Corinne Liesnard
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View article: Functional Exhaustion Limits CD4<sup>+</sup>and CD8<sup>+</sup>T-Cell Responses to Congenital Cytomegalovirus Infection
Functional Exhaustion Limits CD4<sup>+</sup>and CD8<sup>+</sup>T-Cell Responses to Congenital Cytomegalovirus Infection Open
Functional exhaustion limits effector CD4(+) and CD8(+) T-lymphocyte responses to CMV during fetal life.
View article: Human cytomegalovirus elicits fetal γδ T cell responses in utero
Human cytomegalovirus elicits fetal γδ T cell responses in utero Open
The fetus and infant are highly susceptible to viral infections. Several viruses, including human cytomegalovirus (CMV), cause more severe disease in early life compared with later life. It is generally accepted that this is a result of th…
View article: Correction of Underquantification of Human Immunodeficiency Virus Type 1 Load with the Second Version of the Roche Cobas AmpliPrep/Cobas TaqMan Assay
Correction of Underquantification of Human Immunodeficiency Virus Type 1 Load with the Second Version of the Roche Cobas AmpliPrep/Cobas TaqMan Assay Open
Initial evaluations of the Cobas AmpliPrep/Cobas TaqMan human immunodeficiency virus type 1 (HIV-1) test (CAP/CTM) demonstrated good performance but, afterwards, reports about underquantification were published. We investigated whether the…
View article: CD4+ T lymphocyte response to primary CMV infection
CD4+ T lymphocyte response to primary CMV infection Open
Primary cytomegalovirus (CMV) infection induces rapid expansion of CMV-specific cytokine-producing CD4+ T cells but slow acquisition of proliferative responses. In utero transmission of CMV following maternal infection is associated with l…
View article: Lower‐Limb Hypoplasia Due to Intrauterine Infection with Herpes Simplex Virus Type 2: Possible Confusion with Intrauterine Varicella‐Zoster Syndrome
Lower‐Limb Hypoplasia Due to Intrauterine Infection with Herpes Simplex Virus Type 2: Possible Confusion with Intrauterine Varicella‐Zoster Syndrome Open
A neonate with lower-limb hypoplasia, cutaneous scars, bilateral chorioretinitis, and multiple brain abnormalities is presented. Intrauterine herpes simplex virus type 2 (HSV-2) infection was established on the basis of serological testing…
View article: Mature CD8+ T lymphocyte response to viral infection during fetal life
Mature CD8+ T lymphocyte response to viral infection during fetal life Open
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with congenital human cytomegalovirus (HCMV) infe…
View article: Screening standards in assisted reproductive technologies
Screening standards in assisted reproductive technologies Open
The British Andrology Society recently recommended the exclusion of all cytomegalovirus (CMV) seropositive semen donors to prevent the risk of congenital CMV infection. The recommendation is based on the results of recent studies that iden…
View article: A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line
A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line Open
Human immunodeficiency virus type 1 (HIV-1) growth in lymphocyte cultures was increased when the virus inoculum was incubated in breast milk. The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cath…
View article: Iron as a potential co‐factor in the pathogenesis of Kaposi's sarcoma?
Iron as a potential co‐factor in the pathogenesis of Kaposi's sarcoma? Open
The role of iron in the pathogenesis of several tumours is being increasingly investigated. In particular, its involvement in the pathogenesis of Kaposi's sarcoma (KS) is suggested by the distribution of the endemic form of KS correspondin…
View article: Screening of semen donors for infectious diseases
Screening of semen donors for infectious diseases Open
The aim of this work was to prepare European guidelines concerning the screening for infectious diseases in the setting of gamete donation. Existing guidelines have been reviewed and commented. In particular, the problem of cytomegalovirus…
View article: Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation
Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation Open
The alpha-chemokine receptor fusin (CXCR-4) and beta-chemokine receptor CCR5 serve as entry cofactors for T-cell (T)-tropic and macrophage (M)-tropic human immunodeficiency virus type 1 (HIV-1) strains, respectively, when expressed with CD…
View article: Markers of HTLV-III in patients with end stage renal failure treated by haemodialysis.
Markers of HTLV-III in patients with end stage renal failure treated by haemodialysis. Open
Patients and members of staff from a haemodialysis unit were tested for markers of infection with human T cell lymphotropic virus type III (HTLV-III), the virus associated with the acquired immune deficiency syndrome (AIDS). An enzyme link…