Chengliang Deng
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View article: Precision approach to diabetic peripheral neuropathy: modified nerve decompression surgery and MNGF treatment
Precision approach to diabetic peripheral neuropathy: modified nerve decompression surgery and MNGF treatment Open
Background Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of diabetes, often resulting in pain, sensory loss, and lower limb ulcers. While traditional nerve decompression (ND) surgery can alleviate symptoms,…
View article: An endoplasmic reticulum stress-responsive nanocomposite hydrogel for diabetic wound healing through a fibroblast-immune cell dual regulation hub
An endoplasmic reticulum stress-responsive nanocomposite hydrogel for diabetic wound healing through a fibroblast-immune cell dual regulation hub Open
Diabetic wounds exhibit excessive endoplasmic reticulum stress (ERS), which can lead to fibroblast dysfunction, abnormal natural killer (NK) cell activation, and imbalanced macrophage polarization. ERS exerts a bidirectional regulatory eff…
View article: Potential roles of histone deacetylases in diabetic wound healing
Potential roles of histone deacetylases in diabetic wound healing Open
Diabetic foot ulcer is the most prevalent and serious lower-limb complication among individuals with diabetes, and it significantly contributes to the incidence of non-traumatic amputations. The repeated failure of diabetic wounds to heal …
View article: Skin-derived vascularized lymph node transfer combining with liposuction in stages for bilateral lower extremity lymphedema: a case report
Skin-derived vascularized lymph node transfer combining with liposuction in stages for bilateral lower extremity lymphedema: a case report Open
Bilateral lower extremity lymphedema (LEL) significantly impairs patients’ quality of life. A 66-year-old female patient, who developed bilateral LEL following cervical cancer surgery (classified as International Society of Lymphology stag…
View article: A Novel Lymphosome-Based Long-Lasting Rat Tail Model of Lymphedema
A Novel Lymphosome-Based Long-Lasting Rat Tail Model of Lymphedema Open
Secondary extremity lymphedema is a chronic and progressive condition caused by obstructed lymphatic drainage, commonly following lymphadenectomy, infection, or trauma. Rodent models are preferred for experimental lymphedema research due t…
View article: Long-term follow-up of modified shunt-restricted instep arterialized venous flap for reconstruction of hand defects
Long-term follow-up of modified shunt-restricted instep arterialized venous flap for reconstruction of hand defects Open
Background Instep arterialized venous flaps (iAVF) are suitable for reconstructing soft tissue defects of the hand while concurrently fulfilling aesthetic requirements. However, iAVF still face challenges such as unstable survival rates an…
View article: Identification of novel hub genes and pathways predictive of fibrosis progression in cancer-related lymphedema through integrated multi-omics
Identification of novel hub genes and pathways predictive of fibrosis progression in cancer-related lymphedema through integrated multi-omics Open
Background Cancer-related lymphedema (CRL) is a common chronic complication following cancer treatment, characterized by impaired lymphatic drainage, interstitial fluid retention, and progressive fibrosis. Although the mechanisms of hypert…
View article: Decellularized lymph node scaffolds accelerate restoration of lymphatic drainage in rat hind limb lymphedema
Decellularized lymph node scaffolds accelerate restoration of lymphatic drainage in rat hind limb lymphedema Open
Background There is a lack of effective lymphedema prevention methods. The objective of this study was to investigate the ability of decellularized lymph nodes (dLNs) transplantation to prevent hindlimb lymphedema. Methods Porcine dLNs wer…
View article: From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment
From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment Open
Mesenchymal Stem Cells (MSCs) and their secreted extracellular vesicles (EVs), particularly exosomes (Exos), have garnered significant attention for their potential in tissue repair, fibrosis, and tumor therapy. However, the therapeutic ef…
View article: Case Report: Surgical management of primary lymphedema with a novel PROX1 mutation involving upper and lower limbs
Case Report: Surgical management of primary lymphedema with a novel PROX1 mutation involving upper and lower limbs Open
Background Primary lymphedema (PL) is a chronic condition characterized by abnormal swelling of tissues due to impaired lymphatic drainage, leading to increased deposition of adipose tissue and fibrosis. Although several pathogenic variant…
View article: Association between monocyte-lymphocyte ratio and diabetic peripheral neuropathy in the US populations: a population-based study
Association between monocyte-lymphocyte ratio and diabetic peripheral neuropathy in the US populations: a population-based study Open
Background Inflammation has emerged as a significant contributor to the development and progression of diabetic peripheral neuropathy (DPN), and the monocyte-lymphocyte ratio (MLR) is a novel inflammatory marker in peripheral blood. Howeve…
View article: [An overview of integrated surgical management for secondary lower limb lymphedema guided by algorithms].
[An overview of integrated surgical management for secondary lower limb lymphedema guided by algorithms]. Open
Secondary lymphedema is a chronic progressive disease caused by lymphatic flow obstruction due to surgery, trauma, infection, etc., leading to inflammation, edema, adipose deposition, and fibrosis in subcutaneous tissue. While early, stand…
View article: [Clinical efficacy of vascularized lymph node transfer combined with lymphatico-venous anastomosis in treating unilateral upper limb lymphedema after radical mastectomy for breast cancer].
[Clinical efficacy of vascularized lymph node transfer combined with lymphatico-venous anastomosis in treating unilateral upper limb lymphedema after radical mastectomy for breast cancer]. Open
Objective: To investigate the clinical efficacy of vascularized lymph node transfer (VLNT) combined with lymphatico-venous anastomosis (LVA) in treating unilateral upper limb lymphedema after radical mastectomy for breast cancer. Methods: …
View article: [Clinical application and Zunyi Classification of free anterolateral thigh chimeric flaps].
[Clinical application and Zunyi Classification of free anterolateral thigh chimeric flaps]. Open
Objective: To summarize the clinical application and Zunyi Classification of free anterolateral thigh chimeric flaps. Methods: This study was a retrospective observational study. From June 2021 to June 2024, 200 patients who underwent free…
View article: A novel cryopreservation solution for adipose tissue based on metformin
A novel cryopreservation solution for adipose tissue based on metformin Open
The TGM cryopreservation solution, containing metformin, greatly preserves adipose tissue, reduces apoptosis, and improves tissue retention rates. This solution was non-toxic and safe, making it well-suited for tissue cryopreservation in c…
View article: [Effect of different degrees of wound eversion sutures on scar formation at donor site of anterolateral thigh flaps: A prospective randomized controlled study].
[Effect of different degrees of wound eversion sutures on scar formation at donor site of anterolateral thigh flaps: A prospective randomized controlled study]. Open
Moderate everted closure may reduce the formation of hypertrophic scars at the incision site of the anterior lateral thigh flap to a certain extent.
View article: Microneedles in diabetic wound care: multifunctional solutions for enhanced healing
Microneedles in diabetic wound care: multifunctional solutions for enhanced healing Open
Diabetic wounds present a significant challenge in clinical treatment and are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, peripheral neuropathy, and a heightened risk of infection during the healing proc…
View article: Efficacy of Adipose Stromal Cells-Enriched High- Density Fat Graft Combined with BTX-A for Raynaud’s Phenomenon: A Prospective Cohort Study
Efficacy of Adipose Stromal Cells-Enriched High- Density Fat Graft Combined with BTX-A for Raynaud’s Phenomenon: A Prospective Cohort Study Open
Background: Conventional treatments for Raynaud’s phenomenon (RP) often show limited effectiveness due to their inability to address both vascular and inflammatory aspects. This study evaluates the combination of high-density fat grafting …
View article: A Novel Clinical-Grade Cryopreservation Solution for Adipose Tissue Based on Metformin
A Novel Clinical-Grade Cryopreservation Solution for Adipose Tissue Based on Metformin Open
Background Autologous fat grafting often needs multiple sessions due to low volume retention. Young adipose tissue demonstrates a more pronounced therapeutic effect; thus, the cryopreservation of adipose tissue of young origin is particula…
View article: Synchronous supraclavicular vascularized lymph node transfer and liposuction for gynecological cancer-related lower extremity lymphedema: A clinical comparative analysis of three different procedures
Synchronous supraclavicular vascularized lymph node transfer and liposuction for gynecological cancer-related lower extremity lymphedema: A clinical comparative analysis of three different procedures Open
For advanced GC-LEL, SLNF combined with liposuction is a preferred treatment, offering fewer complications, shorter operative time, and hospitalization.
View article: Combining antibiotic‐loaded bone cement‐based free vastus lateralis muscle‐sparing flap with split‐thickness skin grafts: A reliable strategy for reconstructing diabetic foot ulcers at non‐weight‐bearing areas
Combining antibiotic‐loaded bone cement‐based free vastus lateralis muscle‐sparing flap with split‐thickness skin grafts: A reliable strategy for reconstructing diabetic foot ulcers at non‐weight‐bearing areas Open
Diabetic foot ulcers (DFUs) present significant challenges due to their associated amputation rates, mortality, treatment complexity and excessive costs. Our earlier work introduced a wound surgical integrated treatment (WSIT) for DFUs, yi…
View article: Iliac crest bone distraction surgery for the treatment of thromboangiitis obliterans of lower limbs: A cohort-prospective preliminary study
Iliac crest bone distraction surgery for the treatment of thromboangiitis obliterans of lower limbs: A cohort-prospective preliminary study Open
Background Tibial cortex transverse transport (TTT) surgery presents favorable outcomes for treating thromboangiitis obliterans (TAO). However, TTT is associated with complications and requires prolonged bed rest, impacting patients' quali…
View article: Metformin Eliminates Lymphedema in Mice by Alleviating Inflammation and Fibrosis: Implications for Human Therapy
Metformin Eliminates Lymphedema in Mice by Alleviating Inflammation and Fibrosis: Implications for Human Therapy Open
Background: Secondary lymphedema is a chronic, disabling disease affecting more than 50% of patients with cancer and lacking effective pharmacologic treatment even for early to middle disease stages. Metformin reportedly exerts anti-inflam…
View article: [Research advances on the role of microRNA engineered exosomes in diabetic wounds].
[Research advances on the role of microRNA engineered exosomes in diabetic wounds]. Open
Diabetic wounds are a common complication in patients with diabetes, which is difficult to treat. Current treatment methods for diabetic wounds include debridement, functional dressing coverage, negative pressure therapy, bone cement filli…