Cornelia Monzel
YOU?
Author Swipe
View article: Semisynthetic Ferritin Nanocages for Flexible, Site-Specific Targeting and Ligand-Free Activation of Membrane Receptors
Semisynthetic Ferritin Nanocages for Flexible, Site-Specific Targeting and Ligand-Free Activation of Membrane Receptors Open
Homopolymerization and cluster formation of cellular membrane receptors (MRs) are increasingly recognized as an essential facet of cell signaling and modulator of physiological responses. Yet, there is a lack of tools that can mediate prec…
View article: Diacetylene‐Functionalized Glycan Mimetics for Receptor‐Mediated Cluster Imprinting in Model Membranes
Diacetylene‐Functionalized Glycan Mimetics for Receptor‐Mediated Cluster Imprinting in Model Membranes Open
The glycocalyx, a dense layer of glycoproteins and glycolipids on eukaryotic cells, is essential for cellular functions such as communication, signaling, and pathogen interactions. Certain components spontaneously organize into membrane mi…
View article: Effects of DNA Origami‐Based Nanoagent Design on Apoptosis Induction in a Large 3D Cancer Spheroid Model
Effects of DNA Origami‐Based Nanoagent Design on Apoptosis Induction in a Large 3D Cancer Spheroid Model Open
DNA origami offers highly accurate control over shape and addressability on the nanoscale. This precise control makes it highly valuable in various fields, particularly precision nanotherapeutics. For cancer treatment, the extrinsic activa…
View article: Effects of DNA Origami-Based Nanoagent Design on Apoptosis Induction in a Large 3D Spheroid Model
Effects of DNA Origami-Based Nanoagent Design on Apoptosis Induction in a Large 3D Spheroid Model Open
The extrinsic activation of programmed cell death by FasR/CD95 is a promising minimally invasive strategy for cancer treatment. This can be leveraged using high-precision nanoscale therapeutics: Utilizing DNA origami for precise Fas ligand…
View article: Semisynthetic ferritin nanocages for flexible, site-specific targeting, cluster-formation and activation of membrane receptors
Semisynthetic ferritin nanocages for flexible, site-specific targeting, cluster-formation and activation of membrane receptors Open
Homopolymerization and cluster formation of cellular membrane receptors (MR) is closely related to their signaling activity. However, underlying mechanisms and effects of clustering are often hardly understood. This lack of knowledge is du…
View article: Selective Glycan Presentation in Liquid‐Ordered or ‐Disordered Membrane Phases and its Effect on Lectin Binding
Selective Glycan Presentation in Liquid‐Ordered or ‐Disordered Membrane Phases and its Effect on Lectin Binding Open
Glycan‐protein interactions play a key role in various biological processes from fertilization to infections. Many of these interactions take place at the glycocalyx—a heavily glycosylated layer at the cell surface. Despite its significanc…
View article: Selective Glycan Presentation in Liquid‐Ordered or ‐Disordered Membrane Phases and its Effect on Lectin Binding
Selective Glycan Presentation in Liquid‐Ordered or ‐Disordered Membrane Phases and its Effect on Lectin Binding Open
Glycan‐protein interactions play a key role in various biological processes from fertilization to infections. Many of these interactions take place at the glycocalyx—a heavily glycosylated layer at the cell surface. Despite its significanc…
View article: High yield purification of an Isoleucine zipper modified CD95 Ligand with either biotin or DNA-oligomer binding domain for efficient Cell Apoptosis Induction
High yield purification of an Isoleucine zipper modified CD95 Ligand with either biotin or DNA-oligomer binding domain for efficient Cell Apoptosis Induction Open
Background Cluster of differentiation 95 (CD95/Fas/Apo1) as part of the Tumor-necrosis factor (TNF) receptor family is a prototypic trigger of the ‘extrinsic’ apoptotic pathway and its activation by the trimeric ligand CD95L is of high int…
View article: Mobile and Immobile Obstacles in Supported Lipid Bilayer Systems and Their Effect on Lipid Mobility
Mobile and Immobile Obstacles in Supported Lipid Bilayer Systems and Their Effect on Lipid Mobility Open
Diffusion and immobilization of molecules in biomembranes are essential for life. Understanding it is crucial for biomimetic approaches where well-defined substrates are created for live cell assays or biomaterial development. Here, we pre…
View article: Advanced multiparametric image spectroscopy and super-resolution microscopy reveal a minimal model of CD95 signal initiation
Advanced multiparametric image spectroscopy and super-resolution microscopy reveal a minimal model of CD95 signal initiation Open
Unraveling the concentration-dependent spatiotemporal organization of receptors in the plasma membrane is crucial to understand cell signal initiation. A paradigm of this process is the oligomerization of CD95 during apoptosis signaling, w…
View article: Semisynthetic ferritin-based nanoparticles with high magnetic anisotropy for spatial magnetic manipulation and inductive heating
Semisynthetic ferritin-based nanoparticles with high magnetic anisotropy for spatial magnetic manipulation and inductive heating Open
The core of the semi-synthetic magnetic nanoparticle magnetoferritin was doped with cobalt or zinc in order to evaluate its applicability as a nanoagent for intracellular target redistribution or localised heat dissipation via magnetic hyp…
View article: An efficient magnetothermal actuation setup for fast heating/cooling cycles or long-term induction heating of different magnetic nanoparticle classes
An efficient magnetothermal actuation setup for fast heating/cooling cycles or long-term induction heating of different magnetic nanoparticle classes Open
Alternating magnetic fields (AMFs) in the ∼100 kHz frequency regime cause magnetic nanoparticles (MNPs) to dissipate heat to their nanoscale environment. This mechanism is beneficial for a variety of applications in biomedicine and nanotec…
View article: Detection of Lectin Clustering in Self‐Assembled, Glycan‐Functionalized Amphiphiles by Aggregation‐Induced Emission Luminophores
Detection of Lectin Clustering in Self‐Assembled, Glycan‐Functionalized Amphiphiles by Aggregation‐Induced Emission Luminophores Open
Amphiphilic glycan‐functionalized oligomers are derived by solid‐phase polymer synthesis and applied in both, self‐assembled micelles as well as giant unilamellar vesicles, as simplified models of the cell's glycocalyx. Additionally, an ag…
View article: First-Principle Coarse-Graining Framework for Scale-Free Bell-Like Association and Dissociation Rates in Thermal and Active Systems
First-Principle Coarse-Graining Framework for Scale-Free Bell-Like Association and Dissociation Rates in Thermal and Active Systems Open
Fluctuations of surfaces that harbor reactive molecules interacting across the intervening space strongly influence the reaction kinetics. One such paradigmatic system is the cell membrane, with associated proteins, binding to an interior …
View article: Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies
Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies Open
The great clinical success of chimeric antigen receptor (CAR) T cells has unlocked new levels of immunotherapy for hematological malignancies. Genetically modifying natural killer (NK) cells as alternative CAR immune effector cells is also…
View article: Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells
Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells Open
Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force respons…
View article: An experimental platform for studying the radiation effects of laser accelerated protons on mammalian cells
An experimental platform for studying the radiation effects of laser accelerated protons on mammalian cells Open
An experimental platform was designed to study the effects of laser accelerated protons (LAPs) on mammalian cells. The protons, in the MeV energy range, originate from the rear side of a thin 5 µm Ti foil target following the interaction w…
View article: Nanoscale FasL Organization on DNA Origami to Decipher Apoptosis Signal Activation in Cells
Nanoscale FasL Organization on DNA Origami to Decipher Apoptosis Signal Activation in Cells Open
Cell signaling is initiated by characteristic protein patterns in the plasma membrane, but tools to decipher their molecular organization and activation are hitherto lacking. Among the well‐known signaling pattern is the death inducing sig…
View article: Fluorescence Correlation Spectroscopy Reveals Interaction of Some Microdomain-Associated Lipids with Cellular Focal Adhesion Sites
Fluorescence Correlation Spectroscopy Reveals Interaction of Some Microdomain-Associated Lipids with Cellular Focal Adhesion Sites Open
Cells adhere to the extracellular matrix at distinct anchoring points, mostly focal adhesions. These are rich in immobile transmembrane- and cytoskeletal-associated proteins, some of which are known to interact with lipids of the plasma me…
View article: Single‐molecule analysis of dynamics and interactions of the SecYEG translocon
Single‐molecule analysis of dynamics and interactions of the SecYEG translocon Open
Protein translocation and insertion into the bacterial cytoplasmic membrane are the essential processes mediated by the Sec machinery. The core machinery is composed of the membrane‐embedded translocon SecYEG that interacts with the secret…
View article: Nanoscale Organization of FasL on DNA Origami as a Versatile Platform to Tune Apoptosis Signaling in Cells
Nanoscale Organization of FasL on DNA Origami as a Versatile Platform to Tune Apoptosis Signaling in Cells Open
Nanoscale probes with fine-tunable properties are of key interest in cell biology and nanomedicine to elucidate and eventually control signaling processes in cells. A critical, still challenging issue is to conjugate these probes with mole…
View article: Autonomous induction of hepatic polarity to construct single cell liver
Autonomous induction of hepatic polarity to construct single cell liver Open
Symmetry breaking of protein distribution and cytoskeleton organization is an essential aspect for development of apico-basal polarity. In embryonic cells this process is largely cell autonomous, while differentiated epithelial cells colle…
View article: Simple Physical Model Unravels Influences of Chemokine on Shape Deformation and Migration of Human Hematopoietic Stem Cells
Simple Physical Model Unravels Influences of Chemokine on Shape Deformation and Migration of Human Hematopoietic Stem Cells Open
We studied the dynamic behavior of human hematopoietic stem cells (HSC) on the in vitro model of bone marrow surfaces in the absence and presence of chemokine (SDF1 α ). The deformation and migration of cells were investigated by varying t…
View article: Author Correction: Dynamic cellular phenotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents
Author Correction: Dynamic cellular phenotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
View article: Cell-cell contact dictates life or death decisions following CD95 activation in cancer
Cell-cell contact dictates life or death decisions following CD95 activation in cancer Open
Cancer cells react to CD95 activation with either apoptotic or tumorigenic responses. Yet, the determinants of these two antithetic reactions are fundamentally not understood. Here, we show that pre-confined CD95L molecules activate apopto…