Cornelia G. Palivan
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View article: Diphtheria toxin T-domain as a tool for inducing lipid vesicle fusion
Diphtheria toxin T-domain as a tool for inducing lipid vesicle fusion Open
Membrane fusion is fundamental for many biological processes, including subcellular compartmentalization, cell growth, and exo- and endocytosis. It also plays a key role in the fabrication of artificial membrane structures, particularly ve…
View article: Engineering pH‐Responsive Nanocarriers via an Optimized Synthesis of PMOXA‐<i>b</i>‐PDPA Amphiphilic Diblock Copolymers
Engineering pH‐Responsive Nanocarriers via an Optimized Synthesis of PMOXA‐<i>b</i>‐PDPA Amphiphilic Diblock Copolymers Open
pH‐responsive nanocarriers have gain significant attention due to their ability to provide controlled cargo delivery with high precision in response to specific stimuli. However, the polymers used in the self‐assembly of these nanocarriers…
View article: Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells
Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells Open
Protocells, by breaking down the intricate complexity of eukaryotic cells, are innovative tools for mimicking and understanding cellular phenomena. Protocells based on giant unilamellar vesicles (GUVs) supplemented with active species faci…
View article: Targeted apoptotic immune modulator for the treatment of metastatic EGFR-positive solid tumors
Targeted apoptotic immune modulator for the treatment of metastatic EGFR-positive solid tumors Open
Aberrant activation and overexpression of the epidermal growth factor receptor (EGFR) occurs in various solid cancers and often correlates with poor outcome. The clinical benefit from EGFR-targeted therapies is usually short-lived, with re…
View article: Solid-Supported Polymer Membranes: How Different Deposition Methods Influence Their Inner Morphology and Properties
Solid-Supported Polymer Membranes: How Different Deposition Methods Influence Their Inner Morphology and Properties Open
Solid-supported polymer membranes (SSPMs) resulting from the self-assembly of amphiphilic block copolymers are in focus for the development of functional surfaces with enhanced stability and more chemical versatility compared to lipid-base…
View article: Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells
Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells Open
Protocells offer a versatile material for dissecting cellular processes and developing simplified biomimetic systems by combining biological components with synthetic ones. However, a gap exists between the integrity and complex functional…
View article: Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery
Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery Open
Thermoresponsive polymers, which undergo phase transitions within physiologically tolerated temperatures, are key to developing drug delivery systems (DDS) with precise spatial and temporal control, potentially addressing challenges associ…
View article: Hydrogel–polymersome composites as a sensing platform for monitoring food spoilage
Hydrogel–polymersome composites as a sensing platform for monitoring food spoilage Open
Hydrogel–polymersome composites acting as sensors for food spoilage detection and as ‘sense-and-release’ devices. The graphical abstract was created in BioRender. Kraus, M. (2025) https://BioRender.com/n22p907.
View article: Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles
Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles Open
Dual-functional antibacterial surfaces combining sustained antibiotic release and contact-based bactericidal activity reduce bacterial adhesion and biofilm formation.
View article: Nano Plasma Membrane Vesicle‐Lipid Nanoparticle Hybrids for Enhanced Gene Delivery and Expression
Nano Plasma Membrane Vesicle‐Lipid Nanoparticle Hybrids for Enhanced Gene Delivery and Expression Open
Lipid nanoparticles (LNPs) have emerged as the leading nonviral nucleic acid (NA) delivery system, gaining widespread attention for their use in COVID‐19 vaccines. They are recognized for their efficient NA encapsulation, modifiability, an…
View article: Photoreceptor‐Like Signal Transduction Between Polymer‐Based Protocells
Photoreceptor‐Like Signal Transduction Between Polymer‐Based Protocells Open
Deciphering inter‐ and intracellular signaling pathways is pivotal for understanding the intricate communication networks that orchestrate life's dynamics. Communication models involving bottom‐up construction of protocells are emerging bu…
View article: Redefining drug therapy: innovative approaches using catalytic compartments
Redefining drug therapy: innovative approaches using catalytic compartments Open
Catalytic compartments hold transformative potential in precision medicine by improving therapeutic outcomes through precise, on-site production of therapeutic agents. While promising, challenges like scalable manufacturing, biodegradabili…
View article: Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier
Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier Open
The fundamental building block of living organisms is the cell, which is the universal biological base of all living entities. This micrometric mass of cytoplasm and the membrane border have fascinated scientists due to the highly complex …
View article: Stimuli‐Responsive Prototissues via DNA‐Mediated Self‐Assembly of Polymer Giant Unilamellar Vesicles
Stimuli‐Responsive Prototissues via DNA‐Mediated Self‐Assembly of Polymer Giant Unilamellar Vesicles Open
Gaining insight into the complex functions of tissues, which involve communicating cell types, by utilizing materials that mimic the properties of real tissue, is an important step in developing advanced biomedical applications. However, b…
View article: Glycooligomer-Functionalized Catalytic Nanocompartments Co-Loaded with Enzymes Support Parallel Reactions and Promote Cell Internalization
Glycooligomer-Functionalized Catalytic Nanocompartments Co-Loaded with Enzymes Support Parallel Reactions and Promote Cell Internalization Open
A major shortcoming associated with the application of enzymes in drug synergism originates from the lack of site-specific, multifunctional nanomedicine. This study introduces catalytic nanocompartments (CNCs) made of a mixture of PDMS-b-P…
View article: Nanoassemblies designed for efficient nuclear targeting
Nanoassemblies designed for efficient nuclear targeting Open
One of the key aspects of coping efficiently with complex pathological conditions is delivering the desired therapeutic compounds with precision in both space and time. Therefore, the focus on nuclear-targeted delivery systems has emerged …
View article: Tweaking the NRF2 signaling cascade in human myelogenous leukemia cells by artificial nano-organelles
Tweaking the NRF2 signaling cascade in human myelogenous leukemia cells by artificial nano-organelles Open
NRF2 (nuclear factor erythroid-2-related factor 2) is a key regulator of genes involved in the cell’s protective response to oxidative stress. Upon activation by disturbed redox homeostasis, NRF2 promotes the expression of metabolic enzyme…
View article: High-Throughput Silica Nanoparticle Detection for Quality Control of Complex Early Life Nutrition Food Matrices
High-Throughput Silica Nanoparticle Detection for Quality Control of Complex Early Life Nutrition Food Matrices Open
The addition of nanomaterials to improve product properties has become a matter of course for many commodities: e.g., detergents, cosmetics, and food products. While this practice improves product characteristics, the increasing exposure a…
View article: Advancing the Design of Artificial Nano-organelles for Targeted Cellular Detoxification of Reactive Oxygen Species
Advancing the Design of Artificial Nano-organelles for Targeted Cellular Detoxification of Reactive Oxygen Species Open
Artificial organelles (AnOs) are in the spotlight as systems to supplement biochemical pathways in cells. While polymersome-based artificial organelles containing enzymes to reduce reactive oxygen species (ROS) are known, applications requ…
View article: FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing
FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing Open
As current chemo- and photodynamic cancer therapies are associated with severe side effects due to a lack of specificity and to systemic toxicity, innovative solutions in terms of targeting and controlled functionality are in high demand. …
View article: Thermocatalytic epoxidation by cobalt sulfide inspired by the material's electrocatalytic activity for oxygen evolution reaction
Thermocatalytic epoxidation by cobalt sulfide inspired by the material's electrocatalytic activity for oxygen evolution reaction Open
Cobalt sulfide catalyzes epoxidation reactions with parallels in the surface chemistry to electrocatalytic oxygen evolution reaction by the same material.
View article: Microfluidic Giant Polymer Vesicles Equipped with Biopores for High‐Throughput Screening of Bacteria
Microfluidic Giant Polymer Vesicles Equipped with Biopores for High‐Throughput Screening of Bacteria Open
Understanding the mechanisms of antibiotic resistance is critical for the development of new therapeutics. Traditional methods for testing bacteria are often limited in their efficiency and reusability. Single bacterial cells can be studie…
View article: Synthetic Cells Revisited: Artificial Cell Construction Using Polymeric Building Blocks
Synthetic Cells Revisited: Artificial Cell Construction Using Polymeric Building Blocks Open
The exponential growth of research on artificial cells and organelles underscores their potential as tools to advance the understanding of fundamental biological processes. The bottom–up construction from a variety of building blocks at th…
View article: Microfluidic Giant Polymer Vesicles Equipped with Biopores for High-Throughput Screening of Bacteria
Microfluidic Giant Polymer Vesicles Equipped with Biopores for High-Throughput Screening of Bacteria Open
Understanding the mechanisms of antibiotic resistance is critical for the development of new therapeutics. Traditional methods for testing bacteria are often limited in their efficiency and reusability. Single bacterial cells can be studie…
View article: Microfluidic Giant Polymer Vesicles Equipped with Biopores for High-Throughput Screening of Bacteria
Microfluidic Giant Polymer Vesicles Equipped with Biopores for High-Throughput Screening of Bacteria Open
Understanding the mechanisms of antibiotic resistance is critical for the development of new therapeutics. Traditional methods for testing bacteria are often limited in their efficiency and reusability. Single bacterial cells can be studie…
View article: Obituary – Prof. Dr. Wolfgang Peter Meier (1964–2022)
Obituary – Prof. Dr. Wolfgang Peter Meier (1964–2022) Open
Front Cover: This special issue is dedicated to commemorate Wolfgang P. Meier, who had significant contributions in the fields of amphiphilic copolymer syntheses and their hierarchical self-assembly, block copolymer vesicles (so-called pol…
View article: Obituary – Prof. Dr. Wolfgang Peter Meier (1964–2022)
Obituary – Prof. Dr. Wolfgang Peter Meier (1964–2022) Open
The colloid and polymer science, as well as the physical chemistry communities were deeply saddened to learn about the premature death of Professor Dr. Wolfgang Peter Meier. He passed away on the 25th January 2022, after fighting relentles…
View article: Obituary – Prof. Dr. Wolfgang Peter Meier (1964–2022)
Obituary – Prof. Dr. Wolfgang Peter Meier (1964–2022) Open
Front Cover: This special issue is dedicated to commemorate Wolfgang P. Meier, who had significant contributions in the fields of amphiphilic copolymer syntheses and their hierarchical self-assembly, block copolymer vesicles (so-called pol…