Corbin D. Jacobs
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View article: Resolving Clinically Indeterminate Findings During Anal Cancer Surveillance with TTMV-HPV DNA
Resolving Clinically Indeterminate Findings During Anal Cancer Surveillance with TTMV-HPV DNA Open
Background/Objectives: Surveillance for anal squamous cell carcinoma (ASCC) recurrence relies on clinical examination and imaging. Post-treatment edema, fibrosis, and inflammation can result in clinically indeterminate findings (CIFs) that…
View article: Evaluating Tumor Tissue Modified Viral (TTMV)-HPV DNA for the Early Detection of Anal Squamous Cell Carcinoma Recurrence
Evaluating Tumor Tissue Modified Viral (TTMV)-HPV DNA for the Early Detection of Anal Squamous Cell Carcinoma Recurrence Open
Background: The incidence and mortality of anal squamous cell carcinoma (ASCC) are rising, with greater than 80% of cases linked to human papillomavirus (HPV), primarily HPV16. Post-treatment surveillance can be challenging due to the limi…
View article: Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis
Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis Open
Purpose: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent …
View article: Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA
Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA Open
The radiologic appearance of locally advanced lung cancer may be linked to molecular changes of the disease during treatment, but characteristics of this phenomenon are poorly understood. Radiomics, liquid biopsy of cell-free DNA (cfDNA), …
View article: Synergy between early-incorporation immunotherapy and extracranial radiotherapy in metastatic non-small cell lung cancer
Synergy between early-incorporation immunotherapy and extracranial radiotherapy in metastatic non-small cell lung cancer Open
Utilization of RT + eIT in mNSCLC is increasing. SBRT + eIT was associated with improved OS on propensity-score matched analysis. There were no significant differences in OS based on RT + eIT sequencing or site irradiated. Whether these ob…
View article: Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features
Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features Open
Background Alveolar ridge squamous cell carcinoma (ARSCC) is poorly represented in randomized trials. Methods Adults in the National Cancer Database diagnosed with ARSCC between 2010 and 2014 who should be considered for postoperative radi…
View article: A Design Process for a 3D Printed Patient-Specific Applicator for HDR Brachytherapy of the Orbit
A Design Process for a 3D Printed Patient-Specific Applicator for HDR Brachytherapy of the Orbit Open
BACKGROUND: This report describes a process for designing a 3D printed patient-specific applicator for HDR brachytherapy of the orbit. CASE PRESENTATION: A 34-year-old man with recurrent melanoma of the orbit was referred for consideration…
View article: Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature
Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature Open
Although the review of our institutional experience is limited by small numbers, our analysis suggests that definitive chemoradiation therapy is the preferred treatment approach to rectal SCC based on improved disease-related outcomes, sph…
View article: Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers
Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers Open
Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was perf…
View article: 3D Printed Patient-Specific Applicator for HDR Brachytherapy of the Orbit
3D Printed Patient-Specific Applicator for HDR Brachytherapy of the Orbit Open
BACKGROUND This report describes a process for designing a 3D printed patient-specific applicator for HDR brachytherapy of the orbit. CASE PRESENTATION A 34-year-old man with recurrent melanoma of the orbit was referred for consideration o…
View article: RADI-06. SINGLE- VERSUS MULTI-FRACTION STEREOTACTIC RADIOSURGERY FOR BRAINSTEM METASTASES
RADI-06. SINGLE- VERSUS MULTI-FRACTION STEREOTACTIC RADIOSURGERY FOR BRAINSTEM METASTASES Open
BACKGROUND: For intracranial metastases with planning target volume (PTV) overlap of the brainstem (BSmet), the radiosurgical dose-fractionation that optimizes the therapeutic window is unknown. MATERIALS/METHODS: A retrospective review of…
View article: Hypofractionated Image-Guided Radiation Therapy With Simultaneous-Integrated Boost Technique for Limited Metastases: A Multi-Institutional Analysis
Hypofractionated Image-Guided Radiation Therapy With Simultaneous-Integrated Boost Technique for Limited Metastases: A Multi-Institutional Analysis Open
Purpose: To perform a multi-institutional analysis following treatment of limited osseous and/or nodal metastases in patients using a novel hypofractionated image-guided radiotherapy with simultaneous-integrated boost (HIGRT-SIB) technique…
View article: Dynamic Changes in Circulating Tumor DNA During Chemoradiation for Locally Advanced Lung Cancer
Dynamic Changes in Circulating Tumor DNA During Chemoradiation for Locally Advanced Lung Cancer Open
Dynamic changes in both cfDNA and ctDNA were observed throughout the course of CRT in patients with locally advanced lung cancer. Specific mutations with therapeutic implications can be identified and tracked using NGS methodologies. Furth…
View article: Pretreatment biopsy analysis of <scp>DAB</scp>2<scp>IP</scp> identifies subpopulation of high‐risk prostate cancer patients with worse survival following radiation therapy
Pretreatment biopsy analysis of <span>DAB</span>2<span>IP</span> identifies subpopulation of high‐risk prostate cancer patients with worse survival following radiation therapy Open
Decreased expression of tumor suppressor DAB 2 IP is linked to aggressive cancer and radiation resistance in several malignancies, but clinical survival data is largely unknown. We hypothesized that pretreatment DAB 2 IP reduction would pr…