Cornelia A. Karg
YOU?
Author Swipe
View article: Photoprotective mycosporine-like amino acids in different organs of Baltic flatfish species revealed by targeted and untargeted metabolomics analyses
Photoprotective mycosporine-like amino acids in different organs of Baltic flatfish species revealed by targeted and untargeted metabolomics analyses Open
Coastal marine organisms are often exposed to high levels of biologically harmful ultraviolet radiation (UVR), the most photochemically reactive waveband of sunlight. It is well known that marine organisms at higher trophic levels, such as…
View article: Phyllobilins derived from chlorophyll degradation are overlooked, bioactive phytochemicals in plant-based food
Phyllobilins derived from chlorophyll degradation are overlooked, bioactive phytochemicals in plant-based food Open
View article: Characterization of Phyllobilins in Hops: Antioxidant and Potentially Bitter Senescence-Related Metabolites
Characterization of Phyllobilins in Hops: Antioxidant and Potentially Bitter Senescence-Related Metabolites Open
Hops is of high relevance to the food sector, and increasingly valued as medicinal plant. Its complex phytochemistry includes phenolic compounds and bitter prenylated polyketides, but phyllobilins─bioactive linear tetrapyrroles from chloro…
View article: Key determinants of the chemo-sensitizing activity of novel Telmisartan derivatives
Key determinants of the chemo-sensitizing activity of novel Telmisartan derivatives Open
Despite the success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML), resistance remains a major challenge due to target mutations and drug efflux. To counter this, chemo-sensitizers - non-cytotoxic agents th…
View article: Extracellular spermidine attenuates tryptophan breakdown in mitogen-stimulated peripheral human mononuclear blood cells
Extracellular spermidine attenuates tryptophan breakdown in mitogen-stimulated peripheral human mononuclear blood cells Open
Polyamines, particularly spermidine, play a vital role in regulating cellular functions and influencing processes such as proliferation, ageing, and immune modulation. This study explores the effects of spermidine on the immunoregulatory p…
View article: ExonSurfer: a web-tool to design primers at exon–exon junctions
ExonSurfer: a web-tool to design primers at exon–exon junctions Open
Background Reverse transcription quantitative PCR (RT-qPCR) with intercalating dyes is one of the main techniques to assess gene expression levels used in basic and applied research as well as in diagnostics. However, primer design for RT-…
View article: A Chlorophyll-Derived Phylloxanthobilin Is a Potent Antioxidant That Modulates Immunometabolism in Human PBMC
A Chlorophyll-Derived Phylloxanthobilin Is a Potent Antioxidant That Modulates Immunometabolism in Human PBMC Open
Phyllobilins are natural products derived from the degradation of chlorophyll, which proceeds via a common and strictly controlled pathway in higher plants. The resulting tetrapyrrolic catabolites—the phyllobilins—are ubiquitous in nature;…
View article: Using the yeast three-hybrid system for the identification of small molecule-protein interactions with the example of ethinylestradiol
Using the yeast three-hybrid system for the identification of small molecule-protein interactions with the example of ethinylestradiol Open
Since the first report on a yeast three-hybrid system, several approaches have successfully utilized different setups for discovering targets of small molecule drugs. Compared to broadly applied MS based target identification approaches, t…
View article: Rising levels of antioxidative phyllobilins in stored agricultural produce and their impact on consumer acceptance
Rising levels of antioxidative phyllobilins in stored agricultural produce and their impact on consumer acceptance Open
View article: Tetrapyrrolic Pigments from Heme‐ and Chlorophyll Breakdown are Actin‐Targeting Compounds
Tetrapyrrolic Pigments from Heme‐ and Chlorophyll Breakdown are Actin‐Targeting Compounds Open
Chlorophyll and heme are among the “pigments of life”, tetrapyrrolic structures, without which life on Earth would not be possible. Their catabolites, the phyllobilins and the bilins, respectively, share not only structural features, but a…
View article: Tetrapyrrolische Pigmente aus dem Häm‐ und Chlorophyllabbau interagieren mit Aktin
Tetrapyrrolische Pigmente aus dem Häm‐ und Chlorophyllabbau interagieren mit Aktin Open
Chlorophyll und Häm sind sogenannte “Pigmente des Lebens”, tetrapyrrolische Strukturen, ohne die das Leben auf der Erde nicht möglich wäre. Ihre Abbauprodukte, die Phyllobiline bzw. die Biline, teilen nicht nur strukturelle Merkmale, sonde…
View article: Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities
Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities Open
Phyllobilins are a group of chlorophyll‐derived bilin‐type linear tetrapyrroles, generated in the process of chlorophyll breakdown. Since the first phyllobilin was isolated and characterized in 1991, more and more structures of these chlor…
View article: Phylloxanthobilins are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities Against Cancer Cells
Phylloxanthobilins are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities Against Cancer Cells Open
Linear tetrapyrroles, called phyllobilins, are obtained as major catabolites upon chlorophyll degradation. Primarily, colorless phylloleucobilins featuring four deconjugated pyrrole units were identified. Their yellow counterparts, phyllox…