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View article: Halting Hypercaloric Feeding in Liver Chimeric Mice Rapidly Resolves Human Hepatocyte Steatosis
Halting Hypercaloric Feeding in Liver Chimeric Mice Rapidly Resolves Human Hepatocyte Steatosis Open
PNPLA3 3 148-isoleucine variant human hepatocytes in chimeric mice rapidly resolve steatosis with a gradual improvement in steatohepatitis activity, which is delayed in PNPLA3-148M hepatocytes. This supports a model in which altered lipid …
View article: Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection
Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection Open
Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increas…
View article: An RNA-based system to study hepatitis B virus replication and evaluate antivirals
An RNA-based system to study hepatitis B virus replication and evaluate antivirals Open
Hepatitis B virus (HBV) chronically infects an estimated 300 million people, and standard treatments are rarely curative. Infection increases the risk of liver cirrhosis and hepatocellular carcinoma, and consequently, nearly 1 million peop…
View article: Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model
Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model Open
Powassan virus (POWV) is an emerging tick-borne virus and cause of lethal encephalitis in humans. The lack of treatment or prevention strategies for POWV disease underscores the need for an effective POWV vaccine. Here, we took two indepen…
View article: Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice Open
View article: Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States
Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States Open
Background Hepatocellular carcinoma (HCC) patient‐derived xenograft (PDX) models hold potential to advance knowledge in HCC biology to help improve systemic therapies. Beside hepatitis B virus‐associated tumors, HCC is poorly established i…
View article: Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice Open
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase doma…
View article: Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice
Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice Open
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase doma…
View article: A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations Open
View article: Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice
Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice Open
View article: Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity
Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity Open
SUMMARY Although there is no effective cure for chronic hepatitis B virus (HBV) infection, antibodies are protective and constitute clinical correlates of recovery from infection. To examine the human neutralizing antibody response to HBV …
View article: Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes
Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes Open
Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, …
View article: Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes
Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes Open
© 2020 National Academy of Sciences. All rights reserved. Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resista…
View article: An RNA-based system to study hepatitis B virus replication and select drug-resistance mutations
An RNA-based system to study hepatitis B virus replication and select drug-resistance mutations Open
Hepatitis B virus (HBV) chronically infects over 250 million people worldwide, increasing their risk of liver cirrhosis and hepatocellular carcinoma. There is a vaccine to prevent new infections, but no efficient cure for chronic infection…
View article: Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids Open
View article: Intrinsic Immunity Shapes Viral Resistance of Stem Cells
Intrinsic Immunity Shapes Viral Resistance of Stem Cells Open
View article: Analysis of Hepatitis C Virus Particle Heterogeneity in Immunodeficient Human Liver Chimeric fah-/- Mice
Analysis of Hepatitis C Virus Particle Heterogeneity in Immunodeficient Human Liver Chimeric fah-/- Mice Open
View article: Mouse models of acute and chronic hepacivirus infection
Mouse models of acute and chronic hepacivirus infection Open
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impe…