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View article: A Click Chemistry Approach for Developing Organelle-Directed Photocytotoxic Ruthenium(II) Probes
A Click Chemistry Approach for Developing Organelle-Directed Photocytotoxic Ruthenium(II) Probes Open
Transition metal complexes are versatile probes for cellular imaging and sensing. While the interactions of Ru(II) polypyridyl complexes with macromolecules such as DNA have long been studied, their application in cells or tissues has been…
View article: A Click Chemistry Approach for Developing Organelle-Directed Photocytotoxic Ruthenium(II) Probes
A Click Chemistry Approach for Developing Organelle-Directed Photocytotoxic Ruthenium(II) Probes Open
Transition metal complexes are versatile probes for cellular imaging and sensing. While the interactions of Ru(II) polypyridyl complexes with macromolecules such as DNA have long been studied, their application in cells or tissues has been…
View article: Manganese single-atom modification of MOF-808 for catalytic nerve agent and simulant degradation
Manganese single-atom modification of MOF-808 for catalytic nerve agent and simulant degradation Open
Single-atom Mn sites on MOF-808 catalyze sarin simulant degradation under solid, unbuffered conditions. Spectroscopic and computational results show altered product binding that mitigates poisoning and sustains reactivity.
View article: Targeting Mitochondrial Guanine Quadruplexes for Photoactivatable Chemotherapy in Hypoxic Environments
Targeting Mitochondrial Guanine Quadruplexes for Photoactivatable Chemotherapy in Hypoxic Environments Open
A first example of a mitochondrial G‐quadruplex (mitoG4s) targeted Ru(II) photooxidant complex is reported. The complex, Ru‐TAP‐PDC3 induces photodamage toward guanine quadruplexes (G4s) located in the mitochondrial genome under hypoxic an…
View article: Targeting Mitochondrial Guanine Quadruplexes for Photoactivatable Chemotherapy in Hypoxic Environments
Targeting Mitochondrial Guanine Quadruplexes for Photoactivatable Chemotherapy in Hypoxic Environments Open
A first example of a mitochondrial G‐quadruplex (mitoG4s) targeted Ru(II) photooxidant complex is reported. The complex, Ru‐TAP‐PDC3 induces photodamage toward guanine quadruplexes (G4s) located in the mitochondrial genome under hypoxic an…
View article: Excited-State Dynamics Leading Either to Triplet Formation or Coordinative Expansion following Photolysis of Cu(II)-Porphyrins: A DFT, TD-DFT, Luminescence and Femtosecond Time-Resolved Absorbance Study
Excited-State Dynamics Leading Either to Triplet Formation or Coordinative Expansion following Photolysis of Cu(II)-Porphyrins: A DFT, TD-DFT, Luminescence and Femtosecond Time-Resolved Absorbance Study Open
The photophysical properties of Cu(II) complexes with 5,10,15,20-meso-tetrakis(phenyl)porphyrin and 5,10,15,20-meso-tetrakis(N-methylpyridium-4-yl)porphyrin are examined via the luminescence and femtosecond time-resolved absorbance methods…
View article: Excited-State Dynamics Leading either to Triplet Formation or Coordinative Expansion following Photolysis of Cu(II)-5,10,15,20-<em>meso-tetrakis</em>(phenyl)porphyrin or Cu(II)-5,10,15,20-<em>meso-tetrakis</em>(N-methylpyridium-4-yl)porphyrin: A DFT, TD-DFT, Luminescence and Femtosecond Time-Resolved Absorbance Study
Excited-State Dynamics Leading either to Triplet Formation or Coordinative Expansion following Photolysis of Cu(II)-5,10,15,20-<em>meso-tetrakis</em>(phenyl)porphyrin or Cu(II)-5,10,15,20-<em>meso-tetrakis</em>(N-methylpyridium-4-yl)porphyrin: A DFT, TD-DFT, Luminescence and Femtosecond Time-Resolved Absorbance Study Open
The photophysical properties of Cu(II) complexes with 5,10,15,20-meso-tetrakis(phenyl)porphyrin and 5,10,15,20-meso-tetrakis(N-methylpyridium-4-yl)porphyrin were examined by luminescence and femtosecond time-resolved absorbance methods res…
View article: X-RAY SPECTROSCOPY STUDIES OF Ti-BASED METAL ORGANIC FRAMEWORKS
X-RAY SPECTROSCOPY STUDIES OF Ti-BASED METAL ORGANIC FRAMEWORKS Open
View article: Selective, Disruptive Luminescent Ru(II) Polypyridyl Probes of G-Quadruplex
Selective, Disruptive Luminescent Ru(II) Polypyridyl Probes of G-Quadruplex Open
Sensors capable of transducing G-quadruplex DNA binding are important both in solution and for imaging and interrogation in cellulo. Ru(II)-based light switches incorporating dipyridylphenazine (dppz) ligands are effective probes for recog…
View article: Correction: Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics
Correction: Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics Open
Correction for ‘Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics’ by Páraic M. Keane et al. , Phys. Chem. Chem.…
View article: CCDC 1407620: Experimental Crystal Structure Determination
CCDC 1407620: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics
Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics Open
Time-resolved IR spectra of porphyrins bound to biomolecules are reported. DFT calculations aid porphyrin vibration assignment while distinctive IR bands reveal interactions with therapeutic targets such as quadruplex DNA and proteins in H…
View article: Adenine Radical Cation Formation by a Ligand-Centered Excited State of an Intercalated Chromium Polypyridyl Complex Leads to Enhanced DNA Photo-oxidation
Adenine Radical Cation Formation by a Ligand-Centered Excited State of an Intercalated Chromium Polypyridyl Complex Leads to Enhanced DNA Photo-oxidation Open
Assessment of the DNA photo-oxidation and synthetic photocatalytic activity of chromium polypyridyl complexes is dominated by consideration of their long-lived metal-centered excited states. Here we report the participation of the excited …
View article: Ionization – dissociation of methane in ultrashort 400 nm and 800 nm laser fields
Ionization – dissociation of methane in ultrashort 400 nm and 800 nm laser fields Open
The effect of laser wavelength on the dissociation mechanisms in methane is examined over a broad range of intensities for both 800 nm and 400 nm laser fields. It is found that, at lower laser intensities, the dissociation pathways identif…
View article: Exploiting a Neutral BODIPY Copolymer as an Effective Agent for Photodynamic Antimicrobial Inactivation
Exploiting a Neutral BODIPY Copolymer as an Effective Agent for Photodynamic Antimicrobial Inactivation Open
We report the synthesis and photophysical properties of a neutral BODIPY photosensitizing copolymer (poly-8-(4-hydroxymethylphenyl)-4,4-difluoro-2,6-diethynyl-4-bora-3a,4a-diaza-s-indacene) containing ethynylbenzene links between th…
View article: Explaining the role of water in the “light-switch” probe for DNA intercalation: Modelling water loss from [Ru(phen)2(dppz)]2+•2H2O using DFT and TD-DFT methods
Explaining the role of water in the “light-switch” probe for DNA intercalation: Modelling water loss from [Ru(phen)2(dppz)]2+•2H2O using DFT and TD-DFT methods Open
The photophysics of [Ru(1,10-phenanthroline)2(dipyrido[3,2−1:2′,3′-c]phenazine)]2+ and [Ru(1,10-phenanthroline)2(dipyrido[3,2−1:2′,3′-c]phenazine)]2+•2H2O are investigated by Density Functional and Time-Dependent Density Functional methods…
View article: A Time-Resolved Spectroscopic Investigation of a Novel BODIPY Copolymer and Its Potential Use as a Photosensitiser for Hydrogen Evolution
A Time-Resolved Spectroscopic Investigation of a Novel BODIPY Copolymer and Its Potential Use as a Photosensitiser for Hydrogen Evolution Open
A novel 4,4-difuoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) copolymer with diethynylbenzene has been synthesised, and its ability to act as a photosensitiser for the photocatalytic generation of hydrogen was investigated by time-resolved sp…
View article: Photo-activated CO-release in the amino tungsten Fischer carbene complex, [(CO)5WC(NC4H8)Me], picosecond time resolved infrared spectroscopy, time-dependent density functional theory, and an antimicrobial study
Photo-activated CO-release in the amino tungsten Fischer carbene complex, [(CO)5WC(NC4H8)Me], picosecond time resolved infrared spectroscopy, time-dependent density functional theory, and an antimicrobial study Open
View article: Spectro-electrochemical Studies on [Ru(TAP)<sub>2</sub>(dppz)]<sup>2+</sup>—Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides
Spectro-electrochemical Studies on [Ru(TAP)<sub>2</sub>(dppz)]<sup>2+</sup>—Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides Open
[Ru(TAP)2(dppz)]2+ (TAP = 1,4,5,8-tetraazaphenanthrene; dppz = dipyrido[3,2- a:2',3'- c]phenazine) is known to photo-oxidize guanine in DNA. Whether this oxidation proceeds by direct photoelectron transfer or by proto…
View article: Photoelectrocatalytic H<sub>2</sub> evolution from integrated photocatalysts adsorbed on NiO
Photoelectrocatalytic H<sub>2</sub> evolution from integrated photocatalysts adsorbed on NiO Open
A new approach to increasing the faradaic efficiency of dye-sensitised photocathodes for H2 evolution from water is described, using integrated photocatalysts based on a ruthenium 4,4′-diethoxycarboxy-2,2′-bipyridine chromophore…
View article: A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage Open
Free radical generation is an inevitable consequence of aerobic existence and is implicated in a wide variety of pathological conditions including cancer, cardiovascular disease, ageing and neurodegenerative disorder. Free radicals can, ho…
View article: Photo‐ and Electrochemical Properties of a CO<sub>2</sub> Reducing Ruthenium–Rhenium Quaterpyridine‐Based Catalyst
Photo‐ and Electrochemical Properties of a CO<sub>2</sub> Reducing Ruthenium–Rhenium Quaterpyridine‐Based Catalyst Open
The bridging ligand 2,2′,5′,3′′,6′′,2′′′‐quaterpyridine was utilised to tether [(bpy) 2 Ru] 2+ and [Re(CO) 3 Cl] subunits for the purpose of photocatalytic CO 2 reduction. The photophysics and electrochemistry of the complex and associated…
View article: Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination
Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination Open
In order to expand the current repertoire of cancer treatments and to help circumvent limitations associated with resistance, the identification of new metallodrugs with high potency and novel mechanisms of action is of significant importa…
View article: Polypyridyl substituted BODIPY derivatives; water switchable imaging probes that exhibit halogen substituent dependent localisation in live cells
Polypyridyl substituted BODIPY derivatives; water switchable imaging probes that exhibit halogen substituent dependent localisation in live cells Open
The synthesis and photophysical properties of water responsive 1,10-phenanthrolyl and 2,2′-bipyridyl substituted BODIPY derivatives prepared as lipid probes for cell imaging are reported.
View article: Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)<sub>2</sub>(dppz)]<sup>2+</sup> light-switch compound in solution and when bound to DNA
Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)<sub>2</sub>(dppz)]<sup>2+</sup> light-switch compound in solution and when bound to DNA Open
Strikingly different TRIR spectra are recorded for the complex in D2O or CD3CN or when DNA-bound.
View article: CCDC 1038710: Experimental Crystal Structure Determination
CCDC 1038710: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: An investigation into the photochemistry of, and the electrochemically induced CO-loss from, [(CO)<sub>5</sub>MC(OMe)Me](M = Cr or W) using low-temperature matrix isolation, picosecond infrared spectroscopy, cyclic voltammetry, and time-dependent density functional theory
An investigation into the photochemistry of, and the electrochemically induced CO-loss from, [(CO)<sub>5</sub>MC(OMe)Me](M = Cr or W) using low-temperature matrix isolation, picosecond infrared spectroscopy, cyclic voltammetry, and time-dependent density functional theory Open
The photophysics and photochemistry of [(CO)5MC(OMe)Me] (M = Cr or W) were investigated.