Conglin Ren
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View article: Survival benefit of resection of early TN-stage osteosarcoma in patients with lung metastasis: A retrospective study
Survival benefit of resection of early TN-stage osteosarcoma in patients with lung metastasis: A retrospective study Open
Background: Osteosarcoma (OS) is a highly malignant bone tumor with poor prognosis, especially for patients with lung metastasis (LM). The guidelines do not recommend resection surgery for OS patients with LM. However, some studies showed …
View article: The efficacy of statins in the treatment of rheumatoid arthritis: A systematic review and meta-analysis
The efficacy of statins in the treatment of rheumatoid arthritis: A systematic review and meta-analysis Open
Background: A large body of research has investigated the use of statins in rheumatoid arthritis (RA); however, the therapeutic effects of statins remain uncertain. Thus, we designed a systematic review and meta-analysis to evaluate the ro…
View article: Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells degranulation model and network pharmacology
Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells degranulation model and network pharmacology Open
Background: Baicalin is widely used in clinical practice. The present study aimed to assess the underlying mechanism of baicalin in treatment of atherosclerosis (AS) with the help of network pharmacology, molecular docking and experimental…
View article: Single‐cell RNA‐seq reveals altered NK cell subsets and reduced levels of cytotoxic molecules in patients with ankylosing spondylitis
Single‐cell RNA‐seq reveals altered NK cell subsets and reduced levels of cytotoxic molecules in patients with ankylosing spondylitis Open
Ankylosing spondylitis (AS) is an autoimmune disease with unknown aetiology. To unravel the mechanisms mediating AS pathogenesis, we profiled peripheral blood mononuclear cells (PBMCs) from AS patients and healthy subjects using 10X single…
View article: Additional file 1 of Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology
Additional file 1 of Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology Open
Additional file 1.
View article: Additional file 2 of Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology
Additional file 2 of Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology Open
Additional file 2.
View article: CD96 Downregulation Promotes the Immune Response of CD4 T Cells and Associates with Ankylosing Spondylitis
CD96 Downregulation Promotes the Immune Response of CD4 T Cells and Associates with Ankylosing Spondylitis Open
Inhibitory receptors (IRs) play an indispensable role in regulating T cell activation and expansion. This study is aimed at exploring the correlation between IRs and ankylosing spondylitis (AS). Bioinformatics analysis of two datasets (GSE…
View article: Efficacy and Safety of Wenbu Zhibi Granule in Patients with Ankylosing Spondylitis: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial
Efficacy and Safety of Wenbu Zhibi Granule in Patients with Ankylosing Spondylitis: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Open
Background. Ankylosing spondylitis (AS) is a chronic disease in which the column is the main lesion. It is caused by a combination of genetic and environmental factors, mainly involving the axial skeleton, resulting in column rigidity and …
View article: Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co‐expression network module
Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co‐expression network module Open
Stroke is one of the leading causes of patients' death and long‐term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all strokes. Differential genes and weighted gene co‐expression network analysis (WGCNA) in mal…
View article: Peer Review #3 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.3)"
Peer Review #3 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.3)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #4 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.2)"
Peer Review #4 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.2)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #3 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)"
Peer Review #3 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #1 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.2)"
Peer Review #1 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.2)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #3 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.2)"
Peer Review #3 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.2)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #2 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)"
Peer Review #2 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #4 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)"
Peer Review #4 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Peer Review #1 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)"
Peer Review #1 of "Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis (v0.1)" Open
Background.Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS.In the present study, various bioinformatics analysis methods were comprehensively a…
View article: Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis
Identification of immune related cells and crucial genes in the peripheral blood of ankylosing spondylitis by integrated bioinformatics analysis Open
Background Ankylosing spondylitis (AS) is a progressive rheumatic disease and studies reveal that the immune system is critical for the pathogenesis of AS. In the present study, various bioinformatics analysis methods were comprehensively …
View article: Efficacy And Safety of Wenbu Zhibi Granule In Patients With Ankylosing Spondylitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Efficacy And Safety of Wenbu Zhibi Granule In Patients With Ankylosing Spondylitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Open
Background: Ankylosing spondylitis (AS) is a chronic disease in which the column is the main lesion. It is caused by a combination of genetic and environmental factors, mainly involving the axial skeleton, resulting in column rigidity and …
View article: Peer Review #3 of "Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification (v0.3)"
Peer Review #3 of "Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification (v0.3)" Open
Background.The pathogenesis of rheumatoid arthritis (RA) is complex.This study aimed to identify diagnostic biomarkers and transcriptional regulators that underlie RA based on bioinformatics analysis and experimental verification.Material …
View article: Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification
Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification Open
Background The pathogenesis of rheumatoid arthritis (RA) is complex. This study aimed to identify diagnostic biomarkers and transcriptional regulators that underlie RA based on bioinformatics analysis and experimental verification. Materia…
View article: Peer Review #3 of "Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification (v0.2)"
Peer Review #3 of "Identification of diagnostic genes and vital microRNAs involved in rheumatoid arthritis: based on data mining and experimental verification (v0.2)" Open
Background.The pathogenesis of rheumatoid arthritis (RA) is complex.This study aimed to identify diagnostic biomarkers and transcriptional regulators that underlie RA based on bioinformatics analysis and experimental verification.Material …
View article: Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome
Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome Open
Background. Acute coronary syndrome (ACS) has a high incidence and mortality rate. Early detection and intervention would provide clinical benefits. This study aimed to reveal hub genes, transcription factors (TFs), and microRNAs (miRNAs) …
View article: Comprehensive Bioinformatics Analysis Reveals Hub Genes and Inflammation State of Rheumatoid Arthritis
Comprehensive Bioinformatics Analysis Reveals Hub Genes and Inflammation State of Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, which has not been thoroughly cured yet, and standardized treatment is helpful for alleviating clinical symptoms. Here, various bioinformatics analysis …
View article: Acupuncture Therapy plus Hyaluronic Acid Injection for Knee Osteoarthritis: A Meta‐Analysis of Randomized Controlled Trials
Acupuncture Therapy plus Hyaluronic Acid Injection for Knee Osteoarthritis: A Meta‐Analysis of Randomized Controlled Trials Open
Objective . This meta‐analysis aimed to investigate the effectiveness of acupuncture therapy plus hyaluronic acid injection versus hyaluronic acid injection alone for patients with knee osteoarthritis. Methods . Relevant randomized control…