Cornelia Speth
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View article: Inhalation of N-chlorotaurine is an effective treatment of Aspergillus fumigatus pneumonia in mice
Inhalation of N-chlorotaurine is an effective treatment of Aspergillus fumigatus pneumonia in mice Open
Introduction: N-chlorotaurine (NCT), a long-lived oxidant of human granulocytes, can be used topically as anti-infective in different body regions. The aim of the present study was to demonstrate the efficacy and tolerability of inhaled NC…
View article: Heterologous combinations of VSV-GP and native-like trimers elicit autologous Tier 2 HIV antibodies in rabbits
Heterologous combinations of VSV-GP and native-like trimers elicit autologous Tier 2 HIV antibodies in rabbits Open
Developing an effective human immunodeficiency virus (HIV) vaccine remains challenging due to difficulties to induce antibodies that neutralize the wide range of HIV-variants. Native-like HIV envelope (Env) trimers in a closed conformation…
View article: Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo
Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo Open
Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the …
View article: Complement and Fungal Dysbiosis as Prognostic Markers and Potential Targets in PDAC Treatment
Complement and Fungal Dysbiosis as Prognostic Markers and Potential Targets in PDAC Treatment Open
Pancreatic ductal adenocarcinoma (PDAC) is still hampered by a dismal prognosis. A better understanding of the tumor microenvironment within the pancreas and of the factors affecting its composition is of utmost importance for developing n…
View article: Indications that the Antimycotic Drug Amphotericin B Enhances the Impact of Platelets on Aspergillus
Indications that the Antimycotic Drug Amphotericin B Enhances the Impact of Platelets on Aspergillus Open
Platelets are currently thought to harbor antimicrobial functions and might therefore play a crucial role in infections, e.g., those caused by Aspergillus or mucormycetes. The incidence of invasive fungal infections is increasing, particul…
View article: Efficacy of Inhaled N-Chlorotaurine in a Mouse Model of Lichtheimia corymbifera and Aspergillus fumigatus Pneumonia
Efficacy of Inhaled N-Chlorotaurine in a Mouse Model of Lichtheimia corymbifera and Aspergillus fumigatus Pneumonia Open
N-chlorotaurine (NCT) can be used topically as a well-tolerated anti-infective at different body sites. The aim of this study was to investigate the efficacy of inhaled NCT in a mouse model of fungal pneumonia. Specific pathogen-free femal…
View article: Influence of Glucose on Candida albicans and the Relevance of the Complement FH-Binding Molecule Hgt1 in a Murine Model of Candidiasis
Influence of Glucose on Candida albicans and the Relevance of the Complement FH-Binding Molecule Hgt1 in a Murine Model of Candidiasis Open
Candidiasis is common in diabetic patients. Complement evasion is facilitated by binding complement factor H (FH). Since the expression of high-affinity glucose transporter 1 (Hgt1), a FH-binding molecule, is glucose-dependent, we aimed to…
View article: Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth Open
Over the last decade, communication between immune cells by extracellular vesicle-associated miRNAs has emerged as an important regulator of the coordinated immune response. Therefore, a thorough understanding of the conversation occurring…
View article: Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections
Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections Open
Overactivation of the complement system has been characterized in severe COVID-19 cases. Complement components are known to trigger NETosis via the coagulation cascade and have also been reported in human tracheobronchial epithelial cells.…
View article: Micro- and Mycobiota Dysbiosis in Pancreatic Ductal Adenocarcinoma Development
Micro- and Mycobiota Dysbiosis in Pancreatic Ductal Adenocarcinoma Development Open
Background: Dysbiosis of the intestinal flora has emerged as an oncogenic contributor in different malignancies. Recent findings suggest a crucial tumor-promoting role of micro- and mycobiome alterations also in the development of pancreat…
View article: Significant Differences in Host-Pathogen Interactions Between Murine and Human Whole Blood
Significant Differences in Host-Pathogen Interactions Between Murine and Human Whole Blood Open
Murine infection models are widely used to study systemic candidiasis caused by C. albicans . Whole-blood models can help to elucidate host-pathogens interactions and have been used for several Candida species in human blood. We adapted th…
View article: Aspergillus-Derived Galactosaminogalactan Triggers Complement Activation on Human Platelets
Aspergillus-Derived Galactosaminogalactan Triggers Complement Activation on Human Platelets Open
Invasive fungal infections caused by Aspergillus (A.) and Mucorales species still represent life-threatening diseases in immunocompromised individuals, and deeper knowledge about fungal interactions with elements of innate immunity, such a…
View article: Candida and Complement: New Aspects in an Old Battle
Candida and Complement: New Aspects in an Old Battle Open
Candida is a dominant fungal pathogen in immunocompromised hosts, leading to opportunistic infections. Complement with its multifaceted functions is involved in the immune defense against this yeast, and recently several novel aspects have…
View article: Comparative immunopathogenesis in a murine model of inhalative infection with the mucormycetes Lichtheimia corymbifera and Rhizopus arrhizus
Comparative immunopathogenesis in a murine model of inhalative infection with the mucormycetes Lichtheimia corymbifera and Rhizopus arrhizus Open
Pathogenic mucormycetes induce diseases with considerable morbidity and mortality in immunocompromised patients. Virulence data comparing different Mucorales species and various underlying risk factors are limited. We therefore compared th…
View article: Evaluation of a Novel Mitochondrial Pan-Mucorales Marker for the Detection, Identification, Quantification, and Growth Stage Determination of Mucormycetes
Evaluation of a Novel Mitochondrial Pan-Mucorales Marker for the Detection, Identification, Quantification, and Growth Stage Determination of Mucormycetes Open
Mucormycosis infections are infrequent yet aggressive and serious fungal infections. Early diagnosis of mucormycosis and its discrimination from other fungal infections is required for targeted treatment and more favorable patient outcomes…
View article: Candida albicans Factor H Binding Molecule Hgt1p – A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils
Candida albicans Factor H Binding Molecule Hgt1p – A Low Glucose-Induced Transmembrane Protein Is Trafficked to the Cell Wall and Impairs Phagocytosis and Killing by Human Neutrophils Open
Complement is a tightly controlled arm of the innate immune system, facilitating phagocytosis and killing of invading pathogens. Factor H (FH) is the main fluid-phase inhibitor of the alternative pathway. Many pathogens can hijack FH from …
View article: Galactosaminogalactan (GAG) and its multiple roles in <i>Aspergillus</i> pathogenesis
Galactosaminogalactan (GAG) and its multiple roles in <i>Aspergillus</i> pathogenesis Open
Aspergillus spp and particularly the species Aspergillus fumigatus are the causative agents of invasive aspergillosis, a progressive necrotizing pneumonia that occurs in immunocompromised patients. The limited efficacy of currently availab…
View article: The structure of the Shiga toxin 2a A‐subunit dictates the interactions of the toxin with blood components
The structure of the Shiga toxin 2a A‐subunit dictates the interactions of the toxin with blood components Open
Hemolytic uremic syndrome (eHUS) is a severe complication of human infections with Shiga toxins (Stxs)-producing Escherichia coli. A key step in the pathogenesis of eHUS is the interaction of Stxs with blood components before the targeting…
View article: Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex
Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex Open
Although neglected in the past, the interest on Zika virus (ZIKV) raised dramatically in the last several years. The rapid spread of the virus in Latin America and the association of the infection with microcephaly in newborns or Guillain-…
View article: <b><i>Candida</i></b>: Platelet Interaction and Platelet Activity in vitro
<b><i>Candida</i></b>: Platelet Interaction and Platelet Activity in vitro Open
Over the last 2 decades, platelets have been recognized as versatile players of innate immunity. The interaction of platelets with fungal pathogens and subsequent processes may critically influence the clinical outcome of invasive mycoses.…
View article: Ketoacidosis alone does not predispose to mucormycosis by<i>Lichtheimia</i>in a murine pulmonary infection model
Ketoacidosis alone does not predispose to mucormycosis by<i>Lichtheimia</i>in a murine pulmonary infection model Open
Mucormycosis is a rare fungal infection; however, the number of cases increased during the last decades. The main risk factors are immunosuppression and uncontrolled diabetes mellitus. Although Lichtheimia species represent a common cause …