Coralie Zangarelli
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View article: The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons
The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons Open
Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual generations. A polyploid transcriptionally …
View article: A developmental condensin I complex assists the <i>Paramecium</i> PiggyMac domesticated transposase during programmed DNA elimination
A developmental condensin I complex assists the <i>Paramecium</i> PiggyMac domesticated transposase during programmed DNA elimination Open
Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium , elimination of transposable elements and their relics requires the Pig…
View article: The linker region of a development-specific DNA polymerase X ensures efficient repair of programmed DNA double-strand breaks in <i>Paramecium tetraurelia</i>
The linker region of a development-specific DNA polymerase X ensures efficient repair of programmed DNA double-strand breaks in <i>Paramecium tetraurelia</i> Open
During the sexual cycle, programmed genome rearrangement in Paramecium tetraurelia involves the non-homologous end joining (NHEJ) DNA repair pathway to eliminate specific germinal internal eliminated sequences (IESs) from the newly develop…
View article: The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in <i>Paramecium</i>
The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in <i>Paramecium</i> Open
Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the development of the somatic nucleus. Twenty-five nucleotide scanRNAs (scnRNAs) are produced fro…
View article: A development-specific POLX essential for programmed genome rearrangement in<i>Paramecium tetraurelia</i>
A development-specific POLX essential for programmed genome rearrangement in<i>Paramecium tetraurelia</i> Open
During the sexual cycle, programmed genome rearrangement (PGR) in Paramecium tetraurelia involves the non-homologous end joining (NHEJ) DNA repair pathway to eliminate specific germinal Internal Eliminated Sequences (IESs) from the newly d…
View article: Uncoupling of programmed DNA cleavage and repair jeopardizes the assembly of the Paramecium somatic genome
Uncoupling of programmed DNA cleavage and repair jeopardizes the assembly of the Paramecium somatic genome Open
In the ciliate Paramecium, the precise excision of numerous Internal Eliminated Sequences (IESs) from the somatic genome is essential at each sexual cycle. DNA double strands breaks (DSBs) are introduced by the PiggyMac endonuclease, and r…
View article: Uncoupling of programmed DNA cleavage and repair jeopardizes the assembly of the Paramecium somatic genome
Uncoupling of programmed DNA cleavage and repair jeopardizes the assembly of the Paramecium somatic genome Open
In the ciliate Paramecium, the precise excision of numerous Internal Eliminated Sequences (IESs) from the somatic genome is essential at each sexual cycle. DNA double strands breaks (DSBs) are introduced by the PiggyMac endonuclease, and r…
View article: Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangement during the <i>Paramecium</i> sexual cycle
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangement during the <i>Paramecium</i> sexual cycle Open
Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia, two micronuclei (MIC) serving sexual reproduction coex…
View article: The nuclear PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in<i>Paramecium</i>
The nuclear PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in<i>Paramecium</i> Open
Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of target DNA segments, including transposable elements. At each sexual generation, the development of the macronucleus (MAC) requires m…
View article: Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the<i>Paramecium</i>sexual cycle
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the<i>Paramecium</i>sexual cycle Open
Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia , two micronuclei (MIC) serving sexual reproduction coe…
View article: Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the Paramecium sexual cycle
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the Paramecium sexual cycle Open
Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia, two micronuclei (MIC) serving sexual reproduction coex…
View article: Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the Paramecium sexual cycle
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the Paramecium sexual cycle Open
Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia, two micronuclei (MIC) serving sexual reproduction coex…
View article: Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the Paramecium sexual cycle
Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangements during the Paramecium sexual cycle Open
Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia, two micronuclei (MIC) serving sexual reproduction coex…
View article: Developmental timing of programmed DNA elimination in <i>Paramecium tetraurelia</i> recapitulates germline transposon evolutionary dynamics
Developmental timing of programmed DNA elimination in <i>Paramecium tetraurelia</i> recapitulates germline transposon evolutionary dynamics Open
With its nuclear dualism, the ciliate Paramecium constitutes a unique model to study how host genomes cope with transposable elements (TEs). P. tetraurelia harbors two germline micronuclei (MICs) and a polyploid somatic macronucleus (MAC) …
View article: Developmental timing of programmed DNA elimination in <i>Paramecium tetraurelia</i> recapitulates germline transposon evolutionary dynamics
Developmental timing of programmed DNA elimination in <i>Paramecium tetraurelia</i> recapitulates germline transposon evolutionary dynamics Open
With its nuclear dualism, the ciliate Paramecium constitutes an original model to study how host genomes cope with transposable elements (TEs). P. tetraurelia harbors two germline micronuclei (MIC) and a polyploid somatic macronucleus (MAC…
View article: Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics
Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics Open
With its nuclear dualism, the ciliate Paramecium constitutes an original model to study how host genomes cope with transposable elements (TEs). P. tetraurelia harbors two germline micronuclei (MIC) and a polyploid somatic macronucleus (MAC…
View article: Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics
Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics Open
With its nuclear dualism, the ciliate Paramecium constitutes an original model to study how host genomes cope with transposable elements (TEs). P. tetraurelia harbors two germline micronuclei (MIC) and a polyploid somatic macronucleus (MAC…
View article: Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics
Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics Open
With its nuclear dualism, the ciliate Paramecium constitutes an original model to study how host genomes cope with transposable elements (TEs). P. tetraurelia harbors two germline micronuclei (MIC) and a polyploid somatic macronucleus (MAC…