Corinne Cayatte
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View article: Innovative strategies for T cell engagers for cancer immunotherapy
Innovative strategies for T cell engagers for cancer immunotherapy Open
T cell engagers (TCEs) are a promising class of cancer immunotherapy that re-direct T cells to kill tumor cells. However, their clinical application is limited by several challenges, including cytokine release syndrome (CRS), on-target off…
View article: 1058 Development of AZD9793 for GPC3<sup>+</sup> solid tumor treatment: a next generation CD8-guided T cell engager with superior therapeutic index versus conventional formats
1058 Development of AZD9793 for GPC3<sup>+</sup> solid tumor treatment: a next generation CD8-guided T cell engager with superior therapeutic index versus conventional formats Open
View article: 1093 Development of TITAN: a new CD8-guided T cell engager platform for hematological and solid tumor applications
1093 Development of TITAN: a new CD8-guided T cell engager platform for hematological and solid tumor applications Open
View article: Production of native recombinant proteins using a novel split intein affinity technology
Production of native recombinant proteins using a novel split intein affinity technology Open
Affinity tags are frequently engineered into recombinant proteins to facilitate purification. Although this technique is powerful, removal of the tag is desired because the tag can interfere with biological activity and can potentially inc…
View article: Fc-mediated functions of nirsevimab complement direct respiratory syncytial virus neutralization but are not required for optimal prophylactic protection
Fc-mediated functions of nirsevimab complement direct respiratory syncytial virus neutralization but are not required for optimal prophylactic protection Open
Introduction Nirsevimab is an extended half-life (M252Y/S254T/T256E [YTE]-modified) monoclonal antibody to the pre-fusion conformation of the respiratory syncytial virus (RSV) Fusion protein, with established efficacy in preventing RSV-ass…
View article: MINERVA: Learning the Rules of HLA Class I Peptide Presentation in Tumors with Convolutional Neural Networks and Transfer Learning
MINERVA: Learning the Rules of HLA Class I Peptide Presentation in Tumors with Convolutional Neural Networks and Transfer Learning Open
View article: Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication
Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication Open
View article: CD4<sup>+</sup>T Cells Drive Lung Disease Enhancement Induced by Immunization with Suboptimal Doses of Respiratory Syncytial Virus Fusion Protein in the Mouse Model
CD4<sup>+</sup>T Cells Drive Lung Disease Enhancement Induced by Immunization with Suboptimal Doses of Respiratory Syncytial Virus Fusion Protein in the Mouse Model Open
RSV poses a significant health care burden and is the leading cause of serious lower-respiratory-tract infections in young children. A formalin-inactivated RSV vaccine developed in the 1960s not only showed a complete lack of efficacy agai…
View article: Additional file 1: of Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication
Additional file 1: of Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication Open
Flow cytometry data presented in tabular form. (XLSX 48 kb)
View article: Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice
Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice Open
Respiratory syncytial virus (RSV) is recognized as an important cause of lower and upper respiratory tract infections in older adults, and a successful vaccine would substantially lower morbidity and mortality in this age group. Recently, …
View article: Immunization with Low Doses of Recombinant Postfusion or Prefusion Respiratory Syncytial Virus F Primes for Vaccine-Enhanced Disease in the Cotton Rat Model Independently of the Presence of a Th1-Biasing (GLA-SE) or Th2-Biasing (Alum) Adjuvant
Immunization with Low Doses of Recombinant Postfusion or Prefusion Respiratory Syncytial Virus F Primes for Vaccine-Enhanced Disease in the Cotton Rat Model Independently of the Presence of a Th1-Biasing (GLA-SE) or Th2-Biasing (Alum) Adjuvant Open
Respiratory syncytial virus (RSV) infection of children previously immunized with a nonlive, formalin-inactivated (FI)-RSV vaccine has been associated with serious enhanced respiratory disease (ERD). Consequently, detailed studies of poten…
View article: Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers
Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers Open
With the goal of developing a virus-like particle-based vaccine based on dense bodies (DB) produced by human cytomegalovirus (HCMV) infections, we evaluated scalable culture, isolation, and inactivation methods and applied technically adva…
View article: Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability
Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability Open
View article: Impact of formulation and particle size on stability and immunogenicity of oil-in-water emulsion adjuvants
Impact of formulation and particle size on stability and immunogenicity of oil-in-water emulsion adjuvants Open
Oil-in-water emulsions have gained consideration as vaccine adjuvants in recent years due to their ability to elicit a differentiated immunogenic response compared to traditional aluminum salt adjuvants. Squalene, a cholesterol precursor, …