Constantin R. Popescu
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View article: Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes
Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes Open
Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repe…
View article: DDIT4L regulates mitochondrial and innate immune activities in early life
DDIT4L regulates mitochondrial and innate immune activities in early life Open
Pattern recognition receptor responses are profoundly attenuated before the third trimester of gestation in the relatively low-oxygen human fetal environment. However, the mechanisms regulating these responses are uncharacterized. Herein, …
View article: World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study
World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study Open
Bacterial sepsis is generally a major concern in ill infants. To help triaging decisions by front-line health workers in these situations, the World Health Organization (WHO) has developed danger signs (DS). The objective of this study was…
View article: World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study
World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study Open
Bacterial sepsis is generally a major concern in ill infants. To help triaging decisions by front-line health workers in these situations, the World Health Organization (WHO) has developed danger signs (DS). The objective of this study was…
View article: Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda
Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda Open
BACKGROUND Reducing child mortality in low-income countries is constrained by a lack of vital statistics. In the absence of such data, verbal autopsies provide an acceptable method to determining attributable causes of death. The objective…
View article: World Health Organization Danger Signs to predict bacterial sepsis in newborns: A pragmatic prospective cohort study
World Health Organization Danger Signs to predict bacterial sepsis in newborns: A pragmatic prospective cohort study Open
Background The World Health Organization (WHO) has developed danger signs (DS) to help front-line health workers triage interventions in children with severe illnesses. Our objective was to evaluate the extent to which DS predict bacterial…
View article: Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol
Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol Open
Conducting collaborative and comprehensive epidemiological research on neonatal sepsis in low- and middle-income countries (LMICs) is challenging due to a lack of diagnostic tests. This prospective study protocol aims to obtain epidemiolog…
View article: Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in low-and middle-income countries: A study protocol
Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in low-and middle-income countries: A study protocol Open
Conducting collaborative and comprehensive epidemiological research on neonatal sepsis in low- and middle-income countries (LMICs) is challenging due to a lack of diagnostic tests. This prospective study protocol aims to obtain epidemiolog…
View article: 40 Respiratory syncytial virus-related outcomes from an abbreviated palivizumab dose regimen in children with congenital heart disease
40 Respiratory syncytial virus-related outcomes from an abbreviated palivizumab dose regimen in children with congenital heart disease Open
BACKGROUND: Respiratory Syncytial Virus (RSV) is a leading cause of hospital admission for acute lower respiratory tract infections (LRTI) in young children. Infants with congenital heart disease (CHD) are at a higher risk of severe infect…
View article: Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis
Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis Open
In infants with hemodynamically significant congenital heart disease, a 4-dose fixed-date palivizumab schedule over a 6-month season provided seasonal protection comparable to that in a clinical trial involving a standard 5-dose schedule. …
View article: Why haven't the documented benefits of probiotics on preterm babies led to their wider acceptance and use?
Why haven't the documented benefits of probiotics on preterm babies led to their wider acceptance and use? Open
Two of the most dreadful complications faced by clinicians who are involved in the medical care of premature infants are infections and necrotising enterocolitis (NEC), which entail high morbidity and carry a high risk of mortality. In Nor…