Cornel Chiriţă
YOU?
Author Swipe
View article: Identification, analysis and prediction of valid and false information related to vaccines from Romanian tweets
Identification, analysis and prediction of valid and false information related to vaccines from Romanian tweets Open
Introduction The online misinformation might undermine the vaccination efforts. Therefore, given the fact that no study specifically analyzed online vaccine related content written in Romanian, the main objective of the study was to detect…
View article: Oral antithrombotics’ perioperative use
Oral antithrombotics’ perioperative use Open
Antithrombotics use is especially challenging in contexts with a high risk of bleeding, such as surgery or some diagnostic procedures. Depending on the patient's thromboembolic risk and bleeding risk, antithrombotic therapy is often, but n…
View article: Practical issues about hormonal contraception
Practical issues about hormonal contraception Open
View article: Rheumatoid arthritis pharmacotherapeutic management
Rheumatoid arthritis pharmacotherapeutic management Open
Rheumatoid arthritis is a disabling chronic autoimmune condition. Early initiation of pharmacological therapy, as close as possible to the time of diagnosis, is essential for a quality care of patients with rheumatoid arthritis. The primar…
View article: Identification, analysis and prediction of valid and false information related to vaccines from Romanian tweets
Identification, analysis and prediction of valid and false information related to vaccines from Romanian tweets Open
The online misinformation might undermine the vaccination efforts. Therefore, given the fact that no study specifically analyzed online vaccine related content written in Romanian, the main objective of the study was to detect and evaluate…
View article: N-Substituted (Hexahydro)-1H-isoindole-1,3(2H)-dione Derivatives: New Insights into Synthesis and Characterization
N-Substituted (Hexahydro)-1H-isoindole-1,3(2H)-dione Derivatives: New Insights into Synthesis and Characterization Open
Novel phthalimide derivatives, namely N-(1,3-dioxoisoindolin-2-yl)-2-(2-methyl-4-oxoquinazolin-3(4H)-yl)acetamide (1a) and N-(1,3-dioxoisoindolin-2-yl)thiophene-2-carboxamide (1b), and hexahydrophthalimide derivative N-(1,3-dioxohexahydro-…
View article: New N-acyl Thiourea Derivatives: Synthesis, Standardized Quantification Method and In Vitro Evaluation of Potential Biological Activities
New N-acyl Thiourea Derivatives: Synthesis, Standardized Quantification Method and In Vitro Evaluation of Potential Biological Activities Open
New N-acyl thiourea derivatives with heterocyclic rings have been synthesized by first obtaining isothiocyanate, which further reacted with a heterocyclic amine, characterized by (FT-IR, NMR spectroscopy and FT-ICR) and tested for their in…
View article: Trends in type 2 diabetes treatment
Trends in type 2 diabetes treatment Open
The current guidelines for the management of type 2 diabetes mellitus (T2DM) recommend the use from the early stages of therapy of drugs that, in addition to the antihyperglycemic effect, also have cardio-renal protective effects, in those…
View article: Antimicrobial stewardship (I)
Antimicrobial stewardship (I) Open
Antimicrobial stewardship is one of the current challenges in pharmacotherapy, mainly due to the development of antimicrobial resistance. The paper discusses the current principles of antibiotic therapy, starting from the classification of…
View article: What’s new in heart failure treatment?
What’s new in heart failure treatment? Open
Heart failure is one of the leading causes of morbidity globally, with an increasing incidence. Heart failure is a progressive, multi-causal syndrome with three phenotypic manifestations: heart failure with reduced ejection fraction, heart…
View article: Chronic kidney disease and the use of drugs
Chronic kidney disease and the use of drugs Open
Chronic kidney disease occurs insidiously and is usually diagnosed in advanced stages when its evolution is more difficult to control. Frequently, it is favored by inadequately controlled hypertension and/or insufficiently controlled diabe…
View article: Antipsychotics
Antipsychotics Open
Schizophrenia is a psychiatric condition characterized by positive and negative symptoms, affecting cognition, social behavior and mood. There are several hypotheses regarding the pathophysiology of schizophrenia. Abnormalities in dopamine…
View article: Drug-induced nephrotoxicity
Drug-induced nephrotoxicity Open
Many drugs are nephrotoxic, affecting the kidneys by different mechanisms. Renal iatrogenicity mainly affects patients with risk factors. Measures to prevent drugs nephrotoxicity include using of non-nephrotoxic drugs whenever possible, do…
View article: Novel Structures of Functionalized Graphene Oxide with Hydrazide: Characterization and Bioevaluation of Antimicrobial and Cytocompatibility Features
Novel Structures of Functionalized Graphene Oxide with Hydrazide: Characterization and Bioevaluation of Antimicrobial and Cytocompatibility Features Open
Graphite was oxidized to graphene oxide and activated by thionyl chloride, for further covalently linking three hydrazides with potential biological activity. The obtained materials were characterized by scanning electron microscopy with e…
View article: Managementul comprehensiv al medicaţiei – partea I
Managementul comprehensiv al medicaţiei – partea I Open
Comprehensive medication management (CMM) is a standard of patient-centered pharmaceutical care, through which the clinical pharmacist simultaneously achieves several goals (ensures better clinical outcomes and improves the patient experie…
View article: Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress
Effects of Venlafaxine, Risperidone and Febuxostat on Cuprizone-Induced Demyelination, Behavioral Deficits and Oxidative Stress Open
Multiple sclerosis (MS) is a demyelinating, autoimmune disease that affects a large number of young adults. Novel therapies for MS are needed considering the efficiency and safety limitations of current treatments. In our study, we investi…
View article: Contribution of Essential Oils to the Fight against Microbial Biofilms—A Review
Contribution of Essential Oils to the Fight against Microbial Biofilms—A Review Open
The increasing clinical use of artificial medical devices raises the issue of microbial contamination, which is a risk factor for the occurrence of biofilm-associated infections. A huge amount of scientific data highlights the promising po…
View article: Vaccinarea anti-COVID-19
Vaccinarea anti-COVID-19 Open
The COVID-19 pandemic is the most important public health challenge facing humankind in the 3rd millennium to date. It also has myriad of economic, political and social implications. In addition to behavioral measures, vaccines are the sol…
View article: Comprehensive medication management – part I
Comprehensive medication management – part I Open
Comprehensive medication management (CMM) is a standard of patient-centered pharmaceutical care, through which the clinical pharmacist simultaneously achieves several goals (ensures better clinical outcomes and improves the patient experie…
View article: Immunotherapeutics
Immunotherapeutics Open
Lately, one of the most developed therapeutic areas has been that of drugs that display their therapeutic effects by involving the immune system. Monoclonal antibodies are the most well-known such drugs. Immunotherapeutic agents are drugs …
View article: COVID-19 vaccines
COVID-19 vaccines Open
The COVID-19 pandemic is the most important public health challenge facing humankind in the 3rd millennium to date. It also has myriad of economic, political and social implications. In addition to behavioral measures, vaccines are the sol…
View article: Immunotherapeutics (II)
Immunotherapeutics (II) Open
Immunotherapeutics have revolutionized the treatment of many severe conditions. Monoclonal antibodies and other biologics that act on the immune system or by similarity with components of the immune system are targeted drugs, which address…
View article: Migrena, adesea mai mult decât o durere de cap
Migrena, adesea mai mult decât o durere de cap Open
Migraine is a type of headache that profoundly decreases the quality of life. Migraine manifests with attacks, with or without aura. It differs from other headaches by symptoms, prevalence and physiopathogenic mechanism. Antimigraine drugs…
View article: Utilizarea medicamentelor în perioada perioperatorie
Utilizarea medicamentelor în perioada perioperatorie Open
The paper addresses the use of general anesthetics, local anesthetics and other drugs used in preanesthesia for the proper conduct of surgical interventions. Antibioprophylaxis of postsurgical infections and postoperative analgesia are oth…
View article: Medicamente antivirale (III). Tratamentul infecţiilor provocate de herpesvirusuri umane
Medicamente antivirale (III). Tratamentul infecţiilor provocate de herpesvirusuri umane Open
Human herpesviruses are DNA viruses that can cause acute or chronic infections, some asymptomatic and others very severe, such as herpes encephalopathy. Some of these viruses, such as Epstein-Barr virus, are associated with malignant proce…
View article: Medicamente antivirale (II) Virusuri hepatice şi tratamentul hepatitelor virale
Medicamente antivirale (II) Virusuri hepatice şi tratamentul hepatitelor virale Open
Viral hepatitis are acute or chronic infections caused by viruses with liver tropism.
Viral hepatitis’ profilaxy and treatment can prevent cirrhosis, end‑stage liver disease or hepatocellular carcinoma. Hepatitis A and hepatitis B vaccine…
View article: Medicamente antivirale (I) Generalităţi. Antiretrovirale. Medicamente folosite în infecţii produse de virusurile respiratorii
Medicamente antivirale (I) Generalităţi. Antiretrovirale. Medicamente folosite în infecţii produse de virusurile respiratorii Open
Viruses are the smallest and simplest pathogens, necessarily intracellular, that use the metabolic apparatus of the host cell to multiply. To enter into invaded cells, they use pre-existing host structures, so viruses have tropism for thos…
View article: In Silico and In Vitro Experimental Studies of New Dibenz[b,e]oxepin-11(6H)one O-(arylcarbamoyl)-oximes Designed as Potential Antimicrobial Agents
In Silico and In Vitro Experimental Studies of New Dibenz[b,e]oxepin-11(6H)one O-(arylcarbamoyl)-oximes Designed as Potential Antimicrobial Agents Open
In a drug-repurposing-driven approach for speeding up the development of novel antimicrobial agents, this paper presents for the first time in the scientific literature the synthesis, physico-chemical characterization, in silico analysis, …
View article: Perioperative use of drugs
Perioperative use of drugs Open
The paper addresses the use of general anesthetics, local anesthetics and other drugs used in preanesthesia for the proper conduct of surgical interventions. Antibioprophylaxis of postsurgical infections and postoperative analgesia are oth…
View article: The migraine, most of the time more than a headache
The migraine, most of the time more than a headache Open
Migraine is a type of headache that profoundly decreases the quality of life. Migraine manifests with attacks, with or without aura. It differs from other headaches by symptoms, prevalence and physiopathogenic mechanism. Antimigraine drugs…