Corbin Black
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View article: Structure of the ciliary tip central pair reveals the unique role of the microtubule-seam binding protein SPEF1
Structure of the ciliary tip central pair reveals the unique role of the microtubule-seam binding protein SPEF1 Open
Motile cilia are unique organelles with the ability to autonomously move. Force generated by beating cilia propels cells and moves fluids. The ciliary skeleton is made of peripheral doublet microtubules and a central pair (CP) with a disti…
View article: Effect of α-tubulin acetylation on the doublet microtubule structure
Effect of α-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Previous literatures suggest that acetylated microtubules are more stable and …
View article: Author response: Effect of α-tubulin acetylation on the doublet microtubule structure
Author response: Effect of α-tubulin acetylation on the doublet microtubule structure Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Abstract Acetylation of α-tubulin at the lysine…
View article: Author Response: Effect of alpha-tubulin acetylation on the doublet microtubule structure
Author Response: Effect of alpha-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by ATAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Previous literatures suggest that acetylated microtubules are more stable and …
View article: Effect of alpha-tubulin acetylation on the doublet microtubule structure
Effect of alpha-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by ATAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Previous literatures suggest that acetylated microtubules are more stable and …
View article: Effect of α-tubulin acetylation on the doublet microtubule structure
Effect of α-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by αTAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Previous literatures suggest that acetylated microtubules are more stable and …
View article: Effect of alpha-tubulin acetylation on the doublet microtubule structure
Effect of alpha-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by ATAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Acetylated microtubules are more stable and damage resistant. αK40 acetylation…
View article: Joint Public Review: Effect of alpha-tubulin acetylation on the doublet microtubule structure
Joint Public Review: Effect of alpha-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by ATAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Acetylated microtubules are more stable and damage resistant. αK40 acetylation…
View article: Effect of alpha-tubulin acetylation on the doublet microtubule structure
Effect of alpha-tubulin acetylation on the doublet microtubule structure Open
Acetylation of α-tubulin at the lysine 40 residue (αK40) by ATAT1/MEC-17 acetyltransferase modulates microtubule properties and occurs in most eukaryotic cells. Acetylated microtubules are more stable and damage resistant. αK40 acetylation…
View article: Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism
Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism Open
Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacen…
View article: Reviewer #2 (Public Review): Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
Reviewer #2 (Public Review): Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia Open
Radial spokes (RS), the T-shaped, multiprotein complexes of motile cilia, transmit regulatory signals from the central apparatus to the outer doublet complexes, including inner dynein arms. In the vast majority of ciliated species, RSs ass…
View article: Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia Open
Radial spokes (RS), the T-shaped, multiprotein complexes of motile cilia, transmit regulatory signals from the central apparatus to the outer doublet complexes, including inner dynein arms. In the vast majority of ciliated species, RSs ass…
View article: Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia Open
Radial spokes (RS), the T-shaped, multiprotein complexes of motile cilia, transmit regulatory signals from the central apparatus to the outer doublet complexes, including inner dynein arms. In the vast majority of ciliated species, RSs ass…
View article: Author Response: Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia
Author Response: Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia Open
Radial spokes (RS), the T-shaped, multiprotein complexes of motile cilia, transmit regulatory signals from the central apparatus to the outer doublet complexes, including inner dynein arms. In the vast majority of ciliated species, RSs ass…
View article: CEP104/FAP256 and associated cap complex maintain stability of the ciliary tip
CEP104/FAP256 and associated cap complex maintain stability of the ciliary tip Open
Cilia are essential organelles that protrude from the cell body. Cilia are made of a microtubule-based structure called the axoneme. In most types of cilia, the ciliary tip is distinct from the rest of the cilium. Here, we used cryo-electr…
View article: Heterogeneity of radial spokes structural components and associated enzymes in <i>Tetrahymena</i> cilia
Heterogeneity of radial spokes structural components and associated enzymes in <i>Tetrahymena</i> cilia Open
Summary Radial spokes, RS1-RS2-RS3, are T-shaped, multiprotein complexes that transmit regulatory signals from central apparatus to outer doublet dyneins. RSs, especially RS3, differ in morphology, protein composition, and RS base-docked I…
View article: Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism
Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism Open
Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacen…
View article: Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes
Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes Open
Premessenger RNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein complex that assembles in a highly regulated process on each intronic substrate. Most studies of splicing and spliceosomes have been carried out in hu…
View article: Molecular architecture of the ciliary tip revealed by cryo-electron tomography
Molecular architecture of the ciliary tip revealed by cryo-electron tomography Open
Cilia are essential organelles that protrude from the cell body. Cilia are made of a microtubule-based structure called the axoneme. In most types of cilia, the ciliary tip is distinct from the rest of the cilium. Here, we used cryo-electr…
View article: Native doublet microtubules from<i>Tetrahymena thermophila</i>reveal the importance of outer junction proteins
Native doublet microtubules from<i>Tetrahymena thermophila</i>reveal the importance of outer junction proteins Open
Cilia are ubiquitous eukaryotic organelles responsible for cellular motility and sensory functions. The ciliary axoneme is a microtubule-based cytoskeleton consisting of two central singlets and nine outer doublet microtubules. Cryo-electr…
View article: Cryo-EM structure of the <i>Agrobacterium tumefaciens</i> T-pilus reveals the importance of positive charges in the lumen
Cryo-EM structure of the <i>Agrobacterium tumefaciens</i> T-pilus reveals the importance of positive charges in the lumen Open
Agrobacterium tumefaciens is a natural genetic engineer that transfers DNA into plants and this is the most frequently applied process for the generation of genetically modified plants. DNA transfer is mediated by a type IV secretion syste…
View article: The amyloid-β1–42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution
The amyloid-β1–42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution Open
We have previously developed a unique 8-amino acid Aβ42 oligomer-Interacting Peptide (AIP) as a novel anti-amyloid strategy for the treatment of Alzheimer's disease. Our lead candidate has successfully progressed from test tubes (i.e., in …
View article: Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer
Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer Open
HER2 receptor tyrosine kinase (encoded by the ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (HER2-positive breast cancers). Resistance to HER2-targeting therapies is partially due to the loss of HER2 express…
View article: Preparation of Doublet Microtubule Fraction for Single Particle Cryo-electron Microscopy
Preparation of Doublet Microtubule Fraction for Single Particle Cryo-electron Microscopy Open
Over the years, studying the ultrastructure of the eukaryotic cilia/flagella using electron microscopy (EM) has contributed significantly toward our understanding of ciliary function. Major complexes in the cilia, such as inner and outer d…