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View article: Early Division of the Paramedian Forehead Flap: A Systematic Review and Retrospective Analysis
Early Division of the Paramedian Forehead Flap: A Systematic Review and Retrospective Analysis Open
Objective To determine whether and when early division of the paramedian forehead flap may be safely performed. Data Sources PubMed (NLM), Scopus (Elsevier), and Embase (Elsevier). Methods A systematic search of PubMed, Scopus, and Embase …
View article: A Large Thyroid Goiter in a Newborn With Congenital Hypothyroidism: Timeline for Decrease in Size of Thyroid
A Large Thyroid Goiter in a Newborn With Congenital Hypothyroidism: Timeline for Decrease in Size of Thyroid Open
Congenital hypothyroidism rarely causes a clinically significant neck mass in newborns. We present the case of a newborn with congenital hypothyroidism and significantly enlarged goiter and discuss imaging considerations and medical and su…
View article: Bilateral Vocal Fold Paralysis in a Patient With Congenital MYOD1 Myopathy
Bilateral Vocal Fold Paralysis in a Patient With Congenital MYOD1 Myopathy Open
Congenital bilateral vocal fold paralysis (BVFP) is a rare but significant cause of morbidity in pediatric otolaryngology. The differential diagnosis is expansive, with common etiologies including birth trauma, brainstem neoplasms, and neu…
View article: Atezolizumab alone or in combination did not demonstrate a favorable risk-benefit profile in myelodysplastic syndrome
Atezolizumab alone or in combination did not demonstrate a favorable risk-benefit profile in myelodysplastic syndrome Open
We present primary results from the phase 1b GO29754 study evaluating the safety and tolerability of atezolizumab, a programmed death-ligand 1 inhibitor, alone and in combination with azacitidine, a hypomethylating agent (HMA), in patients…
View article: A <scp>Phase I</scp> dose‐escalation study of <scp>DCLL9718S</scp>, an antibody‐drug conjugate targeting <scp>C</scp>‐type lectin‐like molecule‐1 (<scp>CLL</scp>‐1) in patients with acute myeloid leukemia
A <span>Phase I</span> dose‐escalation study of <span>DCLL9718S</span>, an antibody‐drug conjugate targeting <span>C</span>‐type lectin‐like molecule‐1 (<span>CLL</span>‐1) in patients with acute myeloid leukemia Open
Acute myeloid leukemia (AML) is an aggressive malignancy with especially dismal outcomes in relapsed or refractory patients. C-type lectin-like molecule-1 (CLL1) is a transmembrane glycoprotein expressed on the surface of AML blast cells.1…
View article: Emergency Medicine Physicians’ Knowledge and Perceptions of Training, Education, and Resources in Eating Disorders
Emergency Medicine Physicians’ Knowledge and Perceptions of Training, Education, and Resources in Eating Disorders Open
Background: Eating disorders, specifically anorexia nervosa, have one of the highest mortality rates of all mental illnesses.(1) Knowledge and perceptions of patients with eating disorders (ED) in the Emergency Medicine (EM) specialty is n…
View article: Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
Promotion of growth factor signaling as a critical function of β-catenin during HCC progression Open
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. β-catenin is widely thought to be a major oncogene in HCC based on the frequency of mutations associated with aberrant Wnt signaling in HCC pati…
View article: Abstract QS25: The Impact of Ptosis, Breast Size, and Surgical History on Complications in Autologous Breast Reconstruction
Abstract QS25: The Impact of Ptosis, Breast Size, and Surgical History on Complications in Autologous Breast Reconstruction Open
INTRODUCTION: Previous studies have attempted to elucidate risk factors in autologous breast reconstruction associated with wound complications and outcome with varying results. BMI is a risk factor that has been associated with a variety …
View article: Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression
Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression Open
Prolonged exit from quiescence by hematopoietic stem cells (HSCs) progressively impairs their homeostasis in the bone marrow through an unidentified mechanism. We show that Rb proteins, which are major enforcers of quiescence, maintain HSC…