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View article: ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication
ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication Open
The establishment of a virus infection is the result of the pathogen's ability to replicate in a hostile environment generated by the host's immune system. Here, we found that ISG15 restricts Dengue and Zika viruses' replication through th…
View article: The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection
The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection Open
Sterile alpha motif and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) inhibits HIV-1 replication in nondividing cells by reducing the intracellular dNTP pool. SAMHD1 also suppresses NF-κB activation induced by inflammatory …
View article: Epitranscriptomic <i>N</i> <sup>6</sup> -Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells
Epitranscriptomic <i>N</i> <sup>6</sup> -Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells Open
Posttranscriptional modification of viral and cellular RNA by N 6 -methyladenosine (m 6 A) plays an important role in regulating the replication of many viruses and the cellular immune response to infection. We therefore sought to define t…
View article: Epitranscriptomic <i>N</i><sup>6</sup>-methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells
Epitranscriptomic <i>N</i><sup>6</sup>-methyladenosine profile of SARS-CoV-2-infected human lung epithelial cells Open
N 6 -methyladenosine (m 6 A) is a dynamic post-transcriptional RNA modification that plays an important role in determining transcript fate. Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused the global pandemi…
View article: N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages
N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages Open
N 6 -methyladenosine (m 6 A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions. RNA m 6 A modification is regulated by two groups of cellular proteins, writers and erasers that add or re…
View article: TRAF6 and TAK1 Contribute to SAMHD1-Mediated Negative Regulation of NF-κB Signaling
TRAF6 and TAK1 Contribute to SAMHD1-Mediated Negative Regulation of NF-κB Signaling Open
Cells respond to pathogen infection by activating a complex innate immune signaling pathway, which culminates in the activation of transcription factors and secretion of a family of functionally and genetically related cytokines. However, …
View article: TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-κB signaling
TRAF6 and TAK1 contribute to SAMHD1-mediated negative regulation of NF-κB signaling Open
Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) restricts HIV-1 replication by limiting the intracellular dNTP pool. SAMHD1 also suppresses the activation of NF-κB in response to viral infections and inflammatory stimuli. H…
View article: ISG15/USP18/STAT2 is a molecular hub regulating autocrine IFN I-mediated control of Dengue and Zika virus replication
ISG15/USP18/STAT2 is a molecular hub regulating autocrine IFN I-mediated control of Dengue and Zika virus replication Open
SUMMARY The establishment of a virus infection is the result of the pathogen’s ability to replicate in a hostile environment generated by the host’s immune system. Here, we found that ISG15 restricts Dengue and Zika viruses’ replication th…