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View article: Disproportionality signal for myopia associated with aripiprazole: Analysis of the FAERS database and review of the literature
Disproportionality signal for myopia associated with aripiprazole: Analysis of the FAERS database and review of the literature Open
View article: A real-world pharmacovigilance analysis of ALK inhibitor-associated pleural and pericardial effusion using the FDA Adverse Events Reporting System (FAERS) database from 2013 to 2024
A real-world pharmacovigilance analysis of ALK inhibitor-associated pleural and pericardial effusion using the FDA Adverse Events Reporting System (FAERS) database from 2013 to 2024 Open
Introduction The advent of anaplastic lymphoma kinase (ALK) inhibitors has revolutionized the treatment of ALK-rearranged malignancies, establishing these agents as vital components of precision oncology. Despite their proven efficacy in p…
View article: Immune-mediated enterocolitis is associated with immune checkpoint inhibitors: A pharmacovigilance study from the FDA Adverse Event Reporting System (FAERS) database
Immune-mediated enterocolitis is associated with immune checkpoint inhibitors: A pharmacovigilance study from the FDA Adverse Event Reporting System (FAERS) database Open
Purpose Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by demonstrating significant efficacy across multiple malignancies. However, by interfering with immune regulatory pathways, they can lead to immune-related a…
View article: Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk
Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk Open
The study reveals significant variations in meningioma risk associated with different hormonal therapies. Certain progestogens and estrogens present notably higher risks, emphasizing the need for personalized risk assessments in hormonal t…
View article: Disproportionality analysis of ALK inhibitor-induced hemolytic adverse events: a pharmacovigilance study using the FDA Adverse Event Reporting System Database
Disproportionality analysis of ALK inhibitor-induced hemolytic adverse events: a pharmacovigilance study using the FDA Adverse Event Reporting System Database Open
Anaplastic lymphoma kinase (ALK) inhibitors have transformed treatment for ALK-rearranged malignancies, particularly non-small cell lung cancer, by disrupting oncogenic signalling. However, hematologic adverse effects, including hemolysis,…
View article: A Real-World Pharmacovigilance Analysis of Lorlatinib-Associated Metabolic Effects Using the FDA Adverse Events Reporting System (FAERS) Database From 2013 to 2024
A Real-World Pharmacovigilance Analysis of Lorlatinib-Associated Metabolic Effects Using the FDA Adverse Events Reporting System (FAERS) Database From 2013 to 2024 Open
These findings highlight the need for proactive monitoring and management of metabolic side effects in patients receiving lorlatinib. A multidisciplinary approach-incorporating pharmacologic interventions, lifestyle modifications, and regu…
View article: Risk of Hair Loss with Semaglutide for Weight Loss
Risk of Hair Loss with Semaglutide for Weight Loss Open
GLP-1 (glucagon-like peptide-1) agonists including semaglutide are some of the most prescribed medications in the world. Many recent studies have quantified their adverse events with a focus on gastrointestinal adverse events. However, no …
View article: Non-Metastatic Pure Pancreatic Hepatoid Carcinoma with Genomic and Transcriptomic Analysis: A Case Report
Non-Metastatic Pure Pancreatic Hepatoid Carcinoma with Genomic and Transcriptomic Analysis: A Case Report Open
Background: Pancreatic hepatoid carcinoma (PHC) is a rare and poorly characterized malignancy, with approximately 50 reported cases in the literature. Pure PHC, which lacks any features of adenocarcinoma or neuroendocrine differentiation, …
View article: Hepatobiliary Adverse Events Associated With the <scp>KRAS p.G12C</scp> Inhibitor Sotorasib
Hepatobiliary Adverse Events Associated With the <span>KRAS p.G12C</span> Inhibitor Sotorasib Open
Purpose The p.G12C mutation in KRAS is commonly found in many cancers and was previously untreatable until drugs like sotorasib were developed. However, up to 15% of patients treated with sotorasib have experienced hepatobiliary adverse ev…
View article: Quetiapine is associated with pancreatitis: A real-world pharmacovigilance study
Quetiapine is associated with pancreatitis: A real-world pharmacovigilance study Open
Quetiapine, an atypical antipsychotic widely prescribed for conditions including schizophrenia and bipolar disorder has been associated with a potential risk of pancreatitis. This study aimed to quantify the association between quetiapine …
View article: Hepatobiliary Adverse Events Associated with Pembrolizumab: A Pharmacovigilance Study from the FDA Adverse Event Reporting System (FAERS) Database
Hepatobiliary Adverse Events Associated with Pembrolizumab: A Pharmacovigilance Study from the FDA Adverse Event Reporting System (FAERS) Database Open
Background: Immuno-oncology has transformed cancer treatment, with immune checkpoint inhibitors (ICIs) like pembrolizumab playing a key role. While highly effective, these therapies can also cause immune-related adverse events. This study …
View article: Cardiovascular Adverse Events Associated with Prostate Cancer Treatment: A Disproportionality Analysis from the Food and Drug Administration Adverse Event Reporting System Database
Cardiovascular Adverse Events Associated with Prostate Cancer Treatment: A Disproportionality Analysis from the Food and Drug Administration Adverse Event Reporting System Database Open
Background/Objectives: Several drugs used to treat prostate cancer have been reported to cause cardiovascular adverse events, and this study sought to identify the real-world risk. Methods: This study utilized real-world data from the FAER…
View article: Development of an Automated, Ultra-Rapid Bottom-Up Proteomics Workflow Utilizing Alginate-Based Hydrogels
Development of an Automated, Ultra-Rapid Bottom-Up Proteomics Workflow Utilizing Alginate-Based Hydrogels Open
A new approach to sample preparation and enzymatic digestion in bottom-up proteomics has been developed using alginate-based hydrogel entrapment of enzymes. This hydrogel facilitates rapid and room-temperature digestions with multienzyme c…
View article: Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes
Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes Open
The Long-Read Personalized OncoGenomics (POG) dataset comprises a cohort of 189 patient tumors and 41 matched normal samples sequenced using the Oxford Nanopore Technologies PromethION platform. This dataset from the POG program and the Ma…
View article: Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database
Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database Open
This study aimed to identify the 25 most prevalent adverse events (AEs) associated with FDA-approved immune checkpoint inhibitors (ICIs)—specifically, PD-1, PD-L1, CTLA-4, and LAG-3 inhibitors—using data from the FDA Adverse Events Reporti…
View article: Immune-Related Adverse Events Associated with Atezolizumab: Insights from Real-World Pharmacovigilance Data
Immune-Related Adverse Events Associated with Atezolizumab: Insights from Real-World Pharmacovigilance Data Open
The advancement of immuno-oncology has brought about a significant shift in cancer treatment methods, with antibody-based immune checkpoint inhibitors like atezolizumab leading the way in this regard. However, the use of this checkpoint bl…
View article: What proteomics has taught us about honey bee ( <i>Apis mellifera</i> ) health and disease
What proteomics has taught us about honey bee ( <i>Apis mellifera</i> ) health and disease Open
The Western honey bee, Apis mellifera , is currently navigating a gauntlet of environmental pressures, including the persistent threat of parasites, pathogens, and climate change – all of which compromise the vitality of honey bee colonies…
View article: Development of automated proteomic workflows utilizing silicon-based coupling agents
Development of automated proteomic workflows utilizing silicon-based coupling agents Open
Automated methods for enzyme immobilization via 4-triethoxysilylbutyraldehyde (TESB) derived silicone-based coupling agents were developed. TESB and its oxidized derivative, 4-triethoxysilylbutanoic acid (TESBA), were determined to be the …
View article: Development of Automated Proteomic Workflows Utilizing Silicon-Based Coupling Agents
Development of Automated Proteomic Workflows Utilizing Silicon-Based Coupling Agents Open
Automated methods for enzyme immobilization via 4-triethoxysilylbutyraldehyde (TESB) derived silicone-based coupling agents were developed. TESB and its oxidized derivative, 4-triethoxysilylbutanoic acid (TESBA), were determined to be the …
View article: Ocular adverse events following <scp>CAR‐T</scp> cell therapy: A pharmacovigilance study and systematic review
Ocular adverse events following <span>CAR‐T</span> cell therapy: A pharmacovigilance study and systematic review Open
The rise of immuno‐oncology, including the use of chimeric antigen receptor T‐cell (CAR‐T) therapy is bringing in a new wave of cancer treatments, particularly in hematologic malignancies. However, data on their adverse events, particularl…
View article: Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes
Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes Open
The Long-read POG dataset comprises a cohort of 189 patient tumours and 41 matched normal samples sequenced using the Oxford Nanopore Technologies PromethION platform. This dataset from the Personalized Oncogenomics (POG) program and the M…
View article: Capillary Electrophoresis-Based Immobilized Enzyme Microreactor Utilizing Pepsin for Bottom-Up Proteomics
Capillary Electrophoresis-Based Immobilized Enzyme Microreactor Utilizing Pepsin for Bottom-Up Proteomics Open
In this study, we introduced a novel method for pepsin immobilization through investigation into three different coupling reactions, aiming to simplify peptide mapping. We initially determined the optimal enzyme-to-substrate ratio to be 1:…
View article: Long-Read Sequencing of an Advanced Cancer Cohort Resolves Rearrangements, Unravels Haplotypes, and Reveals Methylation Landscapes
Long-Read Sequencing of an Advanced Cancer Cohort Resolves Rearrangements, Unravels Haplotypes, and Reveals Methylation Landscapes Open
View article: 303 Suboxone for Opioid Use Disorder: Reduction in Mortality and Increased Remission
303 Suboxone for Opioid Use Disorder: Reduction in Mortality and Increased Remission Open