Congxia Hu
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View article: Awareness and vaccination willingness of middle-aged and elderly individuals in Southwest China toward to herpes zoster vaccine
Awareness and vaccination willingness of middle-aged and elderly individuals in Southwest China toward to herpes zoster vaccine Open
The incidence of herpes zoster is increasing in China's aging society, and vaccination is the most effective preventive measure. However, vaccine hesitancy is a major obstacle. A survey was conducted among individuals aged 50 and above in …
View article: Long‐Term Effects of the COVID‐19 Open Strategy on the Mental Health of Chinese University Students: A Prospective Cohort Study
Long‐Term Effects of the COVID‐19 Open Strategy on the Mental Health of Chinese University Students: A Prospective Cohort Study Open
Background In December 2022, the Chinese government shifted its COVID‐19 prevention and control policy to full openness, leading to a widespread pandemic within a short period. This study aimed to examine the trajectories of stress, anxiet…
View article: A cross-sectional investigation of factors influencing mpox vaccine hesitancy for students in Southwest China
A cross-sectional investigation of factors influencing mpox vaccine hesitancy for students in Southwest China Open
From July to September 2023, China reported over 1, 400 confirmed cases of mpox transmitted mainly through sexual contact between males. Meanwhile, the percentage of men who have sex with men at universities in southwestern China is increa…
View article: Evaluation and comparison of immune responses induced by two Mpox mRNA vaccine candidates in mice
Evaluation and comparison of immune responses induced by two Mpox mRNA vaccine candidates in mice Open
The epidemic of Mpox virus (MPXV) from May 2022 was once declared as a Public Health Emergency of International Concern by the World Health Organization. Vaccines play an important role in prevention of infectious diseases, and mRNA vaccin…
View article: A Subunit Vaccine Candidate Composed of Mpox Virus A29L, M1R, A35R, and B6R Elicits Robust Immune Response in Mice
A Subunit Vaccine Candidate Composed of Mpox Virus A29L, M1R, A35R, and B6R Elicits Robust Immune Response in Mice Open
With no specific antiviral drugs and preventive vaccines against Mpox virus (MPXV), the epidemic has led to the declaration of a Public Health Emergency of International Concern. As a developmental direction for new vaccines, studies of su…
View article: BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate
BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate Open
Introduction: Spermatogenesis is sustained by the homeostasis of self-renewal and differentiation of undifferentiated spermatogonia throughout life, which is regulated by transcriptional and posttranscriptional mechanisms. B cell-specific …
View article: 2cChIP-seq and 2cMeDIP-seq: The Carrier-Assisted Methods for Epigenomic Profiling of Small Cell Numbers or Single Cells
2cChIP-seq and 2cMeDIP-seq: The Carrier-Assisted Methods for Epigenomic Profiling of Small Cell Numbers or Single Cells Open
Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) can profile genome-wide epigenetic marks associated with regulatory genomic elements. However, conventional ChIP-seq is challenging when examining limited num…
View article: Generation of a DNA-launched classical swine fever virus infectious clone packaged in bacterial artificial chromosome
Generation of a DNA-launched classical swine fever virus infectious clone packaged in bacterial artificial chromosome Open
Reverse genetics system offers powerful tool for the research of RNA viruses. The infectious clones of classical swine fever virus (CSFV) were commonly constructed either in high- or low-copy number plasmids and transcribed to infectious R…
View article: Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization Open
β-Adrenergic receptor (β-AR) signaling is a pathway controlling adaptive thermogenesis in brown or beige adipocytes. Here we investigate the biological roles of the transcription factor Foxp1 in brown/beige adipocyte differentiation and th…
View article: Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages
Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages Open
Classical swine fever virus (CSFV) replicates in macrophages and causes persistent infection. Despite its role in disastrous economic losses in swine industries, the molecular mechanisms underlying its pathogenesis are poorly understood. T…