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View article: Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism
Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism Open
Background Metastatic colorectal cancer (mCRC) is associated with high recurrence rates and resistance to conventional treatments, largely driven by cancer stem cells (CSCs) that contribute to tumor progression and therapeutic evasion. Thi…
View article: A new protocolized treatment strategy optimizing medical and surgical care leads to improved healing of Crohn’s perianal fistulas
A new protocolized treatment strategy optimizing medical and surgical care leads to improved healing of Crohn’s perianal fistulas Open
Background and Aims Crohn’s perianal fistula healing rates remain low. We evaluated the efficacy of a protocolized multidisciplinary treatment strategy optimizing care in adults with Crohn’s perianal fistulas. Methods A new treatment strat…
View article: Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB)
Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB) Open
Background The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn’s disease (CD) in patients with perianal fistula(s) (PAF). Methods A panel of international experts in the fie…
View article: P0260 Scoring indices grading radiologic disease activity severity on magnetic resonance imaging strongly reflect clinical healing of Crohn’s perianal fistulas
P0260 Scoring indices grading radiologic disease activity severity on magnetic resonance imaging strongly reflect clinical healing of Crohn’s perianal fistulas Open
Background Magnetic resonance imaging (MRI) is the gold-standard for evaluating Crohn’s perianal fistulas. Multiple scoring indices to grade radiologic disease activity severity have been established, with limited comparative data and a la…
View article: Low‐grade mucinous neoplasm arising from a recurrent mature sacrococcygeal teratoma
Low‐grade mucinous neoplasm arising from a recurrent mature sacrococcygeal teratoma Open
Extragonadal germ cell tumours (GCTs) arises outside the testes or ovaries and can occur in retroperitoneum, mediastinum and sacrococcygeal area.1, 2 Sacrococcygeal teratomas (SCTs) are most common in the paediatric population and account …
View article: Prophylactic negative pressure wound therapy to improve wound healing rates following ileostomy closure: a randomized controlled trial
Prophylactic negative pressure wound therapy to improve wound healing rates following ileostomy closure: a randomized controlled trial Open
Background Reversal of ileostomy is associated with morbidity including wound infection and prolonged wound healing. Negative pressure wound therapy (NPWT) has been shown to reduce time to wound healing by secondary intention. The aim of t…
View article: The empty pelvis syndrome: a core data set from the PelvEx collaborative
The empty pelvis syndrome: a core data set from the PelvEx collaborative Open
Background Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but is undefined. EPS outcome reporting and descriptors of radicality of PE are inconsistent; therefore, the best approaches fo…
View article: P934 A delphi consensus on the optimisation of medical and surgical therapy in perianal fistulising Crohn’s disease, targeted at individual TOpCLASS classification groups
P934 A delphi consensus on the optimisation of medical and surgical therapy in perianal fistulising Crohn’s disease, targeted at individual TOpCLASS classification groups Open
Background Perianal fistulising Crohn’s Disease (PFCD) is a challenging phenotype of IBD associated with poor outcomes. Classically, fistulae have been classified anatomically and guidelines have been generalised, with a lack of appreciati…
View article: DOP04 Screening and management of fistula cancers in patients with perianal fistulising Crohn’s Disease: an expert consensus
DOP04 Screening and management of fistula cancers in patients with perianal fistulising Crohn’s Disease: an expert consensus Open
Background Fistula cancer is a rare and often devastating diagnosis in patients with perianal fistulising Crohn’s disease (CD). Fistula cancer management is a complex process requiring multi-disciplinary effort. However, given the low inci…
View article: P547 Improved clinical and radiologic healing of Crohn’s perianal fistulas using a novel coordinated care model optimising medical and surgical treatments: A prospective real-world observational study
P547 Improved clinical and radiologic healing of Crohn’s perianal fistulas using a novel coordinated care model optimising medical and surgical treatments: A prospective real-world observational study Open
Background Despite best standard care, sustained healing rates of Crohn’s perianal fistulas remain low. A novel coordinated multi-disciplinary care model optimising medical and surgical treatment was established with the aim to improve fis…
View article: Empty pelvis syndrome: PelvEx Collaborative guideline proposal
Empty pelvis syndrome: PelvEx Collaborative guideline proposal Open
Contains fulltext : 302520.pdf (Publisher’s version ) (Open Access)
View article: Idiopathic myointimal hyperplasia: An unusual cause of colonic ischemia
Idiopathic myointimal hyperplasia: An unusual cause of colonic ischemia Open
Introduction: Ischemic colitis is a commonly encountered surgical condition with a variety of causes, including atrial fibrillation, atherosclerosis, hypoperfusion, vasculitis, and rarely drug causes such as methamphetamines. Case Report: …
View article: Supplementary Tables S4-S10 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Tables S4-S10 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
An excel file with several sheets, representing supp. tables S4-S10 in the paper.
View article: Supplementary Tables S2 and S3 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Tables S2 and S3 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
Table S2 is the list of studies identifying genes associated with Exh/Res programs. Table S3 is a list of signatures used for scoring tumour data and performing survival analysis
View article: Supplementary Tables S2 and S3 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Tables S2 and S3 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
Table S2 is the list of studies identifying genes associated with Exh/Res programs. Table S3 is a list of signatures used for scoring tumour data and performing survival analysis
View article: Supplementary Figures from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Figures from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
Supplementary data containing 25 Supp. figures that support the results of the paper.
View article: Supplementary Tables S4-S10 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Tables S4-S10 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
An excel file with several sheets, representing supp. tables S4-S10 in the paper.
View article: Data from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Data from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
Immunotherapy success in colorectal cancer is mainly limited to patients whose tumors exhibit high microsatellite instability (MSI). However, there is variability in treatment outcomes within this group, which is in part driven by the freq…
View article: Data from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Data from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
Immunotherapy success in colorectal cancer is mainly limited to patients whose tumors exhibit high microsatellite instability (MSI). However, there is variability in treatment outcomes within this group, which is in part driven by the freq…
View article: Supplementary Table S1 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Table S1 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
List of the tools and packages used in the manuscript
View article: Supplementary Figures from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Figures from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
Supplementary data containing 25 Supp. figures that support the results of the paper.
View article: Supplementary Table S1 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Supplementary Table S1 from The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome Open
List of the tools and packages used in the manuscript
View article: Supplemental Table S1 from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells
Supplemental Table S1 from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells Open
This table contains the sequence of all primers used for qPCR, of siren and shRNAs against claudin-2, as well as details about miRNA mimics and inhibitors used in this work.
View article: Supplemental Table S5 from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells
Supplemental Table S5 from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells Open
This table contains identified self-renewal target genes for the three candidate miRNA experimentally tested in our study, along with their prediction score. Only those targets with prediction score >0.85 are included.