Cornelia Leo
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View article: Retained Lead Fragments in Superior Vena Cava and Early Post-Transplant Outcomes: A Single Center Preliminary Retrospective Study
Retained Lead Fragments in Superior Vena Cava and Early Post-Transplant Outcomes: A Single Center Preliminary Retrospective Study Open
Background/Objectives: Retained fragments of cardiovascular implantable electronic device (CIED) leads are frequently observed after orthotopic heart transplantation (OHT), but their clinical relevance remains unclear. Methods: We conducte…
View article: Pulse-Echo Imaging of Breast Speed of Sound as a Potential Biomarker for Breast Cancer
Pulse-Echo Imaging of Breast Speed of Sound as a Potential Biomarker for Breast Cancer Open
This study highlights the feasibility of SoS contrast as an imaging biomarker for the differential diagnosis of breast lesions. It also indicates the need for further technical advancements in SoS imaging to strengthen its ability to effec…
View article: Case Report: Cardiac transplantation in a 76-year-old recipient: moving from anagraphic to biological age under a geriatric perspective
Case Report: Cardiac transplantation in a 76-year-old recipient: moving from anagraphic to biological age under a geriatric perspective Open
Background/objectives Heart transplantation remains the definitive treatment for end-stage heart failure. However, donor shortages and the increasing age of candidates present significant challenges. This report aims to highlight the feasi…
View article: Surgical MArker Localization OR clip and wire application for targeted axillary dissection in node-positive breast cancer patients – Results from the randomized superiority MALLORCA-trial
Surgical MArker Localization OR clip and wire application for targeted axillary dissection in node-positive breast cancer patients – Results from the randomized superiority MALLORCA-trial Open
Magnetic surgical markers showed clear advantages for TAD after NAT in procedural efficiency, reliability, and intraoperative handling compared to gel-embedded clips. Marker selection should consider technical, procedural, and imaging-rela…
View article: Artificial Intelligence Language Models to Translate Professional Radiology Mammography Reports Into Plain Language – Impact on Interpretability and Perception by Patients
Artificial Intelligence Language Models to Translate Professional Radiology Mammography Reports Into Plain Language – Impact on Interpretability and Perception by Patients Open
Patient preference differed among AI-translated radiology reports. Compared to a traditional report using radiological language, AI-translated reports add value for patients, enhance comprehensibility and empathy and therefore hold the pot…
View article: Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue
Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue Open
Extracellular matrix (ECM) remodeling plays critical roles in cancer progression and involves alterations in its composition and biophysical properties. Aggressiveness and malignancy of solid tumors are strongly correlated with tissue stif…
View article: The LYMPH trial: comparing microsurgical with conservative treatment for chronic breast cancer-associated lymphoedema – study protocol of a pragmatic randomised international multicentre superiority trial
The LYMPH trial: comparing microsurgical with conservative treatment for chronic breast cancer-associated lymphoedema – study protocol of a pragmatic randomised international multicentre superiority trial Open
Introduction Up to one-fifth of breast cancer survivors will develop chronic breast cancer-related lymphoedema (BCRL). To date, complex physical decongestion therapy (CDT) is the gold standard of treatment. However, it is mainly symptomati…
View article: Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study
Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study Open
PURPOSE The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management is not standardized. We investigated rates …
View article: The LYMPH Trial - Comparing Microsurgical with Conservative Treatment of Chronic Breast Cancer Associated Lymphedema: Study Protocol of a Pragmatic Randomized International Multicentre Superiority Trial
The LYMPH Trial - Comparing Microsurgical with Conservative Treatment of Chronic Breast Cancer Associated Lymphedema: Study Protocol of a Pragmatic Randomized International Multicentre Superiority Trial Open
Introduction Up to one fifth of breast cancer survivors will develop chronic breast cancer-related lymphedema (BCRL). To date complex physical decongestion therapy (CDT) is the gold standard of treatment. However, it is mainly symptomatic …
View article: Routine Genetic Testing of Germline Breast Cancer Susceptibility ─ Challenges and Opportunities
Routine Genetic Testing of Germline Breast Cancer Susceptibility ─ Challenges and Opportunities Open
Information on germline BRCA (g*BRCA*) 1/2 pathogenic or likely pathogenic mutations has predictive value for response to platinating agents and poly(ADP-ribose) polymerase inhibitors (PARPi) and survival outcomes of breast cancer (BC) pat…
View article: Long-Term Follow-Up of High-Risk Breast Lesions at Vacuum-Assisted Biopsy without Subsequent Surgical Resection
Long-Term Follow-Up of High-Risk Breast Lesions at Vacuum-Assisted Biopsy without Subsequent Surgical Resection Open
Introduction: B3-lesions of the breast are a heterogeneous group of neoplasms, associated with a higher risk of breast cancer. Recent studies show a low upgrade rate into malignancy after subsequent open surgical excision (OE) of most B3-l…
View article: Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer
Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer Open
Importance The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)–positive breast cancer (BC) is currently unknown. Objective To address …
View article: Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101) Open
Purpose The aim of this study was to evaluate clinical practice heterogeneity in use of neoadjuvant systemic therapy (NST) for patients with clinically node-positive breast cancer in Europe. Methods The study was preplanned in the internat…
View article: Increased dose efficiency of breast CT with grating interferometry
Increased dose efficiency of breast CT with grating interferometry Open
Refraction-based x-ray imaging can overcome the fundamental contrast limit of computed tomography (CT), particularly in soft tissue, but so far has been constrained to high-dose ex vivo applications or required highly coherent x-ray source…
View article: Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) Open
The heterogeneous group of B3 lesions in the breast harbors lesions with different malignant potential and progression risk. As several studies about B3 lesions have been published since the last Consensus in 2018, the 3rd International Co…
View article: Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience
Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience Open
Trastuzumab and pertuzumab with taxane-based chemotherapy are considered the first-line standard therapy for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC). Pertuzumab is also a later-line therapy f…
View article: Supplementary Table 1 from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
Supplementary Table 1 from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia Open
Supplementary Table 1 from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
View article: Data from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
Data from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia Open
Hypoxia is now established as a key factor influencing the pathophysiology of malignant growth. Among other effects, hypoxia modulates the expression of a multitude of genes through the induction of hypoxia-inducible transcription factors.…
View article: Supplementary Table 1 from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
Supplementary Table 1 from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia Open
Supplementary Table 1 from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
View article: Data from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia
Data from Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia Open
Hypoxia is now established as a key factor influencing the pathophysiology of malignant growth. Among other effects, hypoxia modulates the expression of a multitude of genes through the induction of hypoxia-inducible transcription factors.…
View article: Refraction beats attenuation in breast CT
Refraction beats attenuation in breast CT Open
For a century, clinical X-ray imaging has visualised only the attenuation properties of tissue, which fundamentally limits the contrast, particularly in soft tissues like the breast. Imaging based on refraction can overcome this limitation…
View article: Regional analgesia with or without general anaesthesia for breast cancer surgery: a network meta-analysis
Regional analgesia with or without general anaesthesia for breast cancer surgery: a network meta-analysis Open
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess whether the analgesic efficacy and safety differ according to the regional analgesia technique used in women undergoing breast c…
View article: Pertuzumab As Second- or Later-Line Therapy For Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: A Swiss Clinical Experience
Pertuzumab As Second- or Later-Line Therapy For Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: A Swiss Clinical Experience Open
Background: Trastuzumab and pertuzumab with taxane-based chemotherapy are considered the first-line standard therapy for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC). Pertuzumab is also a later-li…