Congran Li
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View article: Machine Learning-Enabled Insights: Dihydromyricetin’s Novel Role in Inhibiting the TGF-β/ALK5 Signaling Cascade for the Treatment of Pulmonary Fibrosis
Machine Learning-Enabled Insights: Dihydromyricetin’s Novel Role in Inhibiting the TGF-β/ALK5 Signaling Cascade for the Treatment of Pulmonary Fibrosis Open
View article: <i>In vitro</i> anti- <i>Helicobacter pylori</i> activity of ilaprazole used alone and in combination with other components of quadruple therapy
<i>In vitro</i> anti- <i>Helicobacter pylori</i> activity of ilaprazole used alone and in combination with other components of quadruple therapy Open
Ilaprazole, a proton pump inhibitor, has been approved and marketed in Korea and China for the treatment of gastric ulcer, duodenal ulcer, gastroesophageal reflux disease, and erosive esophagitis. This study evaluated the in vitro antibact…
View article: Pentoxifylline, a Non-Antibiotic Drug, Promotes Adaptation of Clinical Isolates of <i>Staphylococcus aureus</i> via Modulating c-di-AMP Signaling
Pentoxifylline, a Non-Antibiotic Drug, Promotes Adaptation of Clinical Isolates of <i>Staphylococcus aureus</i> via Modulating c-di-AMP Signaling Open
This study investigated how Staphylococcus aureus adapts under pentoxifylline (PTX) therapy through analyzing three phylogenetically related isolates (L1, L2, L3) from a bacteremia patient. Whole genome sequencing revealed L1 contained a 2…
View article: Low-power versus high-power laser for holmium laser enucleation of prostate: systematic review and meta-analysis
Low-power versus high-power laser for holmium laser enucleation of prostate: systematic review and meta-analysis Open
Although LP-HoLEP may be associated with lower EE, it demonstrates comparable efficacy and safety. Further high-quality studies are necessary to strengthen the evidence base and promote broader clinical adoption of LP-HoLEP.
View article: Silent or low expression of blaTEM and blaSHV suggests potential for targeted proteomics in clinical detection of β-lactamase-related antimicrobial resistance
Silent or low expression of blaTEM and blaSHV suggests potential for targeted proteomics in clinical detection of β-lactamase-related antimicrobial resistance Open
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View article: Deletion of the Mycobacterium tuberculosis cyp138 gene leads to changes in membrane-related lipid composition and antibiotic susceptibility
Deletion of the Mycobacterium tuberculosis cyp138 gene leads to changes in membrane-related lipid composition and antibiotic susceptibility Open
Introduction Mycobacterium tuberculosis ( Mtb ), the main cause of tuberculosis (TB), has brought a great burden to the world's public health. With the widespread use of Mtb drug-resistant strains, the pressure on anti-TB treatment is incr…
View article: An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China
An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China Open
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries. In this context, one of the biggest concerns is whether enough new antibacterial drugs are being discovered and develope…
View article: Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae
Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae Open
Polymyxin B and polymyxin E (colistin) are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacte…
View article: Protective effect of the novel cyclic peptide ASK0912 on mice with sepsis induced by Acinetobacter baumannii
Protective effect of the novel cyclic peptide ASK0912 on mice with sepsis induced by Acinetobacter baumannii Open
ASK0912 can not only improve the survival rate, hypothermia, lower the bacterial loads in the organs and blood, but also alleviate the pathophysiological manifestations such as intravascular coagulation abnormalities, organ damages, and im…
View article: Evaluation of Agar Dilution Method in Susceptibility Testing of Polymyxins for Enterobacteriaceae and Non-Fermentative Rods: Advantages Compared to Broth Microdilution and Broth Macrodilution
Evaluation of Agar Dilution Method in Susceptibility Testing of Polymyxins for Enterobacteriaceae and Non-Fermentative Rods: Advantages Compared to Broth Microdilution and Broth Macrodilution Open
An accurate and reliable susceptibility testing method for polymyxins is urgently needed not only for the clinical laboratory but also for new polymyxin-like lipopeptide development. Reference broth microdilution (rBMD), which was the reco…
View article: Parallel Reaction Monitoring Mass Spectrometry for Rapid and Accurate Identification of β-Lactamases Produced by Enterobacteriaceae
Parallel Reaction Monitoring Mass Spectrometry for Rapid and Accurate Identification of β-Lactamases Produced by Enterobacteriaceae Open
The increasing spread of drug-resistant bacterial strains presents great challenges to clinical antibacterial treatment and public health, particularly with regard to β-lactamase-producing Enterobacteriaceae . A rapid and accurate detectio…
View article: The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates
The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates Open
View article: Strategies for Rapid Identification of Acinetobacter baumannii Membrane Proteins and Polymyxin B’s Effects
Strategies for Rapid Identification of Acinetobacter baumannii Membrane Proteins and Polymyxin B’s Effects Open
Acinetobacter baumannii , especially multidrug resistant Acinetobacter baumannii , is a notable source of pressure in the areas of public health and antibiotic development. To overcome this problem, attention has been focused on membrane p…
View article: Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China
Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China Open
Introduction: The clinical and molecular characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in various provinces of China have been reported, however, there have been few reports in Hebei Province, North China. Methodology: The …
View article: Characterization of a hypervirulent multidrug-resistant ST23 Klebsiella pneumoniae carrying a bla IncFII plasmid and a pK2044-like plasmid
Characterization of a hypervirulent multidrug-resistant ST23 Klebsiella pneumoniae carrying a bla IncFII plasmid and a pK2044-like plasmid Open
View article: The Combined Antibacterial Effects of Sodium New Houttuyfonate and Berberine Chloride against Growing and Persistent Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus
The Combined Antibacterial Effects of Sodium New Houttuyfonate and Berberine Chloride against Growing and Persistent Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus Open
Background: Infections caused by drug-resistant Staphylococcus aureus , especially vancomycin-intermediate Staphylococcus aureus (VISA), leave clinicians with limited therapeutic options for treatment. Persister cells is a leading cause of…
View article: Modulation of BIN2 kinase activity by HY5 controls hypocotyl elongation in the light
Modulation of BIN2 kinase activity by HY5 controls hypocotyl elongation in the light Open
View article: Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria
Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria Open
View article: Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China
Clinical and microbiological characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in a hospital from North China Open
Background: The clinical and molecular characteristics of hypervirulent Klebsiella pneumoniae (hvKp) in various provinces of China have been reported, however, there have been few reports in Hebei Province, North China. Methods: The hvKp w…