Corey Chung
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View article: Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in <i>Saccharomyces cerevisiae</i>
Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in <i>Saccharomyces cerevisiae</i> Open
The lipid phosphatase Fig4 is conserved in all eukaryotes and is associated with human neurological diseases for which there are currently no specific therapies. Fig4 functions in both the production and turnover of its lipid substrate, PI…
View article: Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold
Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold Open
The lipid phosphatase Fig4 modulates the production and turnover of the signaling lipid PI3,5P2 through participation in a complex with its opposing kinase, Fab1, and the scaffold protein Vac14. Fig4 point mutations are associated with neu…
View article: Abstract 2455 Fig4 disease-related variants confer a Ste20-dependent growth advantage on rapamycin independent of Vac14
Abstract 2455 Fig4 disease-related variants confer a Ste20-dependent growth advantage on rapamycin independent of Vac14 Open
Fig4, a phosphoinositide (PI) lipid phosphatase, dephosphorylates the 5-position of the inositol ring of PI3,5P2, a low abundance and highly regulated signaling lipid. Mutations in Fig4 have been implicated in childhood-onset and developme…