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View article: Circulating plasma EBV DNA: a potential tool to facilitate diagnosis of pediatric Burkitt lymphoma in sub-Saharan Africa
Circulating plasma EBV DNA: a potential tool to facilitate diagnosis of pediatric Burkitt lymphoma in sub-Saharan Africa Open
View article: A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival
A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival Open
View article: Lung functions among children and adolescents with sickle cell disease receiving care at Jaramogi Oginga Odinga Teaching and Referral Hospital Kisumu, Kenya
Lung functions among children and adolescents with sickle cell disease receiving care at Jaramogi Oginga Odinga Teaching and Referral Hospital Kisumu, Kenya Open
Sickle cell disease is a genetic disorder associated with lifelong symptoms of anemia, vaso-oclusive crisis and organ damage. Pulmonary complications and declining lung functions are contributors to morbidity and mortality. Determination o…
View article: Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma
Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma Open
Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum . However, whether human leukocyte antigen ( HLA ) p…
View article: Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa Open
View article: Maternal age extremes and adverse pregnancy outcomes in low-resourced settings
Maternal age extremes and adverse pregnancy outcomes in low-resourced settings Open
Introduction Adolescent (<20 years) and advanced maternal age (>35 years) pregnancies carry adverse risks and warrant a critical review in low- and middle-income countries where the burden of adverse pregnancy outcomes is highest. Ob…
View article: Sickle cell allele <scp><i>HBB</i></scp>‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa
Sickle cell allele <span><i>HBB</i></span>‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa Open
Burkitt lymphoma (BL) is an aggressive B‐cell lymphoma that significantly contributes to childhood cancer burden in sub‐Saharan Africa. Plasmodium falciparum , which causes malaria, is geographically associated with BL, but the evidence re…
View article: Assessment of dietary intake of Vitamin A-rich foods and associated factors among lactating mothers attending Lunga Lunga Health Centre, in Sinai slum, Nairobi County, Kenya
Assessment of dietary intake of Vitamin A-rich foods and associated factors among lactating mothers attending Lunga Lunga Health Centre, in Sinai slum, Nairobi County, Kenya Open
Vitamin A deficiency is a problem of public health significance among lactating mothers. Low dietary intake of vitamin A results in inadequate vitamin A concentration in breastmilk, thereby putting the life of the breastfed child at risk. …
View article: <i>IFNL4</i> Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa
<i>IFNL4</i> Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa Open
Interferon lambda 4 (IFN-λ4) is a novel type-III interferon that can be expressed only by carriers of the genetic variant rs368234815-dG within the first exon of the IFNL4 gene. Genetic inability to produce IFN-λ4 (in carriers of th…
View article: GENOME‐WIDE ASSOCIATION STUDY OF CHILDHOOD BURKITT LYMPHOMA IN EAST AFRICA IDENTIFIES A NOVEL GERMLINE SUSCEPTIBILITY LOCUS ON CHROMOSOME 21
GENOME‐WIDE ASSOCIATION STUDY OF CHILDHOOD BURKITT LYMPHOMA IN EAST AFRICA IDENTIFIES A NOVEL GERMLINE SUSCEPTIBILITY LOCUS ON CHROMOSOME 21 Open
Introduction: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with hallmark somatic IG::MYC chromosomal translocations. BL is responsible for a significant proportion of childhood cancers in equatorial Africa, where exposure to Epst…
View article: Birth weight and gestational age distributions in a rural Kenyan population
Birth weight and gestational age distributions in a rural Kenyan population Open
View article: Burkitt lymphoma risk shows geographic and temporal associations with <i>Plasmodium falciparum</i> infections in Uganda, Tanzania, and Kenya
Burkitt lymphoma risk shows geographic and temporal associations with <i>Plasmodium falciparum</i> infections in Uganda, Tanzania, and Kenya Open
Endemic Burkitt lymphoma (eBL) is a pediatric cancer coendemic with malaria in sub-Saharan Africa, suggesting an etiological link between them. However, previous cross-sectional studies of limited geographic areas have not found a convinci…
View article: Birth weight and gestational age distributions in a rural Kenyan population
Birth weight and gestational age distributions in a rural Kenyan population Open
BackgroundWith the increased availability of access to prenatal ultrasound in low/middle-income countries, there is opportunity to better characterize the association between fetal growth and birth weight across global settings. This is im…
View article: Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome and LMP-1 Sequence Patterns: Analysis of Archival Datasets and Field Samples From Uganda, Tanzania, and Kenya
Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome and LMP-1 Sequence Patterns: Analysis of Archival Datasets and Field Samples From Uganda, Tanzania, and Kenya Open
Epstein-Barr virus (EBV) is associated with endemic Burkitt lymphoma (eBL), but the contribution of EBV variants is ill-defined. Studies of EBV whole genome sequences (WGS) have identified phylogroups that appear to be distinct for Asian v…
View article: Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study
Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study Open
View article: Why are the Pakistani maternal, fetal and newborn outcomes so poor compared to other low and middle-income countries?
Why are the Pakistani maternal, fetal and newborn outcomes so poor compared to other low and middle-income countries? Open
Background Pakistan has among the poorest pregnancy outcomes worldwide, significantly worse than many other low-resource countries. The reasons for these differences are not clear. In this study, we compared pregnancy outcomes in Pakistan …
View article: Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya
Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya Open
Background Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unknown. To address…
View article: Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya
Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya Open
Summary Platelet counts are decreased in Plasmodium falciparum malaria, which is aetiologically linked with endemic Burkitt lymphoma (eBL). However, the pattern of platelet counts in eBL cases is unknown. We studied platelet counts in 582 …
View article: Additional file 1 of Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya
Additional file 1 of Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya Open
Additional file 1: Table S1. A list of articles with used as sources for relevant data about malaria conditions in East Africa.
View article: Epstein barr virus IgG and EBER-1 in Burkitt’s lymphoma children at a referral hospital in western Kenya
Epstein barr virus IgG and EBER-1 in Burkitt’s lymphoma children at a referral hospital in western Kenya Open
Burkitt's lymphoma (BL) is a frequent childhood B cell non-Hodgkin's lymphoma (NHL) in equatorial Africa associated with infections. Chronic Epstein Barr virus (EBV) infections can lead to host immune stimulation that may trigger genetic t…
View article: Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya
Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya Open
Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan African countries, however, few epidemiologic studies have been undertaken and none attempted enrolling cases from multiple countries. We therefore conducted…
View article: Preventing birth of sicklers as an effective strategy in a sickle cell disease control programme
Preventing birth of sicklers as an effective strategy in a sickle cell disease control programme Open
View article: Newborn screening for sickle cell disease at Kisumu County Hospital, Kisumu –Kenya
Newborn screening for sickle cell disease at Kisumu County Hospital, Kisumu –Kenya Open
Background: Sickle cell disease(SCD), a hereditary blood disorder of the haemoglobin molecule, has been acknowledged by World Health Organization(WHO) as a major public health priority. Newborn screening(NBS) for SCD coupled with provision…
View article: The prevalence of Sickle Cell Trait among adolescents in Bungoma county, Kenya
The prevalence of Sickle Cell Trait among adolescents in Bungoma county, Kenya Open
Background information: Sickle cell disease (SCD) is a genetic disorder that affects the haemoglobin (Hb) molecule. Interventions for SCD needs to be supported by local data.Objective: To determine the prevalence of sickle cell trait (HbAS…
View article: A Cross-Sectional Population Study of Geographic, Age-Specific, and Household Risk Factors for Asymptomatic Plasmodium falciparum Malaria Infection in Western Kenya
A Cross-Sectional Population Study of Geographic, Age-Specific, and Household Risk Factors for Asymptomatic Plasmodium falciparum Malaria Infection in Western Kenya Open
The burden of Plasmodium falciparum ( Pf ) malaria in Kenya is decreasing; however, it is still one of the top 10 causes of morbidity, particularly in regions of western Kenya. Between April 2015 and June 2016, we enrolled 965 apparently h…
View article: Trends and determinants of stillbirth in developing countries: results from the Global Network’s Population-Based Birth Registry
Trends and determinants of stillbirth in developing countries: results from the Global Network’s Population-Based Birth Registry Open
View article: A prospective cause of death classification system for maternal deaths in low and middle‐income countries: results from the Global Network Maternal Newborn Health Registry
A prospective cause of death classification system for maternal deaths in low and middle‐income countries: results from the Global Network Maternal Newborn Health Registry Open
Objective To describe the causes of maternal death in a population‐based cohort in six low‐ and middle‐income countries using a standardised, hierarchical, algorithmic cause of death ( COD ) methodology. Design A population‐based, prospect…
View article: Cytokines associated with Burkitt’s lymphoma in western Kenya
Cytokines associated with Burkitt’s lymphoma in western Kenya Open
View article: Assessment of cold chain management practices in immunisation centres in Kacheliba division, Pokot County, Kenya
Assessment of cold chain management practices in immunisation centres in Kacheliba division, Pokot County, Kenya Open
Background: Immunisation contributes significantly to the achievement of MDGs. It is one of the eight elements and success stories of primary health care. Proper utilisation of Immunisation services is associated with improved child health…
View article: Global Network for Women's and Children's Health Research: probable causes of stillbirth in low‐ and middle‐income countries using a prospectively defined classification system
Global Network for Women's and Children's Health Research: probable causes of stillbirth in low‐ and middle‐income countries using a prospectively defined classification system Open
Objective We sought to classify causes of stillbirth for six low‐middle‐income countries using a prospectively defined algorithm. Design Prospective, observational study. Setting Communities in India, Pakistan, Guatemala, Democratic Republ…