Corey L. Bretz
YOU?
Author Swipe
View article: Trans-allelic mutational effects at the Peg3 imprinted locus
Trans-allelic mutational effects at the Peg3 imprinted locus Open
How one allele interacts with the other for the function of a gene is not well understood. In this study, we tested potential allelic interaction at the Peg3 imprinted locus with several mutant alleles targeting an Imprinting Control Regio…
View article: Allele and dosage specificity of the Peg3 imprinted domain
Allele and dosage specificity of the Peg3 imprinted domain Open
The biological impetus for gene dosage and allele specificity of mammalian imprinted genes is not fully understood. To address this, we generated and analyzed four sets of mice from a single breeding scheme with varying allelic expression …
View article: Transcription-driven DNA methylation setting on the mouse <i>Peg3</i> locus
Transcription-driven DNA methylation setting on the mouse <i>Peg3</i> locus Open
The imprinting of the mouse Peg3 domain is controlled through the Peg3-DMR, which obtains its maternal-specific DNA methylation during oogenesis. In the current study, we deleted an oocyte-specific alternative promoter, termed U1, which is…
View article: Epigenetic response of imprinted domains during carcinogenesis
Epigenetic response of imprinted domains during carcinogenesis Open
Overall, this study demonstrates that imprinted domains are targeted for DNA hypermethylation when benign tumor cells transition to malignant. Thus, monitoring DNA methylation within imprinted domains may be useful in evaluating the progre…
View article: Transcription-driven DNA methylation setting on the mouse <i>Peg3</i> locus
Transcription-driven DNA methylation setting on the mouse <i>Peg3</i> locus Open
The imprinting of the mouse Peg3 domain is controlled through the Peg3-DMR, which obtains its maternal-specific DNA methylation during oogenesis. In the current study, we deleted an oocyte-specific alternative promoter, termed U1, which is…