Corey J. Ketchem
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View article: The Index of Severity for Eosinophilic Esophagitis Helps Predict Treatment Response to Dupilumab
The Index of Severity for Eosinophilic Esophagitis Helps Predict Treatment Response to Dupilumab Open
View article: Segmental overlap is common in eosinophilic gastrointestinal diseases and impacts clinical presentation and treatment
Segmental overlap is common in eosinophilic gastrointestinal diseases and impacts clinical presentation and treatment Open
Summary Little is known about the extent or importance of overlapping gastrointestinal (GI) tract involvement in eosinophilic gastrointestinal diseases (EGIDs), how presentations differ by areas of involvement, and whether overlap impacts …
View article: Potassium-Competitive Acid Blockers and Proton Pump Inhibitors: The Dynamic Duo of Acid Blockers.
Potassium-Competitive Acid Blockers and Proton Pump Inhibitors: The Dynamic Duo of Acid Blockers. Open
The management of acid-based disorders was transformed in the 1980s with the advent of proton pump inhibitors (PPIs), which target the hydrogen-potassium adenosine triphosphatase (proton pump) of the parietal cell. Potassium-competitive ac…
View article: Artificial Intelligence Chatbot Shows Multiple Inaccuracies When Responding to Questions About Eosinophilic Esophagitis
Artificial Intelligence Chatbot Shows Multiple Inaccuracies When Responding to Questions About Eosinophilic Esophagitis Open
View article: Clinical Features and Treatment Response to Topical Steroids in Ethnic and Racial Minority Patients With Eosinophilic Esophagitis
Clinical Features and Treatment Response to Topical Steroids in Ethnic and Racial Minority Patients With Eosinophilic Esophagitis Open
INTRODUCTION: Differences in eosinophilic esophagitis (EoE) presentation and outcomes by ethnicity or race remain understudied. We aimed to determine whether EoE patients of Hispanic/Latinx ethnicity or non-White race have differences in p…
View article: Eosinophilic esophagitis patients with multiple atopic conditions
Eosinophilic esophagitis patients with multiple atopic conditions Open
View article: Increasing Rates of Esophageal Stricture and Dilation Over 2 Decades in Eosinophilic Esophagitis
Increasing Rates of Esophageal Stricture and Dilation Over 2 Decades in Eosinophilic Esophagitis Open
Eosinophilic esophagitis (EoE) is a clinicopathologic condition that is characterized by chronic inflammation with variable manifestations.1 Esophageal strictures are one of the fibrotic remodeling features of EoE and are more commonly see…
View article: Higher Body Mass Index Is Associated With Decreased Treatment Response to Topical Steroids in Eosinophilic Esophagitis
Higher Body Mass Index Is Associated With Decreased Treatment Response to Topical Steroids in Eosinophilic Esophagitis Open
View article: Low Prevalence of Endoscopic Screening for Barrett's Esophagus in a Screening-Eligible Primary Care Population
Low Prevalence of Endoscopic Screening for Barrett's Esophagus in a Screening-Eligible Primary Care Population Open
INTRODUCTION: Despite societal recommendations supporting Barrett's esophagus (BE) screening, it is unknown what proportion of eligible patients is screened in primary care. We assessed the proportion of BE screening- eligible patients eva…
View article: Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response
Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response Open
Eosinophilic esophagitis (EoE) has been associated with autoimmune (AI) and connective tissue disorders (CTDs), but clinical correlates and treatment response to topical corticosteroids (tCS) for patients with both conditions are not well …
View article: Avoidant Restrictive Food Intake Disorder in Adults With Eosinophilic Esophagitis
Avoidant Restrictive Food Intake Disorder in Adults With Eosinophilic Esophagitis Open
View article: Older patients with eosinophilic esophagitis have high treatment response to topical steroids
Older patients with eosinophilic esophagitis have high treatment response to topical steroids Open
View article: A Gap in Care Leads to Progression of Fibrosis in Eosinophilic Esophagitis Patients
A Gap in Care Leads to Progression of Fibrosis in Eosinophilic Esophagitis Patients Open
View article: Psychiatric Comorbidities Are Highly Prevalent in Nonesophageal Eosinophilic Gastrointestinal Diseases
Psychiatric Comorbidities Are Highly Prevalent in Nonesophageal Eosinophilic Gastrointestinal Diseases Open
View article: Treatment with compounded fluticasone suspension improves the clinical, endoscopic, and histologic features of eosinophilic esophagitis
Treatment with compounded fluticasone suspension improves the clinical, endoscopic, and histologic features of eosinophilic esophagitis Open
Summary No approved medication exists for the treatment of eosinophilic esophagitis (EoE) in the United States, which forces patients to utilize off-label drugs and/or create their own formulations. We assessed the efficacy of a standardiz…
View article: Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging
Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging Open
View article: The Antiarrhythmic Drug, Amiodarone, Decreases AKT Activity and Sensitizes Human Acute Myeloid Leukemia Cells to Apoptosis by ABT-263
The Antiarrhythmic Drug, Amiodarone, Decreases AKT Activity and Sensitizes Human Acute Myeloid Leukemia Cells to Apoptosis by ABT-263 Open
Overall, our findings suggest that combining K+ channel blockers with prosurvival Bcl-2 family inhibitors is a promising therapeutic approach in treating leukemia.
View article: Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats
Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats Open
Dopamine decreases Na-K-ATPase (NKA) activity by PKC-dependent phosphorylation and endocytosis of the NKA α1. Dopamine-mediated regulation of NKA is impaired in aging and some forms of hypertension. Using opossum (OK) proximal tubule cells…
View article: Low dose ouabain stimulates Na K ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells
Low dose ouabain stimulates Na K ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells Open
View article: Role of Na<sup>+</sup>/H<sup>+</sup>exchanger regulatory factor 1 in forward trafficking of the type IIa Na<sup>+</sup>-P<sub>i</sub>cotransporter
Role of Na<sup>+</sup>/H<sup>+</sup>exchanger regulatory factor 1 in forward trafficking of the type IIa Na<sup>+</sup>-P<sub>i</sub>cotransporter Open
Na + /H + exchanger regulatory factor (NHERF1) plays a critical role in the renal transport of phosphate by binding to Na + -P i cotransporter (NpT2a) in the proximal tubule. While the association between NpT2a and NHERF1 in the apical mem…