Cornelia Hagmann
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View article: Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns
Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns Open
Early identification of altered brain networks in neonates at risk for neurodevelopmental impairments is critical for timely intervention and improving outcomes. This study explores the potential of graph neural networks (GNNs) applied to …
View article: Acceptability of immediate CPAP for preterm infants in the delivery room to mothers, caregivers and healthcare workers in a low-resource setting: a qualitative study
Acceptability of immediate CPAP for preterm infants in the delivery room to mothers, caregivers and healthcare workers in a low-resource setting: a qualitative study Open
Study is registered on Pan African Clinical Trials Registry (PACTR) PACTR202208462613789. Registered 08/08/2022. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=23888 .
View article: Psychological Well-Being in Adults Across the COVID-19 Pandemic: A Two-Year Longitudinal Study
Psychological Well-Being in Adults Across the COVID-19 Pandemic: A Two-Year Longitudinal Study Open
Objectives The COVID-19 pandemic significantly affected global psychological well-being. We explored long-term trajectories of adults’ well-being from before the pandemic through its progression and identified risk factors for compromised …
View article: CLIF-Net: Intersection-guided Cross-view Fusion Network for Infection Detection from Cranial Ultrasound
CLIF-Net: Intersection-guided Cross-view Fusion Network for Infection Detection from Cranial Ultrasound Open
This paper addresses the problem of detecting possible serious bacterial infection (pSBI) of infancy, i.e. a clinical presentation consistent with bacterial sepsis in newborn infants using cranial ultrasound (cUS) images. The captured imag…
View article: Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery—is there an association?
Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery—is there an association? Open
Background Patients with congenital heart disease (CHD) who are operated on after birth are at risk for neurodevelopmental (ND) impairment. Before birth, altered fetal hemodynamics due to the CHD may lead to reduced cerebral perfusion and …
View article: Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns
Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns Open
Early identification of altered brain networks in neonates at risk for neurodevelopmental impairments is critical for timely intervention and improving outcomes. This study explores the potential of graph convolutional networks (GCNs) appl…
View article: Executive function profiles in survivors of neonatal critical illness – a latent profile analysis in school-aged children born very preterm or with complex congenital heart disease and in typically developing peers
Executive function profiles in survivors of neonatal critical illness – a latent profile analysis in school-aged children born very preterm or with complex congenital heart disease and in typically developing peers Open
Executive function (EF) impairments are prevalent in survivors of neonatal critical illness such as children born very preterm (VPT) or with complex congenital heart disease (cCHD). This paper aimed to describe EF profiles in school-aged c…
View article: Redirection of Care for Neonates with Hypoxic-Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Redirection of Care for Neonates with Hypoxic-Ischemic Encephalopathy Receiving Therapeutic Hypothermia Open
Background/Objectives: Hypoxic-ischemic encephalopathy (HIE) in late preterm and term neonates accounts for neonatal mortality and unfavorable neurodevelopmental outcomes in survivors despite therapeutic hypothermia (TH) for neuroprotectio…
View article: Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross‐Etiologic Study
Altered Connectome Topology in Newborns at Risk for Cognitive Developmental Delay: A Cross‐Etiologic Study Open
The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) co…
View article: Prematurity is associated with white matter T2 MRI visible perivascular spaces in very preterm-born neonates
Prematurity is associated with white matter T2 MRI visible perivascular spaces in very preterm-born neonates Open
Perivascular spaces (PVSs), as biomarkers of the brain’s neurofluid clearance system, remain largely unexplored in the brains of very preterm and term-born infants. In this retrospective cross-sectional study, we investigate PVSs in very p…
View article: Redirection of Care for Neonates with Hypoxic-Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Redirection of Care for Neonates with Hypoxic-Ischemic Encephalopathy Receiving Therapeutic Hypothermia Open
Background/Objectives: Hypoxic-ischemic encephalopathy (HIE) in (near)term neonates accounts for neonatal mortality and unfavorable neurodevelopmental outcome in survivors, despite therapeutic hypothermia (TH) for neuroprotection. The circ…
View article: Web-based training and certification of clinical staff during the randomised clinical trial SafeBoosC-III
Web-based training and certification of clinical staff during the randomised clinical trial SafeBoosC-III Open
Background SafeBoosC-III is a pragmatic, multinational clinical trial evaluating cerebral oximetry-guided treatment for extremely preterm infants. In total, 1601 infants were randomised across 70 sites in Asia, Europe, and USA. To enhance …
View article: Impact of early continuous positive airway pressure in the delivery room (DR-CPAP) on neonates < 1500 g in a low-resource setting: a protocol for a pilot feasibility and acceptability randomized controlled trial
Impact of early continuous positive airway pressure in the delivery room (DR-CPAP) on neonates < 1500 g in a low-resource setting: a protocol for a pilot feasibility and acceptability randomized controlled trial Open
The study is registered on the Pan African Clinical Trials Registry (PACTR) PACTR202208462613789. Registered 08 August 2022. https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=23888 .
View article: Elevated cerebral perfusion in neonatal encephalopathy is associated with neurodevelopmental impairments
Elevated cerebral perfusion in neonatal encephalopathy is associated with neurodevelopmental impairments Open
View article: Early High-Dose Erythropoietin and Cognitive Functions of School-Aged Children Born Very Preterm
Early High-Dose Erythropoietin and Cognitive Functions of School-Aged Children Born Very Preterm Open
Importance Children born very preterm are at risk for long-term neurodevelopmental sequelae. Prophylactic high-dose recombinant human erythropoietin (rhEpo) shortly after birth has not been shown to improve cognitive, motor, and behavioral…
View article: Developmental trajectory of thalamus topography during the late preterm and perinatal period in normal development, after premature birth and in congenital heart defects
Developmental trajectory of thalamus topography during the late preterm and perinatal period in normal development, after premature birth and in congenital heart defects Open
The thalamus plays a critical role in neural circuit maturation and brain connectivity. It is well known to show a characteristic topographical organization of local and long-range connectivity, yet developmental changes in this topography…
View article: The Effect of High-Dose Erythropoietin Perinatally on Retinal Function in School-Aged Children Born Extremely or Very Preterm
The Effect of High-Dose Erythropoietin Perinatally on Retinal Function in School-Aged Children Born Extremely or Very Preterm Open
View article: Altered connectome topology in newborns at risk for cognitive developmental delay: a cross-etiologic study
Altered connectome topology in newborns at risk for cognitive developmental delay: a cross-etiologic study Open
The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) co…
View article: Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children
Inhibition abilities and functional brain connectivity in school-aged term-born and preterm-born children Open
View article: Sleep‐disordered breathing on respiratory polygraphy in neonates with spina bifida
Sleep‐disordered breathing on respiratory polygraphy in neonates with spina bifida Open
Introduction Studies have shown a high prevalence of sleep‐disordered breathing (SDB) in children with spina bifida. International standards for regular testing for SDB in this population are lacking. While there are studies investigating …
View article: The Effect of Perinatal High‐Dose Erythropoietin on Retinal Structural and Vascular Characteristics in Children Born Preterm
The Effect of Perinatal High‐Dose Erythropoietin on Retinal Structural and Vascular Characteristics in Children Born Preterm Open
Purpose: To study the long-term effects of perinatal high-dose recombinant human erythropoietin (rhEPO) on macular structural and vascular development in preterm children. Design: Randomized, double-blind clinical trial follow-up plus coho…
View article: Morbidity and mortality in premature or low birth weight patients with congenital heart disease in three European pediatric heart centers between 2016 and 2020
Morbidity and mortality in premature or low birth weight patients with congenital heart disease in three European pediatric heart centers between 2016 and 2020 Open
Background The treatment of preterm and low birth weight (LBW) neonates born with congenital heart disease (CHD) requiring early cardiac intervention remains challenging. We aimed to analyze morbidity and mortality in this combined high-ri…
View article: Alternative consent methods used in the multinational, pragmatic, randomised clinical trial SafeBoosC-III
Alternative consent methods used in the multinational, pragmatic, randomised clinical trial SafeBoosC-III Open
View article: Effects of hemodynamic alterations and oxygen saturation on cerebral perfusion in congenital heart disease
Effects of hemodynamic alterations and oxygen saturation on cerebral perfusion in congenital heart disease Open
View article: Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)
Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III) Open
Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Addit…
View article: Cerebral perfusion differences are linked to executive function performance in very preterm-born children and adolescents
Cerebral perfusion differences are linked to executive function performance in very preterm-born children and adolescents Open
Children and adolescents born very preterm are at risk of cognitive impairment, particularly affecting executive functions. To date, the neural correlates of these cognitive differences are not yet fully understood, although converging evi…
View article: Perioperative Brain Injury in Relation to Early Neurodevelopment Among Children with Severe Congenital Heart Disease: Results from a European Collaboration
Perioperative Brain Injury in Relation to Early Neurodevelopment Among Children with Severe Congenital Heart Disease: Results from a European Collaboration Open
View article: Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years
Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years Open
Spina bifida affects spinal cord and cerebral development, leading to motor and cognitive delay. We investigated whether there are associations between thalamocortical connectivity topography, neurological function, and developmental outco…
View article: Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants
Detailed statistical analysis plan for a secondary Bayesian analysis of the SafeBoosC-III trial: a multinational, randomised clinical trial assessing treatment guided by cerebral oximetry monitoring versus usual care in extremely preterm infants Open
View article: The effects of cerebral oximetry in mechanically ventilated newborns: a protocol for the SafeBoosC-IIIv randomised clinical trial
The effects of cerebral oximetry in mechanically ventilated newborns: a protocol for the SafeBoosC-IIIv randomised clinical trial Open