Corey S. O’Hern
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View article: Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion
Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion Open
Breast cancer cells invade mammary adipose tissue during initial stages of metastasis but how the physical properties of adipose tissue regulate this process remains unclear. Here, we combined single cell mechanical characterization of pri…
View article: Particle-scale origin of quadrupolar nonaffine displacement fields in granular solids
Particle-scale origin of quadrupolar nonaffine displacement fields in granular solids Open
In this work, we identify the local structural defects that control the non-affine displacement fields in jammed disk packings subjected to athermal, quasistatic (AQS) simple shear. While complex non-affine displacement fields typically oc…
View article: A cadherin-integrin–ECM code for presomitic mesoderm fluidity
A cadherin-integrin–ECM code for presomitic mesoderm fluidity Open
Animal tissues exist within a continuum of fluid to solid states, and transitions between states are important for embryonic development, wound healing and cancer metastasis. Fluid-to-solid transitions are governed by the ratio of adhesive…
View article: Applying physical principles to cancer research
Applying physical principles to cancer research Open
View article: Anisotropic stress history effects in erodible sediment beds
Anisotropic stress history effects in erodible sediment beds Open
View article: Protein Folding as a Jamming Transition
Protein Folding as a Jamming Transition Open
Proteins fold to a specific functional conformation with a densely packed core that controls their stability. Despite their importance, we lack a quantitative explanation for why all protein cores, regardless of their overall fold, possess…
View article: Tuning the Size and Stiffness of Inflatable Particles
Tuning the Size and Stiffness of Inflatable Particles Open
We describe size-varying cylindrical particles made from silicone elastomers that can serve as building blocks for robotic granular materials. The particle size variation, which is achieved by inflation, gives rise to changes in stiffness …
View article: The effect of stereochemical constraints on the structural properties of folded proteins
The effect of stereochemical constraints on the structural properties of folded proteins Open
Proteins are composed of chains of amino acids that fold into complex three-dimensional structures. Several key features, such as the radius of gyration, fraction of core amino acids $f_{\rm core}$, packing fraction $\langle ϕ\rangle$ of c…
View article: Tuning the size and stiffness of inflatable particles
Tuning the size and stiffness of inflatable particles Open
We create inflatable particles that can stiffen or soften during inflation utilizing strain localization.
View article: Evolution of adaptive force chains in reconfigurable granular metamaterials
Evolution of adaptive force chains in reconfigurable granular metamaterials Open
We combine discrete element method simulations, evolutionary algorithms, and experiments to search for granular packings of variable modulus (VM) particles arranged in a triangular lattice with optimal bulk mechanical properties.
View article: Data-driven Modeling of Granular Chains with Modern Koopman Theory
Data-driven Modeling of Granular Chains with Modern Koopman Theory Open
Externally driven dense packings of particles can exhibit nonlinear wave phenomena that are not described by effective medium theory or linearized approximate models. Such nontrivial wave responses can be exploited to design sound-focusing…
View article: ProtSCAPE: Mapping the landscape of protein conformations in molecular dynamics
ProtSCAPE: Mapping the landscape of protein conformations in molecular dynamics Open
Understanding the dynamic nature of protein structures is essential for comprehending their biological functions. While significant progress has been made in predicting static folded structures, modeling protein motions on microsecond to m…
View article: Identifying the minimal sets of distance restraints for FRET-assisted protein structural modeling.
Identifying the minimal sets of distance restraints for FRET-assisted protein structural modeling. Open
Proteins naturally occur in crowded cellular environments and interact with other proteins, nucleic acids, and organelles. Since most previous experimental protein structure determination techniques require that proteins occur in idealized…
View article: Identifying topologically associating domains using differential kernels
Identifying topologically associating domains using differential kernels Open
Chromatin is a polymer complex of DNA and proteins that regulates gene expression. The three-dimensional (3D) structure and organization of chromatin controls DNA transcription and replication. High-throughput chromatin conformation captur…
View article: Computational modeling of the physical features that influence breast cancer invasion into adipose tissue
Computational modeling of the physical features that influence breast cancer invasion into adipose tissue Open
Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on both biochemical signaling and the mechanical properties of cancer cells, …
View article: Flow and clogging of capillary droplets
Flow and clogging of capillary droplets Open
Capillary droplets form due to surface tension when two immiscible fluids are mixed. We describe the motion of gravity-driven capillary droplets flowing through narrow constrictions and obstacle arrays in both simulations and experiments. …
View article: Gradient-based Design of Computational Granular Crystals
Gradient-based Design of Computational Granular Crystals Open
There is growing interest in engineering unconventional computing devices that leverage the intrinsic dynamics of physical substrates to perform fast and energy-efficient computations. Granular metamaterials are one such substrate that has…
View article: How <i>P. aeruginosa</i> cells with diverse stator composition collectively swarm
How <i>P. aeruginosa</i> cells with diverse stator composition collectively swarm Open
Swarming is a macroscopic phenomenon in which surface bacteria organize into a motile population. The flagellar motor that drives swarming in Pseudomonas aeruginosa is powered by stators MotAB and MotCD. Deletion of the MotCD stator elimin…
View article: Mechanical plasticity of cell membranes enhances epithelial wound closure
Mechanical plasticity of cell membranes enhances epithelial wound closure Open
During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like . We develop deformable particle (DP) model simulations to unders…
View article: Modeling the Effects of Varying the Ti Concentration on the Mechanical Properties of Cu–Ti Alloys
Modeling the Effects of Varying the Ti Concentration on the Mechanical Properties of Cu–Ti Alloys Open
The mechanical properties of CuTi alloys have been characterized extensively through experimental studies. However, a detailed understanding of why the strength of Cu increases after a small fraction of Ti atoms are added to the alloy is s…
View article: Correction: Flow and clogging of capillary droplets
Correction: Flow and clogging of capillary droplets Open
Correction for ‘Flow and clogging of capillary droplets’ by Yuxuan Cheng et al. , Soft Matter , 2024, https://doi.org/10.1039/D4SM00752B.
View article: Identifying topologically associating domains using differential kernels
Identifying topologically associating domains using differential kernels Open
Chromatin is a polymer complex of DNA and proteins that regulates gene expression. The three-dimensional structure and organization of chromatin controls DNA transcription and replication. High-throughput chromatin conformation capture tec…
View article: Effective subgrouping enhances machine learning prediction in complex materials science phenomena: Inoue's subgrouping in discovering bulk metallic glasses
Effective subgrouping enhances machine learning prediction in complex materials science phenomena: Inoue's subgrouping in discovering bulk metallic glasses Open
Addressing complex materials science problems through machine learning (ML) is challenging. A primary reason for the challenge is that the underlying controlling mechanisms may vary within the considered problem space. To quantify this, we…
View article: Modeling the effects of varying Ti concentration on the mechanical properties of Cu-Ti alloys
Modeling the effects of varying Ti concentration on the mechanical properties of Cu-Ti alloys Open
The mechanical properties of Cu-Ti alloys have been characterized extensively through experimental studies. However, a detailed understanding of why the strength of Cu increases after a small fraction of Ti atoms is added to the alloy is s…
View article: The connection between polymer collapse and the onset of jamming
The connection between polymer collapse and the onset of jamming Open
Previous studies have shown that the interiors of proteins are densely packed, reaching packing fractions that are as large as those found for static packings of individual amino-acid-shaped particles. How can the interiors of proteins tak…
View article: Universal Mechanical Polycomputation in Granular Matter
Universal Mechanical Polycomputation in Granular Matter Open
Unconventional computing devices are increasingly of interest as they can operate in environments hostile to silicon-based electronics, or compute in ways that traditional electronics cannot. Mechanical computers, wherein information proce…
View article: Corrigendum to 'Machine learning versus human learning in predicting glass-forming ability of metallic glasses' Acta Materialia 243 (2023) 118497
Corrigendum to 'Machine learning versus human learning in predicting glass-forming ability of metallic glasses' Acta Materialia 243 (2023) 118497 Open
View article: Mechanical Plasticity of Cell Membranes Enhances Epithelial Wound Closure
Mechanical Plasticity of Cell Membranes Enhances Epithelial Wound Closure Open
During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like \textit{Drosophila}. We develop deformable particle (DP) model si…
View article: How individual<i>P. aeruginosa</i>cells with diverse stator distributions collectively form a heterogeneous macroscopic swarming population
How individual<i>P. aeruginosa</i>cells with diverse stator distributions collectively form a heterogeneous macroscopic swarming population Open
Swarming is a macroscopic phenomenon in which surface bacteria organize into a motile population. The flagellar motor that drives swarming in Pseudomonas aeruginosa is powered by stators MotAB and MotCD. Deletion of the MotCD stator elimin…
View article: Tessellated granular metamaterials with tunable elastic moduli
Tessellated granular metamaterials with tunable elastic moduli Open
Most granular packings possess shear moduli ($G$) that increase with the applied external pressure, and bulk moduli ($B$) that increase or remain constant with pressure. This paper presents "tessellated" granular metamaterials for which bo…