Corey Nislow
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View article: Correction: Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission
Correction: Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission Open
View article: A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept
A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept Open
Genetic interactions are typically studied by looking at the phenotype that results from disruption of pairs of genes, as well as from higher order combinations of perturbations. Systematically interrogating all pairwise combinations provi…
View article: Barcode sequencing: a robust, platform-agnostic method for massively parallel cell-based screens
Barcode sequencing: a robust, platform-agnostic method for massively parallel cell-based screens Open
Barcode sequencing (Bar-seq) is a high-throughput method originally developed for systematically identifying gene–drug interactions and genetic dependencies in yeast using pooled deletion-mutant libraries. This approach enables high-resolu…
View article: Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission
Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission Open
View article: CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity
CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity Open
Cancer therapy is limited by resistance to standard-of-care chemotherapeutic and/or by treatment-associated toxicity. Identifying molecular mechanisms that modulate cellular toxicity is crucial for enhancing treatment efficacy. We characte…
View article: Mining yeast diversity unveils novel targets for improved heterologous laccase production in Saccharomyces cerevisiae
Mining yeast diversity unveils novel targets for improved heterologous laccase production in Saccharomyces cerevisiae Open
View article: Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission
Programmed cell death and redox metabolism protect Chlamydomonas reinhardtii populations from the galactic cosmic environment on the Artemis-1 mission Open
We hypothesized that on the Artemis I mission, exposure to the galactic cosmic environment, specifically microgravity, lack of convection, and galactic cosmic radiation, would reduce survival of Chlamydomonas reinhardtii, a green unicellul…
View article: Mining Yeast Diversity Unveils Novel Targets for Improved Heterologous Laccase Production in<i>Saccharomyces cerevisiae</i>
Mining Yeast Diversity Unveils Novel Targets for Improved Heterologous Laccase Production in<i>Saccharomyces cerevisiae</i> Open
The budding yeast Saccharomyces cerevisiae is a widely utilized host cell for recombinant protein production due to its well studied and annotated genome, its ability to secrete large and post-translationally modified proteins, fast growth…
View article: The Addis Ababa Lions: Whole-Genome Sequencing of a Rare and Precious Population
The Addis Ababa Lions: Whole-Genome Sequencing of a Rare and Precious Population Open
Lions are widely known as charismatic predators that once roamed across the globe, but their populations have been greatly affected by environmental factors and human activities over the last 150 yr. Of particular interest is the Addis Aba…
View article: Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae
Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae Open
The yeast Saccharomyces cerevisiae is widely used as a host cell for recombinant protein production due to its fast growth, cost-effective culturing, and ability to secrete large and complex proteins. However, one major drawback is the rel…
View article: From beer to breadboards: yeast as a force for biological innovation
From beer to breadboards: yeast as a force for biological innovation Open
View article: Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins
Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins Open
In Saccharomyces cerevisiae, newly synthesized histones H3 are acetylated on lysine 56 (H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind replication forks. Two deacetylases of the sirtuin fam…
View article: Genome-wide screen identifies new set of genes for improved heterologous laccase expression in<i>Saccharomyces cerevisiae</i>
Genome-wide screen identifies new set of genes for improved heterologous laccase expression in<i>Saccharomyces cerevisiae</i> Open
The yeast Saccharomyces cerevisiae is widely used as a host cell for recombinant protein production due to its fast growth, cost-effective culturing, and ability to secrete large and complex proteins. However, one major drawback is the rel…
View article: Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling
Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling Open
View article: Characterization of the Lower Airways and Oral Microbiota in Healthy Young Persons in the Community
Characterization of the Lower Airways and Oral Microbiota in Healthy Young Persons in the Community Open
Lower airway dysbiosis contributes to disease pathogenesis in respiratory diseases. However, little is known regarding the microbiota of lower airways or the oral cavity of healthy young persons. To address this gap, 25 healthy persons (24…
View article: Additional file 2 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling
Additional file 2 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling Open
Additional file 2. Containing DIABLO results by COPD status.
View article: Additional file 4 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling
Additional file 4 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling Open
Additional file 4. Containing DIABLO results by COPD and HIV status.
View article: Additional file 3 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling
Additional file 3 of Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling Open
Additional file 3. Containing DIABLO results by HIV status.
View article: Experiment verification test of the Artemis I ‘Deep Space Radiation Genomics’ experiment
Experiment verification test of the Artemis I ‘Deep Space Radiation Genomics’ experiment Open
When the Artemis missions launch, NASA's Orion spacecraft (and crew as of the Artemis II mission) will be exposed to the deep space radiation environment beyond the protection of Earth's magnetosphere. Hence, it is essential to characteriz…
View article: Persistent acetylation of histone H3 lysine 56 compromises the activity of DNA replication origins
Persistent acetylation of histone H3 lysine 56 compromises the activity of DNA replication origins Open
In Saccharomyces cerevisiae , newly synthesized histone H3 are acetylated on lysine 56 (H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind replication forks. Two deacetylases of the sirtuin family, Hs…
View article: The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures Open
View article: Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance Open
View article: Additional file 5 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
Additional file 5 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures Open
Additional file 5: Table S1. GO enrichment analysis of cofit genes corresponding to Table 3.
View article: Additional file 6 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
Additional file 6 of The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures Open
Additional file 6: Table S2. Overlap coeffiecients for HIPLAB ➔ NIBR gene response signatures and NIBR ➔ HIPLAB gene response signatures and GO enrichments for all HIPLAB and NIBR gene response signatures.
View article: Correction to: Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury
Correction to: Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury Open
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View article: Author Correction: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells
Author Correction: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells Open
View article: Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury
Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury Open
View article: Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells
Cell spinpods are a simple inexpensive suspension culture device to deliver fluid shear stress to renal proximal tubular cells Open
View article: Seven Years at High Salinity—Experimental Evolution of the Extremely Halotolerant Black Yeast Hortaea werneckii
Seven Years at High Salinity—Experimental Evolution of the Extremely Halotolerant Black Yeast Hortaea werneckii Open
The experimental evolution of microorganisms exposed to extreme conditions can provide insight into cellular adaptation to stress. Typically, stress-sensitive species are exposed to stress over many generations and then examined for improv…
View article: The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures Open
BackgroundChemogenomic profiling is a powerful approach towards understanding the genome-wide cellular response to small molecules. Developed in Saccharomyces cerevisiae , chemogenomic screens provide direct, unbiased identification of dru…