Cortney Steele
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View article: Time-restricted eating and autosomal dominant polycystic kidney disease: a pilot, randomized clinical trial
Time-restricted eating and autosomal dominant polycystic kidney disease: a pilot, randomized clinical trial Open
Background Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited progressive kidney disease. Time-restricted eating (TRE) is a fasting regimen that restricts eating to a particular window (typically 8 hours/da…
View article: Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials
Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials Open
Background Tubular biomarkers, which reflect tubular dysfunction or injury, are associated with incident chronic kidney disease and kidney function decline. Several tubular biomarkers have also been implicated in the progression of autosom…
View article: Sodium Bicarbonate Treatment and Vascular Function in CKD: A Randomized, Double-Blind, Placebo-Controlled Trial
Sodium Bicarbonate Treatment and Vascular Function in CKD: A Randomized, Double-Blind, Placebo-Controlled Trial Open
Significance Statement Lower serum bicarbonate levels, even within the normal range, are strongly linked to risks of cardiovascular disease in CKD, possibly by modifying vascular function. In this randomized, controlled trial, treatment wi…
View article: Nonpharmacological Management of Autosomal Dominant Polycystic Kidney Disease
Nonpharmacological Management of Autosomal Dominant Polycystic Kidney Disease Open
View article: Table of Contents
Table of Contents Open
View article: Targeting Glycosphingolipid Metabolism in ADPKD: Another Roadblock for Treatment
Targeting Glycosphingolipid Metabolism in ADPKD: Another Roadblock for Treatment Open
View article: A Step Ahead toward Measuring Pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
A Step Ahead toward Measuring Pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Open
Pain is a frequent complication of autosomal dominant polycystic kidney disease (ADPKD), afflicting most patients,1 and is the most frequent symptom leading to a diagnosis of the disease.2 The most frequently reported types of pain are low…
View article: Cerebrovascular Pulsatility Index Is Reduced in Autosomal Dominant Polycystic Kidney Disease
Cerebrovascular Pulsatility Index Is Reduced in Autosomal Dominant Polycystic Kidney Disease Open
Introduction: Cerebrovascular dysfunction, characterized by increased brain pulsatile flow, reduced cerebrovascular reactivity, and cerebral hypoperfusion precedes the onset of dementia and is linked to cognitive dysfunction. Autosomal dom…
View article: Cerebrovascular pulsatility index is higher in chronic kidney disease
Cerebrovascular pulsatility index is higher in chronic kidney disease Open
Patients with chronic kidney disease (CKD) are more likely to die of cardiovascular diseases, including cerebrovascular disease, than to progress to end‐stage kidney disease. Cerebrovascular dysfunction, characterized by reduced cerebrovas…
View article: Sex hormones and the risk of cardiovascular disease and mortality in male and female patients with chronic kidney disease: A systematic review and meta‐analysis
Sex hormones and the risk of cardiovascular disease and mortality in male and female patients with chronic kidney disease: A systematic review and meta‐analysis Open
Patients with chronic kidney disease (CKD) commonly experience sex hormone disturbances, which may be associated with the risk of cardiovascular disease (CVD) and mortality. This review aimed to systematically evaluate current findings on …
View article: Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease
Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease Open
Obesity remains a growing public health concern in industrialized countries around the world. The prevalence of obesity has also continued to rise in those with chronic kidney disease. Epidemiological data suggests those with overweight an…
View article: Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease
Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease Open
View article: Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD
Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD Open
Background and objectives Clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD), including evidence of vascular dysfunction, can begin in childhood. Curcumin is a polyphenol found in turmeric that reduces vascular…
View article: PKD1 Compared With PKD2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies
PKD1 Compared With PKD2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies Open
View article: Fasting and postprandial trimethylamine <i>N</i> ‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet
Fasting and postprandial trimethylamine <i>N</i> ‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet Open
Gut bacteria release trimethylamine (TMA) from dietary substrates. TMA is absorbed and is subsequently oxidized in the liver to produce trimethylamine N-oxide (TMAO). Plasma TMAO levels are positively correlated with risk for type 2 diabet…
View article: Gut Microbiota-Generated Trimethylamine N-Oxide and Cardiometabolic Health in Humans
Gut Microbiota-Generated Trimethylamine N-Oxide and Cardiometabolic Health in Humans Open
There is an association between the human microbiome and disease. Gut microbes metabolize dietary sources to release trimethylamine (TMA). TMA is absorbed and then oxidized by flavin monooxygenase 3 (FMO3) to form trimethylamine N-oxide (T…
View article: Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes
Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes Open
Trimethylamine N-oxide (TMAO) is associated with type 2 diabetes (T2DM) and increased risk of adverse cardiovascular events. Prebiotic supplementation has been purported to reduce TMAO production, but whether prebiotics reduce fasting or p…
View article: Impact of short-term flavanol supplementation on fasting plasma trimethylamine <i>N</i>-oxide concentrations in obese adults
Impact of short-term flavanol supplementation on fasting plasma trimethylamine <i>N</i>-oxide concentrations in obese adults Open
Short-term flavanol supplementation does not reduce levels of proatherogenic TMAO in adults at risk for insulin resistance.
View article: Cardiac Output Dependency on Exercising Muscle Mass During Ergometer Exercise in Healthy Women
Cardiac Output Dependency on Exercising Muscle Mass During Ergometer Exercise in Healthy Women Open