Corinne Lebreton
YOU?
Author Swipe
View article: Hepatitis B Surface Antibody Clearance After Vaccination in People With HIV
Hepatitis B Surface Antibody Clearance After Vaccination in People With HIV Open
Background People with HIV (PWH) are at higher risk of developing chronic hepatitis B, and therefore vaccination against HBV is highly recommended. Clearance of hepatitis B surface antibody (anti-HBs) over time is poorly described in PWH. …
View article: Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria
Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria Open
Host-microbiota cooperation is critical for successful intestinal homeostasis. The commensal segmented filamentous bacteria (SFB) are crucial for orchestrating the post-natal maturation of the host gut immune system and establishing a heal…
View article: DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity
DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity Open
Dedicator of cytokinesis (DOCK) proteins play a central role in actin cytoskeleton regulation. This is highlighted by the DOCK2 and DOCK8 deficiencies leading to actinopathies and immune deficiencies. DOCK8 and DOCK11 activate CDC42, a RHO…
View article: UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking
UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking Open
Variants in the UNC45A cochaperone have been recently associated with a syndrome combining diarrhea, cholestasis, deafness, and bone fragility. Yet the mechanism underlying intestinal failure in UNC45A deficiency remains unclear. Here, bia…
View article: 2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development Open
Primary cilia (PC) are non-motile dynamic microtubule-based organelles that protrude from the surface of most mammalian cells. They emerge from the older centriole during the G1/G0 phase of the cell cycle, while they disassemble as the cel…
View article: Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis
Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesis Open
Vesicle trafficking and the establishment of apico-basal polarity are essential processes in epithelium morphogenesis. Myosin-1b, an actin-motor able to bind membranes, regulates membrane shaping and vesicle trafficking. Here, we investiga…
View article: Comparison of different clearing and acquisition methods for 3D imaging of murine intestinal organoids
Comparison of different clearing and acquisition methods for 3D imaging of murine intestinal organoids Open
An organoid is a three-dimensional multicellular structure that shows realistic micro-anatomy of an organ. This in vitro model mimics the in vivo environment, architecture and multi-lineage differentiation of the origin…
View article: Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation
Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation Open
Ciliopathies are a group of genetic multi-systemic disorders related to dysfunction of the primary cilium, a sensory organelle present at the cell surface that regulates key signaling pathways during development and tissue homeostasis. In …