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View article: Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions
Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions Open
Graphical abstract Abstract Objective Colorectal cancer is a major public health issue for which dietary factors such as red and processed meat consumption seem to play a prominent role. Heme iron, which is present in important concentrati…
View article: Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats
Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats Open
View article: Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats
Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats Open
View article: Impact d'une alimentation lactée enrichie en prébiotique sur le microbiote intestinal et sur le comportement social des agneaux élevés sans leur mère
Impact d'une alimentation lactée enrichie en prébiotique sur le microbiote intestinal et sur le comportement social des agneaux élevés sans leur mère Open
Chez les mammifères, la séparation maternelle à la naissance induit un stress chronique avec pour conséquences des altérations comportementales et neurobiologiques. Ainsi, en élevage ovin, les agneaux surnuméraires sont séparés de leur mèr…
View article: Reduction, removal or replacement of sodium nitrite in a model of cured and cooked meat: a joint evaluation of consequences on microbiological issues in food safety, colon ecosystem and colorectal carcinogenesis
Reduction, removal or replacement of sodium nitrite in a model of cured and cooked meat: a joint evaluation of consequences on microbiological issues in food safety, colon ecosystem and colorectal carcinogenesis Open
Scope Epidemiological and experimental evidence reported that processed meat consumption is associated with colorectal cancer (CRC) risk. Several studies suggest the involvement of nitrite or nitrate additives via N -nitroso-compound forma…
View article: Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet‐Santé Cohort and an In Vivo Intervention Study in Rats
Urinary Metabolome Analysis Reveals Potential Microbiota Alteration and Electrophilic Burden Induced by High Red Meat Diet: Results from the French NutriNet‐Santé Cohort and an In Vivo Intervention Study in Rats Open
Scope High red and processed meat consumption is associated with several adverse outcomes such as colorectal cancer and overall global mortality. However, the underlying mechanisms remain debated and need to be elucidated. Methods and resu…
View article: Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring
Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring Open
Maternal environment, including nutrition and microbiota, plays a critical role in determining offspring's risk of chronic diseases such as diabetes later in life. Heme iron requirement is amplified during pregnancy and lactation, while ex…
View article: Su139 DIETARY HEME IRON INTAKE INDUCES GUT DYSBIOSIS AND LUMINAL REACTIVE ALDEHYDES PRODUCTION LEADING TO VISCERAL HYPERSENSITIVITY
Su139 DIETARY HEME IRON INTAKE INDUCES GUT DYSBIOSIS AND LUMINAL REACTIVE ALDEHYDES PRODUCTION LEADING TO VISCERAL HYPERSENSITIVITY Open
View article: The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Background The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial signals are not well defined. Results By comparing publicly a…
View article: Exposition nutritionnelle périnatale au fer héminique : conséquences sur l'homéostasie de l'écosystème intestinal et le métabolisme du glucose de la descendance
Exposition nutritionnelle périnatale au fer héminique : conséquences sur l'homéostasie de l'écosystème intestinal et le métabolisme du glucose de la descendance Open
National audience
View article: Le stress néonatal augmente les effets délétères d'un régime riche en fer héminique sur la muqueuse colique murine
Le stress néonatal augmente les effets délétères d'un régime riche en fer héminique sur la muqueuse colique murine Open
National audience
View article: Maternal exposure to dietary heme iron elicits sex-related gut microbiota reshape associated with gut barrier and glucose metabolism defects in mice offspring
Maternal exposure to dietary heme iron elicits sex-related gut microbiota reshape associated with gut barrier and glucose metabolism defects in mice offspring Open
View article: Additional file 4 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 4 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 3. List of all genes detected in the microarray experiment, log(fold-changes), raw p-values and corrected p-values for inter-group comparisons.
View article: Additional file 7 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 7 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 6 Gene lists for sex-biased genes. (A) List of genes significantly higher in males Pxr+/+ compared to females Pxr+/+ (male-biased genes). (B) List of genes significantly higher in males Pxr-/- compared to females Pxr-/-. (C…
View article: Additional file 6 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 6 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 5 Gene lists and GO enrichment analyses for Pxr-/- vs Pxr+/+ transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr-/- compared to males Pxr+/+. (B) GO term enrichment analysis using the list o…
View article: Additional file 9 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
Additional file 9 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice Open
Additional file 8 Gene lists and GO enrichment analyses for ATB- vs. Cont. transcriptome comparisons. (A) List of genes significantly up-regulated in males Pxr+/+ ATB compared to males Pxr+/+ Cont. (B) GO term enrichment analysis using the…
View article: Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice
Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice Open
View article: Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice
Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice Open
View article: Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice
Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice Open
Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during pe…
View article: Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model
Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model Open
Background Titanium dioxide (TiO2) is broadly used in common consumer goods, including as a food additive (E171 in Europe) for colouring and opacifying properties. The E171 additive contains TiO2 nanoparticles (NPs), part of them being abs…
View article: Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice
Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice Open
Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during pe…
View article: Impact of early-life exposure to <em>Cryptosporidium parvum</em> infection on intestinal homeostasis at adulthood
Impact of early-life exposure to <em>Cryptosporidium parvum</em> infection on intestinal homeostasis at adulthood Open
National audience
View article: Early life stress induces type 2 diabetes-like features in ageing mice
Early life stress induces type 2 diabetes-like features in ageing mice Open
View article: Additional file 1: of Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation
Additional file 1: of Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation Open
Experiment raw data and tables. (XLSX 167 kb)
View article: Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections
Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections Open
View article: Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development
Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development Open
View article: Early life stress induces glucose intolerance and insulin secretion failure in elder female mice
Early life stress induces glucose intolerance and insulin secretion failure in elder female mice Open
Early life stress induces glucose intolerance and insulin secretion failure in elder female mice. 10. International Meeting of Pediatric Endocrinology
View article: Early life stress induces type 2 diabetes at adulthood in male mice
Early life stress induces type 2 diabetes at adulthood in male mice Open
Early life stress induces type 2 diabetes at adulthood in male mice. 10. International Meeting of Pediatric Endocrinology
View article: Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity
Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity Open
View article: Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice
Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice Open
Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice. Digestive Disease Week (DDW)