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View article: A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis
A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis Open
Sulfation is a widely used strategy in nature to modify the solubility, polarity, and biological activities of molecules. The enzymes catalyzing sulfation, sulfotransferases (STs), are typically highly specific to a single sulfation site i…
View article: Discovery of a Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads
Discovery of a Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads Open
Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein, we report a high-th…
View article: Probing Antimicrobial Activity and Mechanism of Action of a Bile Acid-Derived Antibiotic
Probing Antimicrobial Activity and Mechanism of Action of a Bile Acid-Derived Antibiotic Open
Antibiotics have revolutionized medicine, saving countless lives since the introduction of penicillin. However, antimicrobial resistance has challenged their efficacy, prompting ongoing efforts to develop new antibiotics. This study explor…
View article: Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads
Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads Open
Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein we report a high-thr…
View article: Discovery and Biosynthesis of Sulfenicin and Its New-to-Nature Acylsulfenic Acid Functional Group
Discovery and Biosynthesis of Sulfenicin and Its New-to-Nature Acylsulfenic Acid Functional Group Open
Life’s organic molecules are built with diverse functional groups that enable biology by fine tuning intimate connections through time and space. As such, the discovery of new-to-nature functional groups can expand our understanding of the…
View article: Discovery and Heterologous Expression of Trilenodin, an Antimicrobial Lasso Peptide with a Unique Tri‐Isoleucine Motif
Discovery and Heterologous Expression of Trilenodin, an Antimicrobial Lasso Peptide with a Unique Tri‐Isoleucine Motif Open
Lasso peptides are an increasingly relevant class of peptide natural products with diverse biological activities, intriguing physical properties, and unique chemical structures. Most characterized lasso peptides have been from Actinobacter…
View article: Refactoring and Heterologous Expression of Class III Lanthipeptide Biosynthetic Gene Clusters Lead to the Discovery of <i>N</i>,<i>N</i>-Dimethylated Lantibiotics from Firmicutes
Refactoring and Heterologous Expression of Class III Lanthipeptide Biosynthetic Gene Clusters Lead to the Discovery of <i>N</i>,<i>N</i>-Dimethylated Lantibiotics from Firmicutes Open
Class III lanthipeptides are an emerging subclass of lanthipeptides, representing an underexplored trove of new natural products with potentially broad chemical diversity and important biological activity. Bioinformatic analysis of class I…