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View article: Development of three-colour FRET cascade for force sensing of the putative RIAM-vinculin interaction in fibroblasts
Development of three-colour FRET cascade for force sensing of the putative RIAM-vinculin interaction in fibroblasts Open
Förster resonance energy transfer (FRET) enables the measurement of molecular interactions and conformational dynamics in biological systems. FRET-cascade, a multistep energy transfer system involving three fluorophores, enables spatial an…
View article: Development of three-color FRET measurement of force-dependent sensing of RIAM-Vinculin interactions in focal adhesions
Development of three-color FRET measurement of force-dependent sensing of RIAM-Vinculin interactions in focal adhesions Open
Förster resonance energy transfer (FRET) is a powerful technique for probing molecular interactions and conformational changes in biological systems. Cascade-FRET, a multistep energy transfer system involving three fluorophores, enables sp…
View article: In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells
In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells Open
Cardiac myosin binding protein-C (cMyBP-C) is a thick filament–associated regulatory protein frequently found mutated in patients suffering from hypertrophic cardiomyopathy (HCM). Recent in vitro experiments have highlighted the functional…
View article: Development of a high-speed line-scanning fluorescence lifetime imaging microscope for biological imaging
Development of a high-speed line-scanning fluorescence lifetime imaging microscope for biological imaging Open
We report the development of a novel line-scanning microscope capable of acquiring high-speed time-correlated single-photon counting (TCSPC)-based fluorescence lifetime imaging microscopy (FLIM) imaging. The system consists of a laser-line…
View article: Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors
Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors Open
The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLCTPR). He…
View article: Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors
Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors Open
The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLC TPR ). …