Connor R. Ferguson
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View article: Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume
Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume Open
Some astronauts on International Space Station missions experience neuroophthalmological pathologies as part of spaceflight associated neuro-ocular syndrome (SANS). Strict head-down tilt bed rest (HDTBR) is a spaceflight analog that replic…
View article: Author Response: The Posterior Displacement of the Bruch's Membrane Opening: A Surprising Finding in Spaceflight-Associated Neuro-Ocular Syndrome
Author Response: The Posterior Displacement of the Bruch's Membrane Opening: A Surprising Finding in Spaceflight-Associated Neuro-Ocular Syndrome Open
View article: Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension
Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension Open
This study showed substantial differences in the degree of disc edema and the pattern of ocular deformations between IIH and SANS. The precise cause for these differences is unknown but suggests that there may be fundamental differences in…
View article: Incidence and Progression of Chorioretinal Folds During Long-Duration Spaceflight
Incidence and Progression of Chorioretinal Folds During Long-Duration Spaceflight Open
Importance The primary contributing factor for development of chorioretinal folds during spaceflight is unknown. Characterizing fold types that develop and tracking their progression may provide insight into the pathophysiology of spacefli…
View article: Discrepancy between the crop yield goal rate and the optimum nitrogen rates for maize production in Mississippi
Discrepancy between the crop yield goal rate and the optimum nitrogen rates for maize production in Mississippi Open
The varying influence of the environment on N supply and demand dictates the need for annually updated fertilizer N recommendations. Currently, crop yield goal (CYG) methods are used by 34 land grant universities, including Mississippi Sta…
View article: Identification of Factors Associated With the Development of Optic Disc Edema During Spaceflight
Identification of Factors Associated With the Development of Optic Disc Edema During Spaceflight Open
Importance Approximately 70% of crew members who complete long-duration missions to the International Space Station develop signs of optic disc edema, a hallmark finding of spaceflight-associated neuro-ocular syndrome. The onset and magnit…
View article: Changes in Optic Nerve Head and Retinal Morphology During Spaceflight and Acute Fluid Shift Reversal
Changes in Optic Nerve Head and Retinal Morphology During Spaceflight and Acute Fluid Shift Reversal Open
Importance Countermeasures that reverse the headward fluid shift experienced in weightlessness have the potential to mitigate spaceflight-associated neuro-ocular syndrome. This study investigated whether use of the countermeasure lower-bod…
View article: Reproducibility of Systolic Strain in Mice Using Cardiac Magnetic Resonance Feature Tracking of Black-Blood Cine Images
Reproducibility of Systolic Strain in Mice Using Cardiac Magnetic Resonance Feature Tracking of Black-Blood Cine Images Open
View article: Association of Structural Changes in the Brain and Retina After Long-Duration Spaceflight
Association of Structural Changes in the Brain and Retina After Long-Duration Spaceflight Open
These results help characterize spaceflight-associated neuro-ocular syndrome and the physiologic associations of headward fluid shifts with outcomes during spaceflight on the central nervous system. The possibly weak association between in…
View article: Changes in the Optic Nerve Head and Choroid Over 1 Year of Spaceflight
Changes in the Optic Nerve Head and Choroid Over 1 Year of Spaceflight Open
This report documents the late development of mild optic disc edema in 1 crew member and the progressive development of choroidal folds and optic disc edema in another crew member over the duration of 1 year in low Earth orbit aboard the I…
View article: Association of Long-Duration Spaceflight With Anterior and Posterior Ocular Structure Changes in Astronauts and Their Recovery
Association of Long-Duration Spaceflight With Anterior and Posterior Ocular Structure Changes in Astronauts and Their Recovery Open
This study found that spaceflight-associated peripapillary optic disc edema and choroid thickening were observed bilaterally and occurred in both sexes. In addition, this study documented substantial peripapillary choroid thickening during…
View article: Submacular Choroid Thickness Increases During Long-Duration Spaceflight
Submacular Choroid Thickness Increases During Long-Duration Spaceflight Open
The Spaceflight Associated Neuro-ocular Syndrome (SANS) is characterized by the development of optic disc edema, choroidal folds, cotton-wool spots, globe flattening, and/or refractive error changes greater than or equal to 0.75D during lo…
View article: Effects of short‐term mild hypercapnia during head‐down tilt on intracranial pressure and ocular structures in healthy human subjects
Effects of short‐term mild hypercapnia during head‐down tilt on intracranial pressure and ocular structures in healthy human subjects Open
Many astronauts experience ocular structural and functional changes during long-duration spaceflight, including choroidal folds, optic disc edema, globe flattening, optic nerve sheath diameter (ONSD) distension, retinal nerve fiber layer t…
View article: Effects of mild hypercapnia and head-down tilt on translaminar pressure and ocular structures in healthy human subjects
Effects of mild hypercapnia and head-down tilt on translaminar pressure and ocular structures in healthy human subjects Open
View article: Measurement of Acute Changes in Choroid Thickness in Healthy Eyes During Posture Change Using Optical Coherence Tomography
Measurement of Acute Changes in Choroid Thickness in Healthy Eyes During Posture Change Using Optical Coherence Tomography Open
The Visual Impairment and Intracranial Pressure (VIIP) syndrome affects 60% of astronauts returning from long-duration missions and is characterized by structural and functional changes of the eye (3). Upon entry into weightlessness, appro…