Explanipedia

Greater benefits of immediate nirmatrelvir-ritonavir initiation for post-COVID outcomes: a population-based retrospective cohort study Open

Ka Chun Chong, Yuchen Wei, Carlos King Ho Wong, Xi Xiong, Huwen Wang , et al. · 2025

Nirmatrelvir-ritonavir is generally recommended to be initiated within five days of COVID-19 symptom onset. This study examined the association between the timing of nirmatrelvir-ritonavir initiation and post-acute outcomes more precisely …

SARS-CoV-2 rebound and post-acute mortality and hospitalization among patients admitted with COVID-19: cohort study Open

Ka Chun Chong, Yuchen Wei, Katherine Min Jia, Christopher Boyer, Guozhang Lin , et al. · 2025

Recent investigations have demonstrated a relationship between the persistence of SARS-CoV-2 and post-COVID-19 conditions. Building upon a potential connection between SARS-CoV-2 persistence and early virologic rebound, we examine the asso…

Evaluation of dengue fever vulnerability in south and southeast asian countries: A multidimensional approach Open

Yawen Wang, Conglu Li, Shi Zhao, Guozhang Lin, Xiaoting Jiang , et al. · 2025

Post-pandemic excess mortality of COVID-19 in Hong Kong: a retrospective study Open

Kehang Li, Yuchen Wei, Chi Tim Hung, Carlos King Ho Wong, Xi Xiong , et al. · 2025

Health and Medical Research Fund.

Association of ambient temperature and influenza-like illness with acute appendicitis: an ecological study using 22-year data Open

Onchee Yu, Xiaoting Jiang, Conglu Li, Yawen Wang, Yuchen Wei , et al. · 2025

Background While acute appendicitis poses a significant disease burden worldwide, its etiology is not completely known. Previous studies have separately demonstrated its associations with ambient temperature and seasonal influenza, but the…

Association of cold weather and influenza infection with stroke: a 22-year time-series analysis Open

Zihan Yang, Yuchen Wei, Xiaoting Jiang, Conglu Li, Guozhang Lin , et al. · 2025

Despite the significant adverse health effects and economic burden of stroke inpatients, there has been a paucity of research specifically analyzing and quantifying the association between meteorological factors, air pollutants, influenza …

Short- and long-term comparative effectiveness of nirmatrelvir/ritonavir and molnupiravir in asthma patients: a cohort study Open

Guozhang Lin, Yuchen Wei, Zihao Guo, Huwen Wang, Kate Ching Ching Chan , et al. · 2025

Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID-19 outcomes among outpatients: a target trial emulation investigation Open

Yuchen Wei, Christopher Boyer, Katherine Min Jia, Guozhang Lin, Huwen Wang , et al. · 2025

Limited studies compared the effectiveness of nirmatrelvir/ritonavir and molnupiravir against a control group on post-COVID-19 conditions. Our study examined the association of nirmatrelvir/ritonavir and molnupiravir with post-acute mortal…

COVID-19 vaccination modified the effect of nirmatrelvir–ritonavir on post-acute mortality and rehospitalization: a retrospective cohort study Open

Huwen Wang, Yuchen Wei, Guozhang Lin, Christopher Boyer, Katherine Min Jia , et al. · 2024

While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction or its impact on post-acute outcomes. This…

Environmental factors, influenza activity, and sepsis: An analysis of 22-year hospital admission data Open

Guozhang Lin, Conglu Li, Xiaoting Jiang, Yuchen Wei, Ka Chun Chong · 2024

Exposure to cold temperature and influenza infections increased the risk of myocarditis hospitalization: A time-series analysis Open

Wenxiao Zheng, Guozhang Lin, Conglu Li, Xiaoting Jiang, Yuchen Wei , et al. · 2024

Association between asthma and COVID-19 severity during Omicron epidemic: a retrospective cohort study using real-world data Open

Huwen Wang, Xiaoting Jiang, Kate Ching Ching Chan, Yuchen Wei, Chi Tim Hung , et al. · 2024

Air pollutants, seasonal influenza, and acute otitis media in children: a population-based analysis using 22-year hospitalization data Open

Conglu Li, Xiaoting Jiang, Yuchen Wei, Yawen Wang, Xiang Qian Lao , et al. · 2024

Effect of environmental exposome and influenza infection on febrile seizure in children over 22 years: a time series analysis Open

Xiaoting Jiang, Conglu Li, Qianying Yue, Yuchen Wei, Yawen Wang , et al. · 2024

Febrile seizures are convulsions predominately occurring in young children. The effects of various exposomes, including influenza infection and external environmental factors, on febrile seizures have not been well-studied. In this study, …

Association between meteorological variations and the superspreading potential of SARS-CoV-2 infections Open

Ka Chun Chong, Shi Zhao, Chi Tim Hung, Katherine Min Jia, Janice Ho , et al. · 2024

This study demonstrated a link between meteorological factors and the superspreading potential of COVID-19. We speculated that cold weather and rainy days reduced the social activities of individuals minimizing the interaction with others …

Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study Open

Huwen Wang, Yuchen Wei, Chi Tim Hung, Guozhang Lin, Xiaoting Jiang , et al. · 2024

Projection of dengue fever transmissibility under climate change in South and Southeast Asian countries Open

Yawen Wang, Conglu Li, Shi Zhao, Yuchen Wei, Kehang Li , et al. · 2024

Vector-borne infectious disease such as dengue fever (DF) has spread rapidly due to more suitable living environments. Considering the limited studies investigating the disease spread under climate change in South and Southeast Asia, this …

Relationship between temperature variability and daily hospitalisations in Hong Kong over two decades Open

Kehang Li, Yawen Wang, Xiaoting Jiang, Conglu Li, Jinjian Chen , et al. · 2023

Our population-based study highlighted that TV-related health burden, usually regarded as minimal compared to other environmental factors, should receive more attention and be addressed in future relevant health policies, especially for vu…

Impact of ambient temperature, air pollutants, and seasonal influenza on febrile seizure in children Open

Xiaoting Jiang, Conglu Li, Qianying Yue, Yuchen Wei, Yawen Wang , et al. · 2023

BACKGROUND AND AIM: Febrile seizure is a kind of convulsion that mainly occurs among young children. The effects of various exposome including influenza infection and external environmental factors on febrile seizure have not been well-stu…

A population-based analysis on the relationship between air pollutants, influenza infection, and acute otitis media in children Open

Conglu Li, Xiaoting Jiang, Yuchen Wei, Yawen Wang, Xiang Qian Lao , et al. · 2023

BACKGROUND AND AIM: Acute otitis media (AOM) is the most common diagnosis for childhood acute illness, accounting for 13.6 million pediatric office visits annually. It is currently acknowledged as a bacterial complication of viral upper re…

Impact of Influenza Infection and Environmental Factors on Sepsis Open

Guozhang Lin, Conglu Li, Xiaoting Jiang, Yuchen Wei, Ka Chun Chong · 2023

BACKGROUND AND AIM: The influences of influenza infections and environmental factors on sepsis have been examined. However, no previous studies have attempted to simultaneously quantify their impact on sepsis. In this study, we aimed to ev…

Projection of Dengue Fever Infection Under Climate Change: A Modelling Study Open

Yawen Wang, Conglu Li, Xiaoting Jiang, Shi Yin, Chao Ren , et al. · 2023

Impact of climate change on dengue fever epidemics in South and Southeast Asian settings: A modelling study Open

Yawen Wang, Shi Zhao, Yuchen Wei, Kehang Li, Xiaoting Jiang , et al. · 2023

The potential for dengue fever epidemic due to climate change remains uncertain in tropical areas. This study aims to assess the impact of climate change on dengue fever transmission in four South and Southeast Asian settings. We collected…

Changes in all-cause and cause-specific excess mortality before and after the Omicron outbreak of COVID-19 in Hong Kong Open

Ka Chun Chong, Paul K.S. Chan, Chi Tim Hung, Carlos King Ho Wong, Xi Xiong , et al. · 2023

Our results highlighted the averted mortality before 2022 among the elderly and patients with non-COVID-19 respiratory diseases, due to indirect benefits from stringent non-pharmaceutical interventions. The high excess mortality during the…

Relationship between antidepressants and severity of SARS-CoV-2 Omicron infection: a retrospective cohort study using real-world data Open

Huwen Wang, Yuchen Wei, Chi Tim Hung, Xiaoting Jiang, Conglu Li , et al. · 2023

This research was supported by Health and Medical Research Fund [grant numbers COVID190105, COVID19F03, INF-CUHK-1], Collaborative Research Fund of University Grants Committee [grant numbers C4139-20G], National Natural Science Foundation …

Estimating the serial intervals of SARS‐CoV‐2 Omicron BA.4, BA.5, and BA.2.12.1 variants in Hong Kong Open

Zihao Guo, Shi Zhao, Carrie Ho Kwan Yam, Conglu Li, Xiaoting Jiang , et al. · 2023

Empirical evidence on the epidemiological characteristics of the emerged SARS‐CoV‐2 variants could shed light on the transmission potential of the virus and strategic outbreak control planning. In this study, by using contact tracing data …

Impact of extreme weather on dengue fever infection in four Asian countries: A modelling analysis Open

Yawen Wang, Yuchen Wei, Kehang Li, Xiaoting Jiang, Conglu Li , et al. · 2022

The rapid spread of dengue fever (DF) infection has posed severe threats to global health. Environmental factors, such as weather conditions, are believed to regulate DF spread. While previous research reported inconsistent change of DF ri…

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