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View article: Evolving Practices in Prenatal Open Spinal Dysraphism: A Global Survey of Selection Criteria, Surgical Techniques, and Diagnostic Trends
Evolving Practices in Prenatal Open Spinal Dysraphism: A Global Survey of Selection Criteria, Surgical Techniques, and Diagnostic Trends Open
Objective To provide an updated overview of international clinical practice in prenatal repair of open spinal dysraphism (OSD), focusing on evolving eligibility criteria, surgical techniques, and diagnostic standards. Methods A structured …
View article: Blood Pressure Optimization During Fetoscopic Repair of Open Spinal Dysraphism: Insights from Advanced Hemodynamic Monitoring
Blood Pressure Optimization During Fetoscopic Repair of Open Spinal Dysraphism: Insights from Advanced Hemodynamic Monitoring Open
Background/Objectives: Fetoscopic repair of open spinal dysraphism (OSD) is a rare intrauterine procedure performed in specialized fetal surgery centers. Conducted under restrictive fluid management and continuous tocolysis, it poses subst…
View article: Feasibility of continuous high-resolution bioreactance monitoring during cesarean delivery under spinal anesthesia
Feasibility of continuous high-resolution bioreactance monitoring during cesarean delivery under spinal anesthesia Open
Purpose This study is the first to apply bioreactance-based hemodynamic monitoring with a 4-s interval during cesarean delivery under spinal anesthesia. We evaluated the feasibility of continuous, high-resolution perioperative monitoring i…
View article: Influence of SARS-CoV-2 variants on stillbirth rate - data from the CRONOS registry
Influence of SARS-CoV-2 variants on stillbirth rate - data from the CRONOS registry Open
The CRONOS data confirm a virus-type-dependent effect of the Alpha and Delta variants on the placenta with a possible causal effect on stillbirth. In the context of an infection, targeted fetal monitoring appears appropriate. A stillbirth …
View article: Effects of in utero Open Spina Bifida Repair Using a Laparotomy-Assisted Fetoscopic Approach on the Fetal Cardiovascular System
Effects of in utero Open Spina Bifida Repair Using a Laparotomy-Assisted Fetoscopic Approach on the Fetal Cardiovascular System Open
Introduction: Various treatment options for the prenatal open spina bifida (OSB) repair have evolved over the past decades, including the laparotomy-assisted fetoscopic repair. However, little is known about the fetal vascular regulation d…
View article: Open Spinal Dysraphism Without Hindbrain Herniation—Natural History and Postnatal Outcome
Open Spinal Dysraphism Without Hindbrain Herniation—Natural History and Postnatal Outcome Open
Objective To report the natural history of fetuses with open spinal dysraphism (OSD) without hindbrain herniation (HBH) during second‐trimester evaluation. Methods A multicenter retrospective cohort study was conducted across three prenata…
View article: Peripartum heart failure in Finland: A population‐based record linkage study
Peripartum heart failure in Finland: A population‐based record linkage study Open
Aims Heart failure in late pregnancy and the postpartum period (HFPP) is a rare but potentially life‐threatening condition, with peripartum cardiomyopathy (PPCM) being the most common subtype. This study aims to comprehensively investigate…
View article: Prenatal Diagnosis of Fryns Syndrome through Identification of Two Novel Splice Variants in the PIGN Gene—A Case Series
Prenatal Diagnosis of Fryns Syndrome through Identification of Two Novel Splice Variants in the PIGN Gene—A Case Series Open
Fryns syndrome (FS) is a multiple congenital anomaly syndrome with different multisystemic malformations. These include congenital diaphragmatic hernia, pulmonary hypoplasia, and craniofacial dysmorphic features in combination with malform…
View article: Monitoring of Women with Anti-Ro/SSA and Anti-La/SSB Antibodies in Germany—Status Quo and Intensified Monitoring Concepts
Monitoring of Women with Anti-Ro/SSA and Anti-La/SSB Antibodies in Germany—Status Quo and Intensified Monitoring Concepts Open
Background: The fetuses of pregnant women affected by anti-Ro/anti-La antibodies are at risk of developing complete atrioventricular heart block (CAVB) and other potentially life-threatening cardiac affections. CAVB can develop in less tha…
View article: Initial experience with the anaesthetic management of fetoscopic spina bifida repair at a German University Hospital
Initial experience with the anaesthetic management of fetoscopic spina bifida repair at a German University Hospital Open
Spina bifida aperta (SBA) is a serious neural tube defect that can lead to a range of disabilities and health complications in affected individuals. In recent years, fetoscopic surgical repair has emerged as a promising new approach to tre…
View article: Monitoring of Women with Anti-ro/La Antibodies in Germany – Status Quo and Intensified Monitoring Concepts
Monitoring of Women with Anti-ro/La Antibodies in Germany – Status Quo and Intensified Monitoring Concepts Open
Fetuses of pregnant women affected by anti-Ro/anti La antibodies are at risk to develop complete atrioventricular heart block (CAVB) and other potentially life-threatening cardiac affections. CAVB can develop in less than 24 hours. Treatme…
View article: Implementation and Assessment of a Laparotomy-Assisted Three-Port Fetoscopic Spina Bifida Repair Program
Implementation and Assessment of a Laparotomy-Assisted Three-Port Fetoscopic Spina Bifida Repair Program Open
Open spina bifida (OSB) is a congenital, non-lethal malformation with multifactorial etiology. Fetal therapy can be offered under certain conditions to parents after accurate prenatal diagnostic and interdisciplinary counseling. Since the …
View article: Resilience of Gynecological and Obstetric Inpatient Care in Central Germany in Times of Repetitive Socioeconomic Shocks—An Epidemiological Study Assessing Standardized Health Services Indicators and Economic Status According to the aG-DRG Catalog
Resilience of Gynecological and Obstetric Inpatient Care in Central Germany in Times of Repetitive Socioeconomic Shocks—An Epidemiological Study Assessing Standardized Health Services Indicators and Economic Status According to the aG-DRG Catalog Open
Sequential socioeconomic shocks, including the COVID-19 pandemic, economic recession, or energy and refugee crises in the face of violent conflicts, have led to the failure of healthcare systems in Europe. Against this background, the aim …
View article: Hypertension in Pregnancy
Hypertension in Pregnancy Open
Cardiovascular diseases in pregnancy are increasing, and account for the majority of pregnancyinduced maternal deaths.Among them, hypertensive disorders are the most frequent, affecting 6-8% of all pregnancies.More severe forms, like preec…
View article: The Value of Delta Middle Cerebral Artery Peak Systolic Velocity for the Prediction of Twin Anemia-Polycythemia Sequence—Analysis of a Heterogenous Cohort of Monochorionic Twins
The Value of Delta Middle Cerebral Artery Peak Systolic Velocity for the Prediction of Twin Anemia-Polycythemia Sequence—Analysis of a Heterogenous Cohort of Monochorionic Twins Open
Introduction: Twin anemia-polycythemia sequence (TAPS) is a complication in monochorionic-diamniotic (MCDA) twin pregnancies. This study analyzes whether the prenatal diagnosis using delta middle cerebral artery-peak systolic velocity (MCA…
View article: Is Fetal Hydrops in Turner Syndrome a Risk Factor for the Development of Maternal Mirror Syndrome?
Is Fetal Hydrops in Turner Syndrome a Risk Factor for the Development of Maternal Mirror Syndrome? Open
Mirror syndrome is a rare and serious maternal condition associated with immune and non-immune fetal hydrops after 16 weeks of gestational age. Subjacent conditions associated with fetal hydrops may carry different risks for Mirror syndrom…
View article: Gestational diabetes mellitus and COVID-19: results from the COVID-19–Related Obstetric and Neonatal Outcome Study (CRONOS)
Gestational diabetes mellitus and COVID-19: results from the COVID-19–Related Obstetric and Neonatal Outcome Study (CRONOS) Open
View article: Antibody Response and Maternofetal Antibody Transfer in SARS-CoV-2-Positive Pregnant Women: A Multicenter Observational Study
Antibody Response and Maternofetal Antibody Transfer in SARS-CoV-2-Positive Pregnant Women: A Multicenter Observational Study Open
Introduction Awareness of SARS-CoV-2 infection in pregnant women and the potential risk for infection of their neonates is increasing. The aim of this study was to examine the immune status of affected women and evaluate the dynamics of pl…
View article: Maternal and neonatal outcomes of pregnancies with COVID-19 after medically assisted reproduction: results from the prospective COVID-19-Related Obstetrical and Neonatal Outcome Study
Maternal and neonatal outcomes of pregnancies with COVID-19 after medically assisted reproduction: results from the prospective COVID-19-Related Obstetrical and Neonatal Outcome Study Open
View article: Fallbericht: Hyperkaliämie bei systolischer Herzinsuffizienz und Niereninsuffizienz
Fallbericht: Hyperkaliämie bei systolischer Herzinsuffizienz und Niereninsuffizienz Open
View article: P170 Azathioprine metabolite (6-TGN) levels within a defined therapeutic range are associated with lower faecal calprotectin in Crohn’s disease
P170 Azathioprine metabolite (6-TGN) levels within a defined therapeutic range are associated with lower faecal calprotectin in Crohn’s disease Open
Azathioprine/6-mercaptopurine (AZA/6-MP) are first-line immunosuppressants for the treatment of Crohn’s disease. While recent studies have reported a positive association of their active metabolite 6-thioguanine (6-TGN) with clinical outco…
View article: P269 Acquisition of epidemic pseudomonas aeruginosa strains in non-cf bronchiectasis patients
P269 Acquisition of epidemic pseudomonas aeruginosa strains in non-cf bronchiectasis patients Open
Background Pseudomonas aeruginosa is an opportunistic pathogen that chronically colonises the lungs of bronchiectasis patients and is associated with a decline in lung function. Epidemic strains of P. Aeruginosa including Liv…