Cornelia M. Keck
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Silymarin PlantCrystals for Improved Dermal Drug Delivery Open
Background/Objectives: PlantCrystals (PCs) are submicron particles derived from plants or parts of plants that can be produced by bead milling and/or high-pressure homogenization. Previous studies suggested improved dermal drug delivery of…
View article: Enhanced follicular penetration of antiseptics using nanocrystals – investigated via novel hair follicle content removal method
Enhanced follicular penetration of antiseptics using nanocrystals – investigated via novel hair follicle content removal method Open
Effective skin disinfection is critical in preventing surgical-site infections (SSIs), particularly during long surgical procedures where bacteria from hair follicles can continuously emerge onto the skin surface and recolonize it. To enha…
View article: A pilot study on the cutaneous effects of ethanol in a moisturizing cream on non-lesional skin of patients with atopic dermatitis
A pilot study on the cutaneous effects of ethanol in a moisturizing cream on non-lesional skin of patients with atopic dermatitis Open
Ethanol is widely used in cosmetic formulations as a solvent, preservative, and penetration enhancer, yet its effects on atopic skin remain controversial. This study explores the impact of ethanol in skin care products on skin physiology, …
Smart-AMPs: Decorated Nanostructured Lipid Carriers for Improved Efficacy of Antimicrobial Peptides in Chronically Infected Burn Wounds Open
Background/Objectives: Burn wound infections present significant clinical challenges due to multidrug-resistant pathogens and the limitations of traditional antimicrobials. While antimicrobial peptides (AMPs) have broad-spectrum effectiven…
Challenges, Unmet Needs, and Future Directions for Nanocrystals in Dermal Drug Delivery Open
Nanocrystals, defined as crystalline particles with dimensions in the nanometer range (<1000 nm), exhibit unique properties that enhance the efficacy of poorly soluble active compounds. This review explores the fundamental aspects of nanoc…
View article: Influence of tear fluid properties on physicochemical, mucoadhesion and ocular penetration characteristics of transfersomes
Influence of tear fluid properties on physicochemical, mucoadhesion and ocular penetration characteristics of transfersomes Open
Due to changes in the tear fluid properties in dry eye disease (DED), eye drop performance may be altered. This study investigated the impact of tear fluid properties on the physicochemical, mucoadhesion and ocular penetration characterist…
Curcumin Microemulsions: Influence of Compositions on the Dermal Penetration Efficacy Open
Background/Objective: This study provided a comparison of the influence of each component of the microemulsion formulation and investigated the impact of varying concentrations of the microemulsion components on curcumin’s ability to penet…
Influence of Ethanol as a Preservative in Topical Formulation on the Dermal Penetration Efficacy of Active Compounds in Healthy and Barrier-Disrupted Skin Open
(1) Background: Ethanol is a multifunctional excipient often used as a preservative in topical formulations. Due to its known ability to impair skin barrier function, this study investigated the effect of ethanol (EtOH) as a preservative i…
Microneedle-Assisted Delivery of Curcumin: Evaluating the Effects of Needle Length and Formulation Open
Dermal drug delivery presents a significant challenge for poorly soluble active compounds like curcumin, which often struggle to penetrate the skin barrier effectively. In this study, the dermal penetration efficacy of curcumin nanocrystal…
Easy to use particle-mediated transport of various dissolved active agents into the hair follicles – A novel platform technology Open
The use of nanoparticulate systems for the transport of active ingredients into hair follicles has been researched for almost two decades, resulting in countless publications with a wide variety of particle types, release mechanisms and ac…
Extracellular Vesicles and PlantCrystals for Improved Bioavailability of Curcumin as a BCS Class IV Drug Open
The limited water solubility of active compounds remains a significant challenge for efficient dermal drug delivery, particularly for BCS class IV drugs such as curcumin. This study aimed to enhance curcumin’s dermal penetration using two …
Development of transferosomes for topical ocular drug delivery of curcumin Open
TFS offer a promising platform for ocular delivery of hydrophobic drugs. This study, for the first time, elucidates the effect of tissue morphology and osmotic gradients on drug penetration in different ocular tissues.
Utilizing an Ex Vivo Skin Penetration Analysis Model for Predicting Ocular Drug Penetration: A Feasibility Study with Curcumin Formulations Open
Objective: This study aimed to investigate the feasibility of using the digital image processing technique, developed to semi-quantitatively study dermal penetration, to study corneal penetration in an ex vivo porcine eye model. Here, we i…
The penetration efficiency of a dissolved model drug into hair follicles depends on the concentration of added nanoparticles Open
Hair follicles have recently emerged as promising drug delivery targets and gates for skin penetration. The so-called ratchet effect, which is based on an interaction between the hair shaft surface, the intrafollicular stratum corneum and …
Metabolipidomic changes induced by dermal nickel penetration determined in an ex vivo porcine ear skin model Open
Rational Nickel is one of humans' most prevalent triggers of allergic contact dermatitis. However, the underlying mechanisms of this allergy still need to be fully understood. One aspect that has yet to be explored is the direct impact of …
Influence of type of vehicle on dermal penetration efficacy of hydrophilic, amphiphilic, lipophilic model drugs Open
The influence of the vehicle on the dermal penetration efficacy of three different active ingredient (AI) surrogates (hydrophilic, amphiphilic, lipophilic model drugs), that were incorporated into these vehicles, was investigated with the …
Influence of Dose, Particle Size and Concentration on Dermal Penetration Efficacy of Curcumin Open
The influence of size, particle concentration and applied dose (finite vs. infinite dose) on the dermal penetration efficacy of curcumin was investigated in this study. For this, curcumin suspensions with different particle sizes (approx. …
Influence of Dose, Particle Size &Amp; Concentration on Dermal Penetration Efficacy of Curcumin Open
Dermal penetration is considered to mainly occur via passive diffusion. Therefore, a high concentration gradient of dissolved active ingredient between formulation and skin is needed to achieve an effective dermal penetration. The concentr…
Natural dispersion of biflavonoids from Garcinia madruno extracts: A green and sustainable processing to improve the solubility and dissolution rate Open
Garcinia madruno is rich in antioxidant biflavonoids that could be used to treat oxidative-related diseases. Up to now, its commercial application is challenging due to the poor water solubility of biflavonoids. This work aimed to develop …
View article: <scp>Far‐UVC</scp>‐ and <scp>UVB</scp>‐induced <scp>DNA</scp> damage depending on skin type
<span>Far‐UVC</span>‐ and <span>UVB</span>‐induced <span>DNA</span> damage depending on skin type Open
Far‐UVC radiation sources of wavelengths 222 nm and 233 nm represent an interesting potential alternative for the antiseptic treatment of the skin due to their high skin compatibility. Nevertheless, no studies on far‐UVC‐induced DNA damage…
View article: Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation
Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation Open
(1) Background: Amorphous drug systems are an intensively studied approach to overcome the insufficient bioavailability of poorly soluble drugs. Here, paper tablets were studied, which were made from cellulose-based paper matrices loaded w…
Production of Hydrogel-Based Curcumin-Loaded O/W Suspoemulsions Open
Curcumin is a biopharmaceutical classification system (BCS) class IV substance with many potential therapeutic effects. However, like many other BCS IV active pharmaceutical ingredients, complex formulations are needed to guarantee a suffi…
View article: Advanced Skin Antisepsis: Application of UVA-Cleavable Hydroxyethyl Starch Nanocapsules for Improved Eradication of Hair Follicle-Associated Microorganisms
Advanced Skin Antisepsis: Application of UVA-Cleavable Hydroxyethyl Starch Nanocapsules for Improved Eradication of Hair Follicle-Associated Microorganisms Open
Hair follicles constitute important drug delivery targets for skin antisepsis since they contain ≈25% of the skin microbiome. Nanoparticles are known to penetrate deeply into hair follicles. By massaging the skin, the follicular penetratio…
Improving the Bioactivity of Norfloxacin with Tablets Made from Paper Open
(1) Background: Many drugs possess poor bioavailability, and many strategies are available to overcome this issue. In this study, smartFilm technology, i.e., a porous cellulose matrix (paper), in which the active compound can be loaded ont…
Methodology to Reach Full Spectral Photo-Protection by Selecting the Best Combination of Physical Filters and Antioxidants Open
Antioxidants can reduce free radical formation in deeper skin layers where typical sunscreen filters may no longer be effective. Here, a general method is presented to pre-select optimum combinations of antioxidants and physical filters. T…
Tablets Made from Paper—An Industrially Feasible Approach Open
Many orally administrated drugs exhibit poor bioavailability due to their limited solubility. The smartFilm technology is an innovative approach to improve the drug aqueous solubility, where the drug is embedded within the matrix of cellul…
SmartFilm Tablets for Improved Oral Delivery of Poorly Soluble Drugs Open
(1) Background: Numerous oral drugs exhibit limited bioavailability due to their poor solubility and poor intestinal permeability. The smartFilm technology is an innovative approach that improves the drug aqueous solubility via incorporati…
Influence of Mechanical Skin Treatments on Dermal Penetration Efficacy of Active Ingredients Open
The effective dermal penetration of active ingredients (AI) is a major task in the formulation of topical products. Besides the vehicle, the mechanical skin treatments are also considered to impact the penetration efficacy of AI. In partic…