategies predominantly rely on bidentate chela…
View article: Site-Selective Catalytic Saturation of Unactivated Arenes via Directed 6π-Activation
Site-Selective Catalytic Saturation of Unactivated Arenes via Directed 6π-Activation Open
The directing group-based strategy has been highly effective for site-selective functionalization of alkenes, carbonyls, C−H bonds, C−C bonds, etc., but not yet known for unactivated aromatic π-systems. On the other hand, catalytic hydroge…
View article: Direct Dehydrogenative Access to Unsymmetrical Phenones
Direct Dehydrogenative Access to Unsymmetrical Phenones Open
The first non‐directed dehydrogenative phenone coupling method of methylarenes with aromatic C−H bonds, displaying a large substrate scope, is herein reported. This reaction represents a far more direct atom‐ and step‐efficient alternative…
View article: Phosphine-Catalyzed Dearomative [3 + 2] Cycloaddition of Benzoxazoles with a Cyclopropenone
Phosphine-Catalyzed Dearomative [3 + 2] Cycloaddition of Benzoxazoles with a Cyclopropenone Open
The triphenylphosphine-catalyzed dearomative [3 + 2] cycloaddition of benzoxazoles with 1,2-diphenylcyclopropenone is herein described. The reaction scope, mechanism, and possible future applications of this rare organocatalyzed cycloaddit…
View article: TEMPO-mediated late stage photochemical hydroxylation of biaryl sulfonium salts
TEMPO-mediated late stage photochemical hydroxylation of biaryl sulfonium salts Open
The late stage photochemical hydroxylation of biaryl sulfonium salts was enabled with a TEMPO derivative as a simple oxygen source, in metal free conditions.
View article: Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran
Electrochemical Dehydrogenative Acetalization Protection of Alcohols with Tetrahydrofuran Open
A mild, facile, and environmentally friendly electrochemical protocol for the C(sp 3 )−H/O−H cross dehydrogenative coupling between various alcohols and tetrahydrofuran with H 2 evolution is herein reported. This synthetic strategy does no…
View article: Photochemical (Hetero-)Arylation of Aryl Sulfonium Salts
Photochemical (Hetero-)Arylation of Aryl Sulfonium Salts Open
The construction of (hetero)biaryls, which are ubiquitous scaffolds among medical substances, functional materials, and agrochemicals, constitutes a key application of cross-coupling methods. However, these usually require multiple synthet…
View article: Electro‐Oxidative Selective Esterification of Methylarenes and Benzaldehydes
Electro‐Oxidative Selective Esterification of Methylarenes and Benzaldehydes Open
A mild and green electro‐oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Mor…
View article: Emerging unconventional organic solvents for C–H bond and related functionalization reactions
Emerging unconventional organic solvents for C–H bond and related functionalization reactions Open
Recognizing and classifying the recently appeared reactivity enabling unconventional solvents is the main objective of this tutorial review, for applications in the field of C–H bond functionalization reactions.
View article: New strategies to achieve selective cross-dehydrogenative couplings (CDCs)
New strategies to achieve selective cross-dehydrogenative couplings (CDCs) Open
In this thesis, we have developed several high selective CDCs with different strategies. The first one is by using a Cu(II) catalyst, we developed an ortho-selective aminomethylation of phenols. In this reaction, an arguably broad variety …
View article: Regioselective Oxidative Arylation of Fluorophenols
Regioselective Oxidative Arylation of Fluorophenols Open
A metal free and highly regioselective oxidative arylation reaction of fluorophenols is described. The relative position of the fluoride leaving group (i.e., ortho or para ) controls the 1,2 or 1,4 nature of the arylated quinone product, l…
View article: Cu‐Catalyzed Cross‐Dehydrogenative <i>ortho</i>‐Aminomethylation of Phenols
Cu‐Catalyzed Cross‐Dehydrogenative <i>ortho</i>‐Aminomethylation of Phenols Open
A highly selective Cu II ‐catalyzed cross‐dehydrogenative ortho ‐aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp 2 )−C(sp 3 ) coupling products were obtained in moderate to excellent yields under m…
View article: A Novel Method to Prepare Multisubstituted Pyrazoles
A Novel Method to Prepare Multisubstituted Pyrazoles Open
This paper reports a new strategy to construct multisubstituted pyrazoles from hydrazine and 1,3-diketone which is generated through α-oxo gold carbene using readily available propargyl alcohol.The carbene formation and C-C bond migration …