Constantia Zeiser
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View article: High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas
High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas Open
View article: Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours
Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours Open
View article: LGG-16. NOVEL COMBINATION THERAPIES FOR PEDIATRIC LOW-GRADE GLIOMA AND CHARACTERIZATION OF THE UNDERLYING CELL DEATH MECHANISMS
LGG-16. NOVEL COMBINATION THERAPIES FOR PEDIATRIC LOW-GRADE GLIOMA AND CHARACTERIZATION OF THE UNDERLYING CELL DEATH MECHANISMS Open
BACKGROUND The majority of pediatric low-grade gliomas (pLGGs) harbor a MAPK/ERK pathway overactivating alteration, making them suitable for MAPK-targeted therapies such as MEK inhibition. However, MEK inhibitor treatment alone is in most …
View article: MODL-15. High-throughput combination drug screening identifies synergism between retinoic acid treatment and BCL-XL-inhibition in <i>MYC(N)</i>-driven medulloblastoma and neuroblastoma models
MODL-15. High-throughput combination drug screening identifies synergism between retinoic acid treatment and BCL-XL-inhibition in <i>MYC(N)</i>-driven medulloblastoma and neuroblastoma models Open
PURPOSE: Despite remarkable improvements in childhood cancer survival, certain high-risk entities including malignancies of the nervous system still carry dismal prognoses. Retinoic acid (RA) treatment has long been administered in high-ri…