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View article: Explainable machine learning identifies features and thresholds predictive of immunotherapy response
Explainable machine learning identifies features and thresholds predictive of immunotherapy response Open
Background Immunotherapy has improved patient survival for multiple cancer types, including melanoma. While a variety of molecular features have been linked to response to immune checkpoint inhibitors (ICI) treatment, clinically establishe…
View article: Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples from Advanced Non-Small Cell Lung Cancer for Whole Genome, Whole Exome and Comprehensive Panel Sequencing
Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples from Advanced Non-Small Cell Lung Cancer for Whole Genome, Whole Exome and Comprehensive Panel Sequencing Open
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is often the only source of tumor tissue from patients with advanced, inoperable lung cancer. EBUS-TBNA aspirates are used for the diagnosis, staging, and genomic…
View article: A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer Open
The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its known role in tumor desmoplasia. Using small-molec…
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location. Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal melanoma occurs in the eyes; mucosal melanoma occurs in internal mu…
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location. Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal melanoma occurs in the eyes; mucosal melanoma occurs in internal mu…
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes Open
Supplementary Data from Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
View article: <i>streammd</i> : fast low-memory duplicate marking using a Bloom filter
<i>streammd</i> : fast low-memory duplicate marking using a Bloom filter Open
Summary Identification of duplicate templates is a common preprocessing step in bulk sequence analysis; for large libraries, this can be resource intensive. Here, we present streammd: a fast, memory-efficient, single-pass duplicate marker …
View article: Additional file 1 of The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study
Additional file 1 of The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study Open
Additional file 1: Table S1. Clinical information for all individuals recruited inclusive of index cases and family members. Table S2. Recorded risk-management strategies and related parameters. Table S3. Virtual gene panels used. Table S4…
View article: Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy
Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy Open
Data Tables are the Supplementary Data for the paper: Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy by Naeini et al.
View article: Virtual Cohort Assembly Discovery Phase Report: National Community Needs & Candidate Solutions
Virtual Cohort Assembly Discovery Phase Report: National Community Needs & Candidate Solutions Open
The Human Genomes Platform Project (HGPP) is a nationally-funded collaborative research project aiming to enhance capability for securely and responsibly sharing human genomics research data. National and international connectivity will ma…