Connie Fung
YOU?
Author Swipe
View article: Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape
Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape Open
Succinate produced by the commensal protist Tritrichomonas musculis ( T. mu ) stimulates chemosensory tuft cells, resulting in intestinal type 2 immunity. Tuft cells express the succinate receptor SUCNR1, yet this receptor does not mediate…
View article: Tuft cell-derived acetylcholine regulates epithelial fluid secretion
Tuft cell-derived acetylcholine regulates epithelial fluid secretion Open
Tuft cells are solitary chemosensory epithelial cells that can sense lumenal stimuli at mucosal barriers and secrete effector molecules to regulate the physiology and immune state of their surrounding tissue. In the small intestine, tuft c…
View article: Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish
Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish Open
Individuals homozygous for the Pi*Z allele of SERPINA1 (ZAAT) are susceptible to lung disease due to insufficient α1-antitrypsin secretion into the circulation and may develop liver disease due to compromised protein folding that leads to …
View article: Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape
Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape Open
Succinate produced by the commensal protist Tritrichomonas musculis ( T. mu ) stimulates chemosensory tuft cells, resulting in intestinal type 2 immunity. Tuft cells express the succinate receptor SUCNR1, yet this receptor does not mediate…
View article: An infection-activated redox switch promotes tumor growth
An infection-activated redox switch promotes tumor growth Open
Oxidative stress is a defining feature of most cancers, including those that stem from carcinogenic infections 1 . Reactive oxygen species (ROS) can drive tumor formation 2–4 , yet the molecular oxidation events that contribute to tumorige…
View article: High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach
High-resolution mapping reveals that microniches in the gastric glands control Helicobacter pylori colonization of the stomach Open
Lifelong infection of the gastric mucosa by Helicobacter pylori can lead to peptic ulcers and gastric cancer. However, how the bacteria maintain chronic colonization in the face of constant mucus and epithelial cell turnover in the stomach…