Cornelia Betschart
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View article: Robotic-assisted laparoscopic niche repair (RALNR): technique development and pregnancy-associated outcomes
Robotic-assisted laparoscopic niche repair (RALNR): technique development and pregnancy-associated outcomes Open
Uterine scar defects after cesarean sections are increasingly common and elevate the risk of life-threatening complications in subsequent pregnancies. From various sonomorphological measurement parameters, the residual myometrial thickness…
View article: Monitoring sexual hormones in women going to high altitude—a pilot study
Monitoring sexual hormones in women going to high altitude—a pilot study Open
Background The susceptibility to acute mountain sickness (AMS) in relation to sexual hormones in women remains elusive, partly because hormones could not be conveniently measured. We evaluated a novel kit for self-monitoring sexual hormone…
View article: Morphometric Characterization of Levator Ani Subdivisions in Healthy Controls and Patients: An MRI Study Using 3D PICS
Morphometric Characterization of Levator Ani Subdivisions in Healthy Controls and Patients: An MRI Study Using 3D PICS Open
Introduction and Hypothesis To date, levator ani muscle (LAM) morphometry has been classified descriptively and semi-quantitatively. New MRI techniques enabling detailed visualization with the 3D pelvic inclination correction system (3D PI…
View article: Monitoring sexual hormones in women going to high altitude – a pilot study
Monitoring sexual hormones in women going to high altitude – a pilot study Open
Background The susceptibility to acute mountain sickness (AMS) in relation to sexual hormones in women remains elusive, partly because hormones could not be conveniently measured. We evaluated a novel kit for self-monitoring sexual hormone…
View article: Vulvodynia, Genital Eczema and Lichen Sclerosus: What are the Successful Treatments from a Patient’s Perspective?
Vulvodynia, Genital Eczema and Lichen Sclerosus: What are the Successful Treatments from a Patient’s Perspective? Open
In conclusion, we found that in the patients' perception, topical, invasive and non-pharmacological treatments, but not oral medications, are helpful for genital pain relief in women with vulvodynia, vulvar eczema, and lichen sclerosus. Th…
View article: Quantitative 3D Analysis of Levator Ani Muscle Subdivisions in Nulliparous Women: MRI Feasibility Study
Quantitative 3D Analysis of Levator Ani Muscle Subdivisions in Nulliparous Women: MRI Feasibility Study Open
Background: The levator ani muscle (LAM) is crucial for pelvic floor stability, yet its quantitative MRI assessment is only a recent focus. Our study aims to standardize the quantitative analysis of the LAM morphology within the 3D Pelvic …
View article: Assessment of pelvic organ prolapse with the Pelvic Inclination Correction System: defining the normal range and threshold to pathology
Assessment of pelvic organ prolapse with the Pelvic Inclination Correction System: defining the normal range and threshold to pathology Open
Purpose To define the normal range and threshold values for pathologic prolapse on MRI using the PICS line and assess its correlation with the pubococcygeal line (PCL). Methods This prospective, IRB-approved study included 20 nulliparous v…
View article: Impact of vaginal estriol on endometrial tissue - a systematic review
Impact of vaginal estriol on endometrial tissue - a systematic review Open
Main outcome(s) sonographically thickened endometrium, need for biopsy, postmenopausal bleeding, endometrial hyperplasia, endometrial cancerQuality assessment / Risk of bias analysis Randomization, blinding, inclusion and exclusion criteri…
View article: Impact of vaginal estriol on breast cancer outcomes - a systematic review
Impact of vaginal estriol on breast cancer outcomes - a systematic review Open
Main outcome(s) breast cancer recurrence, death, mammographic features, endometrial changes, medication side effects, serum level of estrogens and gonadotropins. Quality assessment / Risk of bias analysisRandomization, blinding, inclusion …
View article: Effects of vaginal estriol on genitourinary syndrome of menopause (GSM) - a systematic review
Effects of vaginal estriol on genitourinary syndrome of menopause (GSM) - a systematic review Open
Intervention Inclusion: intravaginal administration of estriol.Exclusion: other routes of estriol administration.Comparator Inclusion: intravaginal administration of estriol of different dosage, intravaginal a d m i n i s t r a t i o n o f…
View article: Impact of vaginal estriol on healthy breast tissue - a systematic review
Impact of vaginal estriol on healthy breast tissue - a systematic review Open
Main outcome(s) breast cancer incidence, mammographic or sonographic features, need for breast biopsies, findings on palpation, serum level of estrogens and gonadotropins. Quality assessment / Risk of bias analysisRandomization, blinding, …
View article: MRI characterization of pelvic floor ligaments in nulliparous women: Technique development and morphometry within the 3D pelvic inclination correction system (3D-PICS)
MRI characterization of pelvic floor ligaments in nulliparous women: Technique development and morphometry within the 3D pelvic inclination correction system (3D-PICS) Open
This in-vivo MRI technique development study offers first exact data describing the pelvic floor ligaments in nulliparous women in 3D-PICS. Visibility, exact 3D coordinates of the origin and insertion points, lengths, angles and interrater…
View article: Impact of vaginal estriol on serum hormone levels: a systematic review
Impact of vaginal estriol on serum hormone levels: a systematic review Open
The genitourinary syndrome of menopause (GSM) affects up to 84% of postmenopausal women and may significantly reduce the quality of life in some. For symptom relief, there are several non-hormonal and hormonal vaginal products available. I…
View article: Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series
Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series Open
Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the m…
View article: Transurethral injection of autologous muscle precursor cells for treatment of female stress urinary incontinence: a prospective phase I clinical trial
Transurethral injection of autologous muscle precursor cells for treatment of female stress urinary incontinence: a prospective phase I clinical trial Open
Introduction and hypothesis The purpose was to investigate the safety and feasibility of transurethral injections of autologous muscle precursor cells (MPCs) into the external urinary sphincter (EUS) to treat stress urinary incontinence (S…
View article: <i>Bryophyllum pinnatum</i> and Improvement of Nocturia and Sleep Quality in Women: A Multicentre, Nonrandomised Prospective Trial
<i>Bryophyllum pinnatum</i> and Improvement of Nocturia and Sleep Quality in Women: A Multicentre, Nonrandomised Prospective Trial Open
Nocturia is a pathologic condition that significantly affects the quality of sleep. The aetiology of nocturia is multifactorial, and the evidence available on its management remains limited. Besides behavioural measures, validated pharmace…
View article: Outcome reporting in randomized controlled trials (RCTs) on the pharmacological management of idiopathic overactive bladder (OAB) in women; a systematic review for the development of core outcome sets (COS)
Outcome reporting in randomized controlled trials (RCTs) on the pharmacological management of idiopathic overactive bladder (OAB) in women; a systematic review for the development of core outcome sets (COS) Open
Introduction and hypothesis Evidence on OAB management remains suboptimal and methodological limitations in randomized control trials (RCTs) affect their comparability. High quality meta-analyses are lacking. This study aimed to compare se…
View article: Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study
Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study Open
Background Studies evaluating cosmetic gynecological interventions have followed variable methodology and reported a diversity of outcomes. Such variations limit the comparability of studies and the value of research-based evidence. The de…
View article: Quality assessment of outcome reporting, publication characteristics and overall methodological quality in trials on synthetic mesh procedures for the treatment of pelvic organ prolapse for development of core outcome sets
Quality assessment of outcome reporting, publication characteristics and overall methodological quality in trials on synthetic mesh procedures for the treatment of pelvic organ prolapse for development of core outcome sets Open
Introduction and hypothesis Variations in outcome measures and reporting of outcomes in trials on surgery for pelvic organ prolapse (POP) using synthetic mesh have been evaluated and reported. However, the quality of outcome reporting, met…
View article: Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study (Preprint)
Developing Core Outcome Sets (COS) and Core Outcome Measures Sets (COMS) in Cosmetic Gynecological Interventions: Protocol for a Development and Usability Study (Preprint) Open
BACKGROUND Studies evaluating cosmetic gynecological interventions have followed variable methodology and reported a diversity of outcomes. Such variations limit the comparability of studies and the value of research-based evidence. The d…
View article: Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis
Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis Open
Background: Chronic vulvar dermatitis (CVD) is the most prevalent disease in gynecologic dermatology. The treatment mainly depends on topical glucocorticoids (TGC) but is challenged by insufficient treatment response. On a histological lev…